Skip to main content
Top
Published in: Neurological Sciences 5/2019

01-05-2019 | Letter to the Editor

An unusual case of PML in HIV patient presenting with diplopia

Authors: L. Romano, E. Capiluppi, A. Macerollo, G. Cislaghi

Published in: Neurological Sciences | Issue 5/2019

Login to get access

Excerpt

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease secondary to JC virus reactivation presenting with multifocal neurologic signs [1]. Diplopia is a neurological symptom due to dysfunction at the level of the neuromuscular junction, cranial nerves, or brainstem. Infective, autoimmune, or neoplastic/paraneoplastic diseases may cause diplopia. Here, we present a case of diplopia at the onset of PML in a patient with positivity for human immunodeficiency virus (HIV). Informed consent was obtained from the patient included in the study. …
Literature
2.
3.
go back to reference Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW (2009) Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis 9:625–636CrossRefPubMedPubMedCentral Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW (2009) Progressive multifocal leukoencephalopathy in HIV-1 infection. Lancet Infect Dis 9:625–636CrossRefPubMedPubMedCentral
4.
go back to reference Ikeda J, Matsushima A, Ishii W, Goto T, Takahashi K, Nakamichi K, Saijo M, Sekijima Y, Ikeda SI (2017) Brain biopsy is more reliable than the DNA test for JC virus in cerebrospinal fluid for the diagnosis of progressive multifocal leukoencephalopathy. Intern Med 56:1231–1234CrossRefPubMedPubMedCentral Ikeda J, Matsushima A, Ishii W, Goto T, Takahashi K, Nakamichi K, Saijo M, Sekijima Y, Ikeda SI (2017) Brain biopsy is more reliable than the DNA test for JC virus in cerebrospinal fluid for the diagnosis of progressive multifocal leukoencephalopathy. Intern Med 56:1231–1234CrossRefPubMedPubMedCentral
5.
go back to reference Ferretti F, Bestetti A, Yiannoutsos CT, Musick BS, Gerevini S, Passeri L, Bossolasco S, Boschini A, Franciotta D, Lazzarin A, Cinque P (2018) Diagnostic and prognostic value of JC virus DNA in plasma in progressive multifocal leukoencephalopathy. Clin Infect Dis 67:65–72CrossRefPubMed Ferretti F, Bestetti A, Yiannoutsos CT, Musick BS, Gerevini S, Passeri L, Bossolasco S, Boschini A, Franciotta D, Lazzarin A, Cinque P (2018) Diagnostic and prognostic value of JC virus DNA in plasma in progressive multifocal leukoencephalopathy. Clin Infect Dis 67:65–72CrossRefPubMed
6.
go back to reference Lindland ES, Solheim AM, Andreassen S, Quist-Paulsen E, Eikeland R, Ljøstad U, Mygland Å, Elsais A, Nygaard GO, Lorentzen ÅR, Harbo HF, Beyer MK (2018) Imaging in Lyme neuroborreliosis. Insights Imaging 9:833–844CrossRefPubMedPubMedCentral Lindland ES, Solheim AM, Andreassen S, Quist-Paulsen E, Eikeland R, Ljøstad U, Mygland Å, Elsais A, Nygaard GO, Lorentzen ÅR, Harbo HF, Beyer MK (2018) Imaging in Lyme neuroborreliosis. Insights Imaging 9:833–844CrossRefPubMedPubMedCentral
Metadata
Title
An unusual case of PML in HIV patient presenting with diplopia
Authors
L. Romano
E. Capiluppi
A. Macerollo
G. Cislaghi
Publication date
01-05-2019
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 5/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-018-3665-y

Other articles of this Issue 5/2019

Neurological Sciences 5/2019 Go to the issue