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BMC Cancer
Published in: BMC Cancer 1/2006

Open Access 01-12-2006 | Case report

An unusual cause of alveolar hemorrhage post hematopoietic stem cell transplantation: A case report

Authors: Sachin Gupta, Amit Jain, Tina V Fanning, Daniel R Couriel, Carlos A Jimenez, Georgie A Eapen

Published in: BMC Cancer | Issue 1/2006

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Abstract

Background

Hematopoietic stem cell transplantation is being increasingly used in cancer therapy. Diffuse alveolar hemorrhage, an early complication of stem cell transplant, results from bacterial, viral and fungal infections, coagulopathy, and engraftment syndrome, or can be idiopathic. Diffuse alveolar hemorrhage associated with Strongyloides stercoralis hyperinfection in stem cell transplant patients has been rarely reported.

Case presentation

We describe an unusual cause of alveolar hemorrhage post hematopoietic stem cell transplant due to Strongyloides hyperinfection. Therapy with parenteral ivermectin and thiabendazole was initiated but the patient deteriorated and died of respiratory failure and septic shock.

Conclusion

Strongyloides stercoralis hyperinfection is an unusual cause of alveolar hemorrhage early after hematopoietic stem cell transplant with very high mortality.
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Literature
1.
Safdar A, Malathum K, Rodriguez SJ, Husni R, Rolston KV: Strongyloidiasis in patients at a comprehensive cancer center in the United States. Cancer. 2004, 100: 1531-1536. 10.1002/cncr.20120.CrossRefPubMed
2.
Genta RM: Global prevalence of strongyloidiasis: critical review with epidemiologic insights into the prevention of disseminated disease. Rev Infect Dis. 1989, 11: 755-767.CrossRefPubMed
3.
Igra-Siegman Y, Kapila R, Sen P, Kaminski ZC, Louria DB: Syndrome of hyperinfection with Strongyloides stercoralis. Rev Infect Dis. 1981, 3: 397-407.CrossRefPubMed
4.
Kerlin RL, Nolan TJ, Schad GA: Strongyloides stercoralis: histopathology of uncomplicated and hyperinfective strongyloidiasis in the Mongolian gerbil, a rodent model for human strongyloidiasis [corrected]. Int J Parasitol. 1995, 25: 411-420. 10.1016/0020-7519(94)00154-G.CrossRefPubMed
5.
Lim S, Katz K, Krajden S, Fuksa M, Keystone JS, Kain KC: Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management. CMAJ. 2004, 171: 479-484.CrossRefPubMedPubMedCentral
6.
Orlent H, Crawley C, Cwynarski K, Dina R, Apperley J: Strongyloidiasis pre and post autologous peripheral blood stem cell transplantation. Bone Marrow Transplant. 2003, 32: 115-117. 10.1038/sj.bmt.1704104.CrossRefPubMed
7.
Concha R, Harrington W, Rogers AI: Intestinal strongyloidiasis: recognition, management, and determinants of outcome. J Clin Gastroenterol. 2005, 39: 203-211. 10.1097/01.mcg.0000152779.68900.33.CrossRefPubMed
8.
Genta RM: Predictive value of an enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of strongyloidiasis. Am J Clin Pathol. 1988, 89: 391-394.CrossRefPubMed
9.
Datry A, Hilmarsdottir I, Mayorga-Sagastume R, Lyagoubi M, Gaxotte P, Biligui S, Chodakewitz J, Neu D, Danis M, Gentilini M: Treatment of Strongyloides stercoralis infection with ivermectin compared with albendazole: results of an open study of 60 cases. Trans R Soc Trop Med Hyg. 1994, 88: 344-345. 10.1016/0035-9203(94)90110-4.CrossRefPubMed
Metadata
Title
An unusual cause of alveolar hemorrhage post hematopoietic stem cell transplantation: A case report
Authors
Sachin Gupta
Amit Jain
Tina V Fanning
Daniel R Couriel
Carlos A Jimenez
Georgie A Eapen
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-6-87

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