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Current Cardiology Reports
Published in: Current Cardiology Reports 1/2022

01-01-2022 | Anakinra | New Therapies for Cardiovascular Disease (AA Bavry and MR Massoomi, Section Editors)

Rilonacept (Interleukin-1 Inhibition) for the Treatment of Pericarditis

Authors: Tom Kai Ming Wang, Allan L. Klein

Published in: Current Cardiology Reports | Issue 1/2022

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Abstract

Purpose of Review

We reviewed the contemporary literature and clinical trials to discuss the applications of the interleukin-1 (IL-1) inhibitor rilonacept to treat pericarditis, with regards to pathophysiology, pharmacology, efficacy, and safety.

Recent Findings

Rilonacept is an emerging novel agent for treating recurrent pericarditis, with phase II and III clinical trials recently published. Rilonacept rapidly resolved pericarditis pain and inflammation, markedly reduced recurrent pericarditis episodes, and had few adverse events indicating a high safety profile.

Summary

Recurrent pericarditis is associated with significant morbidity and unmet need for novel therapies. Inflammasomes and the IL-1 pathways were found to be critical in its pathophysiology, leading to IL-1 inhibitors being developed. The high efficacy and safety of rilonacept for recurrent pericarditis means it could potentially be considered as a second-line therapy ahead of or as an alternative to corticosteroids, and highlight the great promise of targeted immunomodulatory therapy in this field.
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Metadata
Title
Rilonacept (Interleukin-1 Inhibition) for the Treatment of Pericarditis
Authors
Tom Kai Ming Wang
Allan L. Klein
Publication date
01-01-2022
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2022
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-021-01621-0

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