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Published in: Neurosurgical Review 3/2015

01-07-2015 | Review

Analgesic therapy for major spine surgery

Authors: Varun Puvanesarajah, Jason A. Liauw, Sheng-fu Lo, Ioan A. Lina, Timothy F. Witham, Allan Gottschalk

Published in: Neurosurgical Review | Issue 3/2015

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Abstract

Pain following spine surgery is often difficult to control and can persist. Reduction of this pain requires a multidisciplinary approach that depends on contributions of both surgeons and anesthesiologists. The spine surgeon’s role involves limiting manipulation of structures contributing to pain sensation in the spine, which requires an in-depth understanding of the specific anatomic etiologies of pain originating along the spinal axis. Anesthesiologists, on the other hand, must focus on preemptive, multimodal analgesic treatment regimens. In this review, we first discuss anatomic sources of pain within the spine, before delving into a specific literature-supported pain management protocol intended for use with spinal surgery.
Literature
2.
go back to reference Aroni F, Iacovidou N, Dontas I, Pourzitaki C, Xanthos T (2009) Pharmacological aspects and potential new clinical applications of ketamine: Reevaluation of an old drug. J Clin Pharmacol 49(8):957–964. doi:10.1177/0091270009337941 PubMed Aroni F, Iacovidou N, Dontas I, Pourzitaki C, Xanthos T (2009) Pharmacological aspects and potential new clinical applications of ketamine: Reevaluation of an old drug. J Clin Pharmacol 49(8):957–964. doi:10.​1177/​0091270009337941​ PubMed
3.
go back to reference Bach S, Noreng MF, Tjellden NU (1988) Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockade. Pain 33(3):297–301PubMed Bach S, Noreng MF, Tjellden NU (1988) Phantom limb pain in amputees during the first 12 months following limb amputation, after preoperative lumbar epidural blockade. Pain 33(3):297–301PubMed
4.
go back to reference Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH (1990) Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology 73(5):826–830PubMed Bailey PL, Pace NL, Ashburn MA, Moll JW, East KA, Stanley TH (1990) Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. Anesthesiology 73(5):826–830PubMed
6.
go back to reference Benedetti F, Vighetti S, Ricco C, Amanzio M, Bergamasco L, Casadio C, Cianci R, Giobbe R, Oliaro A, Bergamasco B, Maggi G (1998) Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy. J Thorac Cardiovasc Surg 115(4):841–847PubMed Benedetti F, Vighetti S, Ricco C, Amanzio M, Bergamasco L, Casadio C, Cianci R, Giobbe R, Oliaro A, Bergamasco B, Maggi G (1998) Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy. J Thorac Cardiovasc Surg 115(4):841–847PubMed
7.
go back to reference Bessiere B, Laboureyras E, Chateauraynaud J, Laulin JP, Simonnet G (2010) A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. J Pain Off J Am Pain Soc 11(1):13–23. doi:10.1016/j.jpain.2009.05.003 Bessiere B, Laboureyras E, Chateauraynaud J, Laulin JP, Simonnet G (2010) A single nitrous oxide (N2O) exposure leads to persistent alleviation of neuropathic pain in rats. J Pain Off J Am Pain Soc 11(1):13–23. doi:10.​1016/​j.​jpain.​2009.​05.​003
8.
go back to reference Bevan S, Geppetti P (1994) Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci 17(12):509–512PubMed Bevan S, Geppetti P (1994) Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci 17(12):509–512PubMed
9.
go back to reference Blacklock JB, Rea GL, Maxwell RE (1986) Intrathecal morphine during lumbar spine operation for postoperative pain control. Neurosurgery 18(3):341–344PubMed Blacklock JB, Rea GL, Maxwell RE (1986) Intrathecal morphine during lumbar spine operation for postoperative pain control. Neurosurgery 18(3):341–344PubMed
10.
go back to reference Blackman RG, Reynolds J, Shively J (1991) Intrathecal morphine: Dosage and efficacy in younger patients for control of postoperative pain following spinal fusion. Orthopedics 14(5):555–557PubMed Blackman RG, Reynolds J, Shively J (1991) Intrathecal morphine: Dosage and efficacy in younger patients for control of postoperative pain following spinal fusion. Orthopedics 14(5):555–557PubMed
11.
go back to reference Blumenthal S, Min K, Nadig M, Borgeat A (2005) Double epidural catheter with ropivacaine versus intravenous morphine: a comparison for postoperative analgesia after scoliosis correction surgery. Anesthesiology 102(1):175–180PubMed Blumenthal S, Min K, Nadig M, Borgeat A (2005) Double epidural catheter with ropivacaine versus intravenous morphine: a comparison for postoperative analgesia after scoliosis correction surgery. Anesthesiology 102(1):175–180PubMed
12.
go back to reference Boezaart AP, Eksteen JA, Spuy GV, Rossouw P, Knipe M (1999) Intrathecal morphine. Double-blind evaluation of optimal dosage for analgesia after major lumbar spinal surgery. Spine 24(11):1131–1137PubMed Boezaart AP, Eksteen JA, Spuy GV, Rossouw P, Knipe M (1999) Intrathecal morphine. Double-blind evaluation of optimal dosage for analgesia after major lumbar spinal surgery. Spine 24(11):1131–1137PubMed
13.
go back to reference Bonhomme V, Doll A, Dewandre PY, Brichant JF, Ghassempour K, Hans P (2002) Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery. J Neurosurg Anesthesiol 14(1):1–6PubMed Bonhomme V, Doll A, Dewandre PY, Brichant JF, Ghassempour K, Hans P (2002) Epidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery. J Neurosurg Anesthesiol 14(1):1–6PubMed
14.
go back to reference Bourke DL, Spatz E, Motara R, Ordia JI, Reed J, Hlavacek JM (1992) Epidural opioids during laminectomy surgery for postoperative pain. J Clin Anesth 4(4):277–281PubMed Bourke DL, Spatz E, Motara R, Ordia JI, Reed J, Hlavacek JM (1992) Epidural opioids during laminectomy surgery for postoperative pain. J Clin Anesth 4(4):277–281PubMed
15.
go back to reference Burgess GM, Mullaney I, McNeill M, Dunn PM, Rang HP (1989) Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J Neuroscience 9(9):3314–3325 Burgess GM, Mullaney I, McNeill M, Dunn PM, Rang HP (1989) Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J Neuroscience 9(9):3314–3325
18.
go back to reference Cassady JF Jr, Lederhaas G, Cancel DD, Cummings RJ, Loveless EA (2000) A randomized comparison of the effects of continuous thoracic epidural analgesia and intravenous patient-controlled analgesia after posterior spinal fusion in adolescents. Reg Anesthes Pain Med 25(3):246–253 Cassady JF Jr, Lederhaas G, Cancel DD, Cummings RJ, Loveless EA (2000) A randomized comparison of the effects of continuous thoracic epidural analgesia and intravenous patient-controlled analgesia after posterior spinal fusion in adolescents. Reg Anesthes Pain Med 25(3):246–253
19.
go back to reference Caumo W, Schmidt AP, Schneider CN, Bergmann J, Iwamoto CW, Adamatti LC, Bandeira D, Ferreira MB (2002) Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery. Acta Anaesthesiol Scand 46(10):1265–1271PubMed Caumo W, Schmidt AP, Schneider CN, Bergmann J, Iwamoto CW, Adamatti LC, Bandeira D, Ferreira MB (2002) Preoperative predictors of moderate to intense acute postoperative pain in patients undergoing abdominal surgery. Acta Anaesthesiol Scand 46(10):1265–1271PubMed
21.
go back to reference Chen C, Lu Y, Kallakuri S, Patwardhan A, Cavanaugh JM (2006) Distribution of A-delta and C-fiber receptors in the cervical facet joint capsule and their response to stretch. J Bone Joint Surg Am 88(8):1807–1816. doi:10.2106/jbjs.e.00880 PubMed Chen C, Lu Y, Kallakuri S, Patwardhan A, Cavanaugh JM (2006) Distribution of A-delta and C-fiber receptors in the cervical facet joint capsule and their response to stretch. J Bone Joint Surg Am 88(8):1807–1816. doi:10.​2106/​jbjs.​e.​00880 PubMed
22.
go back to reference Coderre TJ, Katz J (1997) Peripheral and central hyperexcitability: Differential signs and symptoms in persistent pain. Behav Brain Sci 20(3):404–419, discussion 435–513PubMed Coderre TJ, Katz J (1997) Peripheral and central hyperexcitability: Differential signs and symptoms in persistent pain. Behav Brain Sci 20(3):404–419, discussion 435–513PubMed
23.
go back to reference Coderre TJ, Katz J, Vaccarino AL, Melzack R (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52(3):259–285PubMed Coderre TJ, Katz J, Vaccarino AL, Melzack R (1993) Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52(3):259–285PubMed
24.
go back to reference Cohen SP, Raja SN (2007) Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology 106(3):591–614PubMed Cohen SP, Raja SN (2007) Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology 106(3):591–614PubMed
25.
go back to reference Cohen BE, Hartman MB, Wade JT, Miller JS, Gilbert R, Chapman TM (1997) Postoperative pain control after lumbar spine fusion. Patient-controlled analgesia versus continuous epidural analgesia. Spine 22(16):1892–1896, discussion 1896–1897PubMed Cohen BE, Hartman MB, Wade JT, Miller JS, Gilbert R, Chapman TM (1997) Postoperative pain control after lumbar spine fusion. Patient-controlled analgesia versus continuous epidural analgesia. Spine 22(16):1892–1896, discussion 1896–1897PubMed
26.
go back to reference Coppes MH, Marani E, Thomeer RT, Groen GJ (1997) Innervation of "painful" lumbar discs. Spine 22(20):2342–2349, discussion 2349–2350PubMed Coppes MH, Marani E, Thomeer RT, Groen GJ (1997) Innervation of "painful" lumbar discs. Spine 22(20):2342–2349, discussion 2349–2350PubMed
27.
go back to reference Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sik A, De Koninck P, De Koninck Y (2003) Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424(6951):938–942. doi:10.1038/nature01868 PubMed Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sik A, De Koninck P, De Koninck Y (2003) Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424(6951):938–942. doi:10.​1038/​nature01868 PubMed
28.
go back to reference Davis JJ, Swenson JD, Hall RH, Dillon JD, Johnson KB, Egan TD, Pace NL, Niu SY (2005) Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients. Anesth Analg 101(2):389–395. doi:10.1213/01.ane.0000156563.25878.19, table of contentsPubMed Davis JJ, Swenson JD, Hall RH, Dillon JD, Johnson KB, Egan TD, Pace NL, Niu SY (2005) Preoperative "fentanyl challenge" as a tool to estimate postoperative opioid dosing in chronic opioid-consuming patients. Anesth Analg 101(2):389–395. doi:10.​1213/​01.​ane.​0000156563.​25878.​19, table of contentsPubMed
30.
go back to reference Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W (2005) Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 14(1):135–143. doi:10.1093/hmg/ddi013 PubMed Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W (2005) Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 14(1):135–143. doi:10.​1093/​hmg/​ddi013 PubMed
31.
go back to reference Dreyfuss P, Halbrook B, Pauza K, Joshi A, McLarty J, Bogduk N (2000) Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine 25(10):1270–1277PubMed Dreyfuss P, Halbrook B, Pauza K, Joshi A, McLarty J, Bogduk N (2000) Efficacy and validity of radiofrequency neurotomy for chronic lumbar zygapophysial joint pain. Spine 25(10):1270–1277PubMed
33.
go back to reference Farr M, Mathews J, Zhu DF, Ambron RT (1999) Inflammation causes a long-term hyperexcitability in the nociceptive sensory neurons of Aplysia. Learn Mem (Cold Spring Harbor, NY) 6(3):331–340 Farr M, Mathews J, Zhu DF, Ambron RT (1999) Inflammation causes a long-term hyperexcitability in the nociceptive sensory neurons of Aplysia. Learn Mem (Cold Spring Harbor, NY) 6(3):331–340
35.
go back to reference Fineberg SJ, Nandyala SV, Kurd MF, Marquez-Lara A, Noureldin M, Sankaranarayanan S, Patel AA, Oglesby M, Singh K (2013) Incidence and risk factors for postoperative ileus following anterior, posterior, and circumferential lumbar fusion. Spine J Off J N Am Spine Soc. doi:10.1016/j.spinee.2013.10.015 Fineberg SJ, Nandyala SV, Kurd MF, Marquez-Lara A, Noureldin M, Sankaranarayanan S, Patel AA, Oglesby M, Singh K (2013) Incidence and risk factors for postoperative ileus following anterior, posterior, and circumferential lumbar fusion. Spine J Off J N Am Spine Soc. doi:10.​1016/​j.​spinee.​2013.​10.​015
37.
go back to reference France JC, Jorgenson SS, Lowe TG, Dwyer AP (1997) The use of intrathecal morphine for analgesia after posterolateral lumbar fusion: a prospective, double-blind, randomized study. Spine 22(19):2272–2277PubMed France JC, Jorgenson SS, Lowe TG, Dwyer AP (1997) The use of intrathecal morphine for analgesia after posterolateral lumbar fusion: a prospective, double-blind, randomized study. Spine 22(19):2272–2277PubMed
38.
go back to reference Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O’Brien J, Jayson MI (1997) Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 350(9072):178–181PubMed Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O’Brien J, Jayson MI (1997) Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 350(9072):178–181PubMed
39.
go back to reference Glassman SD, Rose SM, Dimar JR, Puno RM, Campbell MJ, Johnson JR (1998) The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine 23(7):834–838PubMed Glassman SD, Rose SM, Dimar JR, Puno RM, Campbell MJ, Johnson JR (1998) The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine 23(7):834–838PubMed
40.
go back to reference Gottschalk A, Smith DS (2001) New concepts in acute pain therapy: Preemptive analgesia. Am Fam Physician 63(10):1979–1984PubMed Gottschalk A, Smith DS (2001) New concepts in acute pain therapy: Preemptive analgesia. Am Fam Physician 63(10):1979–1984PubMed
41.
go back to reference Gottschalk A, Smith DS, Jobes DR, Kennedy SK, Lally SE, Noble VE, Grugan KF, Seifert HA, Cheung A, Malkowicz SB, Gutsche BB, Wein AJ (1998) Preemptive epidural analgesia and recovery from radical prostatectomy: a randomized controlled trial. JAMA 279(14):1076–1082PubMed Gottschalk A, Smith DS, Jobes DR, Kennedy SK, Lally SE, Noble VE, Grugan KF, Seifert HA, Cheung A, Malkowicz SB, Gutsche BB, Wein AJ (1998) Preemptive epidural analgesia and recovery from radical prostatectomy: a randomized controlled trial. JAMA 279(14):1076–1082PubMed
42.
go back to reference Gottschalk A, Freitag M, Tank S, Burmeister MA, Kreil S, Kothe R, Hansen-Algenstedt N, Weisner L, Staude HJ, Standl T (2004) Quality of postoperative pain using an intraoperatively placed epidural catheter after major lumbar spinal surgery. Anesthesiology 101(1):175–180PubMed Gottschalk A, Freitag M, Tank S, Burmeister MA, Kreil S, Kothe R, Hansen-Algenstedt N, Weisner L, Staude HJ, Standl T (2004) Quality of postoperative pain using an intraoperatively placed epidural catheter after major lumbar spinal surgery. Anesthesiology 101(1):175–180PubMed
44.
go back to reference Grant AM, Scott NW, O’Dwyer PJ (2004) Five-year follow-up of a randomized trial to assess pain and numbness after laparoscopic or open repair of groin hernia. Bri J Surg 91(12):1570–1574. doi:10.1002/bjs.4799 Grant AM, Scott NW, O’Dwyer PJ (2004) Five-year follow-up of a randomized trial to assess pain and numbness after laparoscopic or open repair of groin hernia. Bri J Surg 91(12):1570–1574. doi:10.​1002/​bjs.​4799
45.
46.
go back to reference Guignard B, Bossard AE, Coste C, Sessler DI, Lebrault C, Alfonsi P, Fletcher D, Chauvin M (2000) Acute opioid tolerance: Intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 93(2):409–417PubMed Guignard B, Bossard AE, Coste C, Sessler DI, Lebrault C, Alfonsi P, Fletcher D, Chauvin M (2000) Acute opioid tolerance: Intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology 93(2):409–417PubMed
47.
go back to reference HA W (1991) The failed back surgery syndrome: etiology and therapy. 2nd edn HA W (1991) The failed back surgery syndrome: etiology and therapy. 2nd edn
48.
go back to reference Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG (2003) Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neuroscience 23(26):8881–8892 Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG (2003) Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neuroscience 23(26):8881–8892
49.
go back to reference Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG (2004) Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neuroscience 24(20):4832–4839. doi:10.1523/jneurosci. 0300-04.2004 Hains BC, Saab CY, Klein JP, Craner MJ, Waxman SG (2004) Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neuroscience 24(20):4832–4839. doi:10.​1523/​jneurosci.​ 0300-04.​2004
50.
go back to reference Hakim AJ, Cherkas L, El Zayat S, MacGregor AJ, Spector TD (2002) The genetic contribution to carpal tunnel syndrome in women: a twin study. Arthritis Rheum 47(3):275–279. doi:10.1002/art.10395 PubMed Hakim AJ, Cherkas L, El Zayat S, MacGregor AJ, Spector TD (2002) The genetic contribution to carpal tunnel syndrome in women: a twin study. Arthritis Rheum 47(3):275–279. doi:10.​1002/​art.​10395 PubMed
51.
go back to reference Hanley MA, Jensen MP, Ehde DM, Hoffman AJ, Patterson DR, Robinson LR (2004) Psychosocial predictors of long-term adjustment to lower-limb amputation and phantom limb pain. Disabil Rehabil 26(14–15):882–893PubMed Hanley MA, Jensen MP, Ehde DM, Hoffman AJ, Patterson DR, Robinson LR (2004) Psychosocial predictors of long-term adjustment to lower-limb amputation and phantom limb pain. Disabil Rehabil 26(14–15):882–893PubMed
52.
go back to reference Hart LG, Deyo RA, Cherkin DC (1995) Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine 20(1):11–19PubMed Hart LG, Deyo RA, Cherkin DC (1995) Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine 20(1):11–19PubMed
53.
go back to reference Hartvigsen J, Christensen K, Frederiksen H, Petersen HC (2004) Genetic and environmental contributions to back pain in old age: a study of 2,108 danish twins aged 70 and older. Spine 29(8):897–901, discussion 902PubMed Hartvigsen J, Christensen K, Frederiksen H, Petersen HC (2004) Genetic and environmental contributions to back pain in old age: a study of 2,108 danish twins aged 70 and older. Spine 29(8):897–901, discussion 902PubMed
54.
go back to reference Hayes C, Armstrong-Brown A, Burstal R (2004) Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care 32(3):330–338PubMed Hayes C, Armstrong-Brown A, Burstal R (2004) Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care 32(3):330–338PubMed
55.
go back to reference Herminghaus A, Wachowiak M, Wilhelm W, Gottschalk A, Eggert K, Gottschalk A (2011) Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage. Anaesthesist 60(2):152–160. doi:10.1007/s00101-010-1829-0 PubMed Herminghaus A, Wachowiak M, Wilhelm W, Gottschalk A, Eggert K, Gottschalk A (2011) Intravenous administration of lidocaine for perioperative analgesia. Review and recommendations for practical usage. Anaesthesist 60(2):152–160. doi:10.​1007/​s00101-010-1829-0 PubMed
56.
go back to reference Hong S, Wiley JW (2005) Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem 280(1):618–627. doi:10.1074/jbc.M408500200 PubMed Hong S, Wiley JW (2005) Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem 280(1):618–627. doi:10.​1074/​jbc.​M408500200 PubMed
57.
go back to reference Hudson LJ, Bevan S, Wotherspoon G, Gentry C, Fox A, Winter J (2001) VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur J Neurosci 13(11):2105–2114PubMed Hudson LJ, Bevan S, Wotherspoon G, Gentry C, Fox A, Winter J (2001) VR1 protein expression increases in undamaged DRG neurons after partial nerve injury. Eur J Neurosci 13(11):2105–2114PubMed
58.
go back to reference Ibrahim AW, Farag H, Naguib M (1986) Epidural morphine for pain relief after lumbar laminectomy. Spine 11(10):1024–1026PubMed Ibrahim AW, Farag H, Naguib M (1986) Epidural morphine for pain relief after lumbar laminectomy. Spine 11(10):1024–1026PubMed
59.
go back to reference Igarashi A, Kikuchi S, Konno S (2007) Correlation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disorders. J Orthop Sci 12(2):154–160. doi:10.1007/s00776-006-1105-y PubMed Igarashi A, Kikuchi S, Konno S (2007) Correlation between inflammatory cytokines released from the lumbar facet joint tissue and symptoms in degenerative lumbar spinal disorders. J Orthop Sci 12(2):154–160. doi:10.​1007/​s00776-006-1105-y PubMed
60.
go back to reference Iohom G, Abdalla H, O’Brien J, Szarvas S, Larney V, Buckley E, Butler M, Shorten GD (2006) The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery. Anesth Analg 103(4):995–1000. doi:10.1213/01.ane.0000240415.49180.4a PubMed Iohom G, Abdalla H, O’Brien J, Szarvas S, Larney V, Buckley E, Butler M, Shorten GD (2006) The associations between severity of early postoperative pain, chronic postsurgical pain and plasma concentration of stable nitric oxide products after breast surgery. Anesth Analg 103(4):995–1000. doi:10.​1213/​01.​ane.​0000240415.​49180.​4a PubMed
61.
go back to reference Joshi GP, McCarroll SM, O’Rourke K (1995) Postoperative analgesia after lumbar laminectomy: Epidural fentanyl infusion versus patient-controlled intravenous morphine. Anesth Analg 80(3):511–514PubMed Joshi GP, McCarroll SM, O’Rourke K (1995) Postoperative analgesia after lumbar laminectomy: Epidural fentanyl infusion versus patient-controlled intravenous morphine. Anesth Analg 80(3):511–514PubMed
62.
go back to reference Jung BF, Ahrendt GM, Oaklander AL, Dworkin RH (2003) Neuropathic pain following breast cancer surgery: Proposed classification and research update. Pain 104(1–2):1–13PubMed Jung BF, Ahrendt GM, Oaklander AL, Dworkin RH (2003) Neuropathic pain following breast cancer surgery: Proposed classification and research update. Pain 104(1–2):1–13PubMed
63.
go back to reference Kallakuri S, Singh A, Chen C, Cavanaugh JM (2004) Demonstration of substance P, calcitonin gene-related peptide, and protein gene product 9.5 containing nerve fibers in human cervical facet joint capsules. Spine 29(11):1182–1186PubMed Kallakuri S, Singh A, Chen C, Cavanaugh JM (2004) Demonstration of substance P, calcitonin gene-related peptide, and protein gene product 9.5 containing nerve fibers in human cervical facet joint capsules. Spine 29(11):1182–1186PubMed
65.
go back to reference Katz J, Jackson M, Kavanagh BP, Sandler AN (1996) Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain 12(1):50–55PubMed Katz J, Jackson M, Kavanagh BP, Sandler AN (1996) Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin J Pain 12(1):50–55PubMed
66.
go back to reference Katz J, Schmid R, Snijdelaar DG, Coderre TJ, McCartney CJ, Wowk A (2004) Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use. Pain 110(3):707–718. doi:10.1016/j.pain.2004.05.011 PubMed Katz J, Schmid R, Snijdelaar DG, Coderre TJ, McCartney CJ, Wowk A (2004) Pre-emptive analgesia using intravenous fentanyl plus low-dose ketamine for radical prostatectomy under general anesthesia does not produce short-term or long-term reductions in pain or analgesic use. Pain 110(3):707–718. doi:10.​1016/​j.​pain.​2004.​05.​011 PubMed
69.
go back to reference Kawaguchi Y, Matsui H, Tsuji H (1994) Back muscle injury after posterior lumbar spine surgery. Part 2: histologic and histochemical analyses in humans. Spine 19(22):2598–2602PubMed Kawaguchi Y, Matsui H, Tsuji H (1994) Back muscle injury after posterior lumbar spine surgery. Part 2: histologic and histochemical analyses in humans. Spine 19(22):2598–2602PubMed
70.
go back to reference Kawaguchi Y, Matsui H, Tsuji H (1996) Back muscle injury after posterior lumbar spine surgery. A histologic and enzymatic analysis. Spine 21(8):941–944PubMed Kawaguchi Y, Matsui H, Tsuji H (1996) Back muscle injury after posterior lumbar spine surgery. A histologic and enzymatic analysis. Spine 21(8):941–944PubMed
71.
go back to reference Kawakami M, Weinstein JN, Spratt KF, Chatani K, Traub RJ, Meller ST, Gebhart GF (1994) Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat. Spine 19(16):1780–1794PubMed Kawakami M, Weinstein JN, Spratt KF, Chatani K, Traub RJ, Meller ST, Gebhart GF (1994) Experimental lumbar radiculopathy. Immunohistochemical and quantitative demonstrations of pain induced by lumbar nerve root irritation of the rat. Spine 19(16):1780–1794PubMed
73.
74.
go back to reference Krishtal OA, Pidoplichko VI (1980) A receptor for protons in the nerve cell membrane. Neuroscience 5(12):2325–2327PubMed Krishtal OA, Pidoplichko VI (1980) A receptor for protons in the nerve cell membrane. Neuroscience 5(12):2325–2327PubMed
75.
go back to reference Kundra P, Gurnani A, Bhattacharya A (1997) Preemptive epidural morphine for postoperative pain relief after lumbar laminectomy. Anesth Analg 85(1):135–138PubMed Kundra P, Gurnani A, Bhattacharya A (1997) Preemptive epidural morphine for postoperative pain relief after lumbar laminectomy. Anesth Analg 85(1):135–138PubMed
76.
go back to reference Kuslich SD, Ulstrom CL, Michael CJ (1991) The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Orthop Clin N Am 22(2):181–187 Kuslich SD, Ulstrom CL, Michael CJ (1991) The tissue origin of low back pain and sciatica: a report of pain response to tissue stimulation during operations on the lumbar spine using local anesthesia. Orthop Clin N Am 22(2):181–187
77.
go back to reference Lai J, Hunter JC, Porreca F (2003) The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 13(3):291–297PubMed Lai J, Hunter JC, Porreca F (2003) The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 13(3):291–297PubMed
78.
go back to reference Lambert A, Dashfield A, Cosgrove C, Wilkins D, Walker A, Ashley S (2001) Randomized prospective study comparing preoperative epidural and intraoperative perineural analgesia for the prevention of postoperative stump and phantom limb pain following major amputation. Reg Anesth Pain Med 26(4):316–321 Lambert A, Dashfield A, Cosgrove C, Wilkins D, Walker A, Ashley S (2001) Randomized prospective study comparing preoperative epidural and intraoperative perineural analgesia for the prevention of postoperative stump and phantom limb pain following major amputation. Reg Anesth Pain Med 26(4):316–321
79.
go back to reference Laulin JP, Maurette P, Corcuff JB, Rivat C, Chauvin M, Simonnet G (2002) The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg 94(5):1263–1269, table of contentsPubMed Laulin JP, Maurette P, Corcuff JB, Rivat C, Chauvin M, Simonnet G (2002) The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg 94(5):1263–1269, table of contentsPubMed
81.
go back to reference Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L (2011) A comprehensive review of opioid-induced hyperalgesia. Pain Phys 14(2):145–161 Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L (2011) A comprehensive review of opioid-induced hyperalgesia. Pain Phys 14(2):145–161
82.
go back to reference Lehmann TR, LaRocca HS (1981) Repeat lumbar surgery. A review of patients with failure from previous lumbar surgery treated by spinal canal exploration and lumbar spinal fusion. Spine 6(6):615–619PubMed Lehmann TR, LaRocca HS (1981) Repeat lumbar surgery. A review of patients with failure from previous lumbar surgery treated by spinal canal exploration and lumbar spinal fusion. Spine 6(6):615–619PubMed
84.
go back to reference Liu HT, Hollmann MW, Liu WH, Hoenemann CW, Durieux ME (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth Analg 92(5):1173–1181PubMed Liu HT, Hollmann MW, Liu WH, Hoenemann CW, Durieux ME (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth Analg 92(5):1173–1181PubMed
85.
go back to reference Loftus RW, Yeager MP, Clark JA, Brown JR, Abdu WA, Sengupta DK, Beach ML (2010) Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. Anesthesiology 113(3):639–646. doi:10.1097/ALN.0b013e3181e90914 PubMed Loftus RW, Yeager MP, Clark JA, Brown JR, Abdu WA, Sengupta DK, Beach ML (2010) Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic back pain undergoing back surgery. Anesthesiology 113(3):639–646. doi:10.​1097/​ALN.​0b013e3181e90914​ PubMed
86.
go back to reference Loney PL, Stratford PW (1999) The prevalence of low back pain in adults: a methodological review of the literature. Phys Ther 79(4):384–396PubMed Loney PL, Stratford PW (1999) The prevalence of low back pain in adults: a methodological review of the literature. Phys Ther 79(4):384–396PubMed
87.
go back to reference Lotz JC, Ulrich JA (2006) Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: Review of animal model data. J Bone Joint Surg Am 88(Suppl 2):76–82. doi:10.2106/jbjs.e.01448 PubMed Lotz JC, Ulrich JA (2006) Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: Review of animal model data. J Bone Joint Surg Am 88(Suppl 2):76–82. doi:10.​2106/​jbjs.​e.​01448 PubMed
88.
go back to reference Lowry KJ, Tobias J, Kittle D, Burd T, Gaines RW (2001) Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Spine 26(11):1290–1293PubMed Lowry KJ, Tobias J, Kittle D, Burd T, Gaines RW (2001) Postoperative pain control using epidural catheters after anterior spinal fusion for adolescent scoliosis. Spine 26(11):1290–1293PubMed
89.
go back to reference Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM (2005) Neural response of cervical facet joint capsule to stretch: a study of whiplash pain mechanism. Stapp Car Crash J 49:49–65PubMed Lu Y, Chen C, Kallakuri S, Patwardhan A, Cavanaugh JM (2005) Neural response of cervical facet joint capsule to stretch: a study of whiplash pain mechanism. Stapp Car Crash J 49:49–65PubMed
90.
go back to reference Luginbuhl M, Gerber A, Schnider TW, Petersen-Felix S, Arendt-Nielsen L, Curatolo M (2003) Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans. Anesth Analg 96(3):726–732, table of contentsPubMed Luginbuhl M, Gerber A, Schnider TW, Petersen-Felix S, Arendt-Nielsen L, Curatolo M (2003) Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans. Anesth Analg 96(3):726–732, table of contentsPubMed
91.
go back to reference Mach DB, Rogers SD, Sabino MC, Luger NM, Schwei MJ, Pomonis JD, Keyser CP, Clohisy DR, Adams DJ, O’Leary P, Mantyh PW (2002) Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur. Neuroscience 113(1):155–166PubMed Mach DB, Rogers SD, Sabino MC, Luger NM, Schwei MJ, Pomonis JD, Keyser CP, Clohisy DR, Adams DJ, O’Leary P, Mantyh PW (2002) Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur. Neuroscience 113(1):155–166PubMed
92.
94.
go back to reference McCarthy GC, Megalla SA, Habib AS (2010) Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. Drugs 70(9):1149–1163. doi:10.2165/10898560-000000000-00000 PubMed McCarthy GC, Megalla SA, Habib AS (2010) Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery: a systematic review of randomized controlled trials. Drugs 70(9):1149–1163. doi:10.​2165/​10898560-000000000-00000 PubMed
96.
go back to reference Mense S (2003) The pathogenesis of muscle pain. Curr Pain Headache Rep 7(6):419–425PubMed Mense S (2003) The pathogenesis of muscle pain. Curr Pain Headache Rep 7(6):419–425PubMed
98.
go back to reference Mercadante S (1997) Malignant bone pain: Pathophysiology and treatment. Pain 69(1–2):1–18PubMed Mercadante S (1997) Malignant bone pain: Pathophysiology and treatment. Pain 69(1–2):1–18PubMed
99.
go back to reference Meyer RA DP (1997) Physiology of pain. In: Richard B, North RML (eds) Neurosurgical management of pain. Springer, New York Meyer RA DP (1997) Physiology of pain. In: Richard B, North RML (eds) Neurosurgical management of pain. Springer, New York
100.
go back to reference Mikkelsen T, Werner MU, Lassen B, Kehlet H (2004) Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy. Anesth Analg 99(1):146–151PubMed Mikkelsen T, Werner MU, Lassen B, Kehlet H (2004) Pain and sensory dysfunction 6 to 12 months after inguinal herniotomy. Anesth Analg 99(1):146–151PubMed
102.
go back to reference Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, Grisel JE, Fillingim RB (2003) The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 100(8):4867–4872. doi:10.1073/pnas.0730053100 PubMedCentralPubMed Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, Grisel JE, Fillingim RB (2003) The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 100(8):4867–4872. doi:10.​1073/​pnas.​0730053100 PubMedCentralPubMed
103.
go back to reference Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, Woolf CJ (2002) Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neuroscience 22(15):6724–6731 Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H, Woolf CJ (2002) Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neuroscience 22(15):6724–6731
104.
go back to reference Nath S, Nath CA, Pettersson K (2008) Percutaneous lumbar zygapophysial (Facet) joint neurotomy using radiofrequency current, in the management of chronic low back pain: a randomized double-blind trial. Spine 33(12):1291–1297. doi:10.1097/BRS.0b013e31817329f0, discussion 1298PubMed Nath S, Nath CA, Pettersson K (2008) Percutaneous lumbar zygapophysial (Facet) joint neurotomy using radiofrequency current, in the management of chronic low back pain: a randomized double-blind trial. Spine 33(12):1291–1297. doi:10.​1097/​BRS.​0b013e31817329f0​, discussion 1298PubMed
105.
go back to reference Neidhart P, Burgener MC, Schwieger I, Suter PM (1989) Chest wall rigidity during fentanyl- and midazolam-fentanyl induction: Ventilatory and haemodynamic effects. Acta Anaesthesiol Scand 33(1):1–5PubMed Neidhart P, Burgener MC, Schwieger I, Suter PM (1989) Chest wall rigidity during fentanyl- and midazolam-fentanyl induction: Ventilatory and haemodynamic effects. Acta Anaesthesiol Scand 33(1):1–5PubMed
107.
go back to reference North RB, Campbell JN, James CS, Conover-Walker MK, Wang H, Piantadosi S, Rybock JD, Long DM (1991) Failed back surgery syndrome: 5-year follow-up in 102 patients undergoing repeated operation. Neurosurgery 28(5):685–690, discussion 690–681PubMed North RB, Campbell JN, James CS, Conover-Walker MK, Wang H, Piantadosi S, Rybock JD, Long DM (1991) Failed back surgery syndrome: 5-year follow-up in 102 patients undergoing repeated operation. Neurosurgery 28(5):685–690, discussion 690–681PubMed
108.
go back to reference Obata H, Saito S, Fujita N, Fuse Y, Ishizaki K, Goto F (1999) Epidural block with mepivacaine before surgery reduces long-term post-thoracotomy pain. Can J Anaesth 46(12):1127–1132. doi:10.1007/bf03015520 PubMed Obata H, Saito S, Fujita N, Fuse Y, Ishizaki K, Goto F (1999) Epidural block with mepivacaine before surgery reduces long-term post-thoracotomy pain. Can J Anaesth 46(12):1127–1132. doi:10.​1007/​bf03015520 PubMed
109.
go back to reference Ochroch EA, Gottschalk A, Augostides J, Carson KA, Kent L, Malayaman N, Kaiser LR, Aukburg SJ (2002) Long-term pain and activity during recovery from major thoracotomy using thoracic epidural analgesia. Anesthesiology 97(5):1234–1244PubMed Ochroch EA, Gottschalk A, Augostides J, Carson KA, Kent L, Malayaman N, Kaiser LR, Aukburg SJ (2002) Long-term pain and activity during recovery from major thoracotomy using thoracic epidural analgesia. Anesthesiology 97(5):1234–1244PubMed
110.
go back to reference Olmarker K, Blomquist J, Stromberg J, Nannmark U, Thomsen P, Rydevik B (1995) Inflammatogenic properties of nucleus pulposus. Spine 20(6):665–669PubMed Olmarker K, Blomquist J, Stromberg J, Nannmark U, Thomsen P, Rydevik B (1995) Inflammatogenic properties of nucleus pulposus. Spine 20(6):665–669PubMed
113.
go back to reference Palmgren T, Gronblad M, Virri J, Seitsalo S, Ruuskanen M, Karaharju E (1996) Immunohistochemical demonstration of sensory and autonomic nerve terminals in herniated lumbar disc tissue. Spine 21(11):1301–1306PubMed Palmgren T, Gronblad M, Virri J, Seitsalo S, Ruuskanen M, Karaharju E (1996) Immunohistochemical demonstration of sensory and autonomic nerve terminals in herniated lumbar disc tissue. Spine 21(11):1301–1306PubMed
114.
go back to reference Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, Singh U, Singh PK (2005) Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 17(2):65–68PubMed Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, Singh U, Singh PK (2005) Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol 17(2):65–68PubMed
116.
go back to reference Ray CD, Bagley R (1983) Indwelling epidural morphine for control of post-lumbar spinal surgery pain. Neurosurgery 13(4):388–393PubMed Ray CD, Bagley R (1983) Indwelling epidural morphine for control of post-lumbar spinal surgery pain. Neurosurgery 13(4):388–393PubMed
117.
go back to reference Rechtine GR, Reinert CM, Bohlman HH (1984) The use of epidural morphine to decrease postoperative pain in patients undergoing lumbar laminectomy. J Bone Joint Surg Am 66(1):113–116PubMed Rechtine GR, Reinert CM, Bohlman HH (1984) The use of epidural morphine to decrease postoperative pain in patients undergoing lumbar laminectomy. J Bone Joint Surg Am 66(1):113–116PubMed
118.
119.
go back to reference Revel ME, Listrat VM, Chevalier XJ, Dougados M, N’Guyen MP, Vallee C, Wybier M, Gires F, Amor B (1992) Facet joint block for low back pain: Identifying predictors of a good response. Arch Phys Med Rehabil 73(9):824–828PubMed Revel ME, Listrat VM, Chevalier XJ, Dougados M, N’Guyen MP, Vallee C, Wybier M, Gires F, Amor B (1992) Facet joint block for low back pain: Identifying predictors of a good response. Arch Phys Med Rehabil 73(9):824–828PubMed
120.
go back to reference Ross D, Barbaro NM, Drasner K (1991) Intrathecal morphine for postoperative analgesia in children after selective dorsal rhizotomy. Neurosurgery 29(6):950–951PubMed Ross D, Barbaro NM, Drasner K (1991) Intrathecal morphine for postoperative analgesia in children after selective dorsal rhizotomy. Neurosurgery 29(6):950–951PubMed
122.
go back to reference Rubert CHR, Malawer M (2000) Orthopedic management of skeletal metastases. In: Body J-J (ed) Tumor bone diseases and osteoporosis in cancer patients: Pathophysiology, diagnosis and therapy. Marcel Dekker, New York Rubert CHR, Malawer M (2000) Orthopedic management of skeletal metastases. In: Body J-J (ed) Tumor bone diseases and osteoporosis in cancer patients: Pathophysiology, diagnosis and therapy. Marcel Dekker, New York
123.
go back to reference Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410(6827):471–475. doi:10.1038/35068566 PubMed Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410(6827):471–475. doi:10.​1038/​35068566 PubMed
124.
go back to reference Schaible HG, Schmidt RF (1985) Effects of an experimental arthritis on the sensory properties of fine articular afferent units. J Neurophysiol 54(5):1109–1122PubMed Schaible HG, Schmidt RF (1985) Effects of an experimental arthritis on the sensory properties of fine articular afferent units. J Neurophysiol 54(5):1109–1122PubMed
125.
go back to reference Schley M, Topfner S, Wiech K, Schaller HE, Konrad CJ, Schmelz M, Birbaumer N (2007) Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees. Eur J Pain (London, England) 11(3):299–308. doi:10.1016/j.ejpain.2006.03.003 Schley M, Topfner S, Wiech K, Schaller HE, Konrad CJ, Schmelz M, Birbaumer N (2007) Continuous brachial plexus blockade in combination with the NMDA receptor antagonist memantine prevents phantom pain in acute traumatic upper limb amputees. Eur J Pain (London, England) 11(3):299–308. doi:10.​1016/​j.​ejpain.​2006.​03.​003
126.
go back to reference Schmidek HH, Cutler SG (1983) Epidural morphine for control of pain after spinal surgery: a preliminary report. Neurosurgery 13(1):37–39PubMed Schmidek HH, Cutler SG (1983) Epidural morphine for control of pain after spinal surgery: a preliminary report. Neurosurgery 13(1):37–39PubMed
127.
go back to reference Senturk M, Ozcan PE, Talu GK, Kiyan E, Camci E, Ozyalcin S, Dilege S, Pembeci K (2002) The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg 94(1):11–15, table of contentsPubMed Senturk M, Ozcan PE, Talu GK, Kiyan E, Camci E, Ozyalcin S, Dilege S, Pembeci K (2002) The effects of three different analgesia techniques on long-term postthoracotomy pain. Anesth Analg 94(1):11–15, table of contentsPubMed
128.
go back to reference Sepehrnia A, van Ouwerkerk WJ (1996) Analgesic effect of epidural morphine in lumbar disc surgery. Neurosurg Rev 19(4):227–230PubMed Sepehrnia A, van Ouwerkerk WJ (1996) Analgesic effect of epidural morphine in lumbar disc surgery. Neurosurg Rev 19(4):227–230PubMed
129.
go back to reference Shafer SL, Varvel JR, Aziz N, Scott JC (1990) Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology 73(6):1091–1102PubMed Shafer SL, Varvel JR, Aziz N, Scott JC (1990) Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology 73(6):1091–1102PubMed
130.
go back to reference Shaw BA, Watson TC, Merzel DI, Gerardi JA, Birek A (1996) The safety of continuous epidural infusion for postoperative analgesia in pediatric spine surgery. J Pediatr Orthop 16(3):374–377PubMed Shaw BA, Watson TC, Merzel DI, Gerardi JA, Birek A (1996) The safety of continuous epidural infusion for postoperative analgesia in pediatric spine surgery. J Pediatr Orthop 16(3):374–377PubMed
131.
go back to reference Silver IA, Murrills RJ, Etherington DJ (1988) Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175(2):266–276PubMed Silver IA, Murrills RJ, Etherington DJ (1988) Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp Cell Res 175(2):266–276PubMed
132.
go back to reference Smith NT, Benthuysen JL, Bickford RG, Sanford TJ, Blasco T, Duke PC, Head N, Dec-Silver H (1989) Seizures during opioid anesthetic induction—are they opioid-induced rigidity? Anesthesiology 71(6):852–862PubMed Smith NT, Benthuysen JL, Bickford RG, Sanford TJ, Blasco T, Duke PC, Head N, Dec-Silver H (1989) Seizures during opioid anesthetic induction—are they opioid-induced rigidity? Anesthesiology 71(6):852–862PubMed
134.
go back to reference Southall MD, Michael RL, Vasko MR (1998) Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices. Pain 78(1):39–48PubMed Southall MD, Michael RL, Vasko MR (1998) Intrathecal NSAIDS attenuate inflammation-induced neuropeptide release from rat spinal cord slices. Pain 78(1):39–48PubMed
135.
go back to reference Sucato DJ, Lovejoy JF, Agrawal S, Elerson E, Nelson T, McClung A (2008) Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. Spine 33(10):1119–1124. doi:10.1097/BRS.0b013e31816f6a2a PubMed Sucato DJ, Lovejoy JF, Agrawal S, Elerson E, Nelson T, McClung A (2008) Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. Spine 33(10):1119–1124. doi:10.​1097/​BRS.​0b013e31816f6a2a​ PubMed
137.
go back to reference Tasmuth T, Estlanderb AM, Kalso E (1996) Effect of present pain and mood on the memory of past postoperative pain in women treated surgically for breast cancer. Pain 68(2–3):343–347PubMed Tasmuth T, Estlanderb AM, Kalso E (1996) Effect of present pain and mood on the memory of past postoperative pain in women treated surgically for breast cancer. Pain 68(2–3):343–347PubMed
139.
go back to reference Turan A, Karamanlioglu B, Memis D, Hamamcioglu MK, Tukenmez B, Pamukcu Z, Kurt I (2004) Analgesic effects of gabapentin after spinal surgery. Anesthesiology 100(4):935–938PubMed Turan A, Karamanlioglu B, Memis D, Hamamcioglu MK, Tukenmez B, Pamukcu Z, Kurt I (2004) Analgesic effects of gabapentin after spinal surgery. Anesthesiology 100(4):935–938PubMed
140.
go back to reference Turk DC FH (1999) Psychosocial factors in pain: Critical perspectives. In: Gatchel RJ TD (ed) Chronic pain: a biobehavioral perspective. Guilford Press, New York, pp 18–34 Turk DC FH (1999) Psychosocial factors in pain: Critical perspectives. In: Gatchel RJ TD (ed) Chronic pain: a biobehavioral perspective. Guilford Press, New York, pp 18–34
141.
go back to reference Turner A, Lee J, Mitchell R, Berman J, Edge G, Fennelly M (2000) The efficacy of surgically placed epidural catheters for analgesia after posterior spinal surgery. Anaesthesia 55(4):370–373PubMed Turner A, Lee J, Mitchell R, Berman J, Edge G, Fennelly M (2000) The efficacy of surgically placed epidural catheters for analgesia after posterior spinal surgery. Anaesthesia 55(4):370–373PubMed
142.
go back to reference Tverskoy M, Oz Y, Isakson A, Finger J, Bradley EL Jr, Kissin I (1994) Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. Anesth Analg 78(2):205–209PubMed Tverskoy M, Oz Y, Isakson A, Finger J, Bradley EL Jr, Kissin I (1994) Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. Anesth Analg 78(2):205–209PubMed
143.
go back to reference Urban JP, Smith S, Fairbank JC (2004) Nutrition of the intervertebral disc. Spine 29(23):2700–2709PubMed Urban JP, Smith S, Fairbank JC (2004) Nutrition of the intervertebral disc. Spine 29(23):2700–2709PubMed
146.
go back to reference Waldmann R, Champigny G, Lingueglia E, De Weille JR, Heurteaux C, Lazdunski M (1999) H(+)-gated cation channels. Ann N Y Acad Sci 868:67–76PubMed Waldmann R, Champigny G, Lingueglia E, De Weille JR, Heurteaux C, Lazdunski M (1999) H(+)-gated cation channels. Ann N Y Acad Sci 868:67–76PubMed
147.
go back to reference White PF (2005) The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 101(5 Suppl):S5–S22PubMed White PF (2005) The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 101(5 Suppl):S5–S22PubMed
148.
go back to reference Wilder-Smith CH, Knopfli R, Wilder-Smith OH (1997) Perioperative magnesium infusion and postoperative pain. Acta Anaesthesiol Scand 41(8):1023–1027PubMed Wilder-Smith CH, Knopfli R, Wilder-Smith OH (1997) Perioperative magnesium infusion and postoperative pain. Acta Anaesthesiol Scand 41(8):1023–1027PubMed
149.
go back to reference Wilson JA, Nimmo AF, Fleetwood-Walker SM, Colvin LA (2008) A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation. Pain 135(1–2):108–118. doi:10.1016/j.pain.2007.05.011 PubMed Wilson JA, Nimmo AF, Fleetwood-Walker SM, Colvin LA (2008) A randomised double blind trial of the effect of pre-emptive epidural ketamine on persistent pain after lower limb amputation. Pain 135(1–2):108–118. doi:10.​1016/​j.​pain.​2007.​05.​011 PubMed
150.
go back to reference Yamakura T, Harris RA (2000) Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 93(4):1095–1101PubMed Yamakura T, Harris RA (2000) Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 93(4):1095–1101PubMed
151.
go back to reference Yamamoto T, Sakashita Y (1998) COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA. Neuroreport 9(17):3869–3873PubMed Yamamoto T, Sakashita Y (1998) COX-2 inhibitor prevents the development of hyperalgesia induced by intrathecal NMDA or AMPA. Neuroreport 9(17):3869–3873PubMed
152.
go back to reference Yamashita T, Cavanaugh JM, el-Bohy AA, Getchell TV, King AI (1990) Mechanosensitive afferent units in the lumbar facet joint. J Bone Joint Surg Am 72(6):865–870PubMed Yamashita T, Cavanaugh JM, el-Bohy AA, Getchell TV, King AI (1990) Mechanosensitive afferent units in the lumbar facet joint. J Bone Joint Surg Am 72(6):865–870PubMed
153.
go back to reference Yang KH, King AI (1984) Mechanism of facet load transmission as a hypothesis for low-back pain. Spine 9(6):557–565PubMed Yang KH, King AI (1984) Mechanism of facet load transmission as a hypothesis for low-back pain. Spine 9(6):557–565PubMed
154.
go back to reference Yukawa Y, Kato F, Ito K, Terashima T, Horie Y (2005) A prospective randomized study of preemptive analgesia for postoperative pain in the patients undergoing posterior lumbar interbody fusion: continuous subcutaneous morphine, continuous epidural morphine, and diclofenac sodium. Spine 30(21):2357–2361PubMed Yukawa Y, Kato F, Ito K, Terashima T, Horie Y (2005) A prospective randomized study of preemptive analgesia for postoperative pain in the patients undergoing posterior lumbar interbody fusion: continuous subcutaneous morphine, continuous epidural morphine, and diclofenac sodium. Spine 30(21):2357–2361PubMed
155.
go back to reference Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D (2003) COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (New York, NY) 299(5610):1240–1243. doi:10.1126/science.1078546 Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D (2003) COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor. Science (New York, NY) 299(5610):1240–1243. doi:10.​1126/​science.​1078546
Metadata
Title
Analgesic therapy for major spine surgery
Authors
Varun Puvanesarajah
Jason A. Liauw
Sheng-fu Lo
Ioan A. Lina
Timothy F. Witham
Allan Gottschalk
Publication date
01-07-2015
Publisher
Springer Berlin Heidelberg
Published in
Neurosurgical Review / Issue 3/2015
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-015-0605-7

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