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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 3/2015

01-06-2015 | Bone and Diabetes (AV Schwartz and P Vestergaard, Section Editors)

An Overview of the Metabolic Functions of Osteocalcin

Authors: Jianwen Wei, Gerard Karsenty

Published in: Current Osteoporosis Reports | Issue 3/2015

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Abstract

A recent unexpected development of bone biology is that bone is an endocrine organ regulating a growing number of physiological processes. One of the functions regulated by bone through the hormone osteocalcin is glucose homeostasis. In this overview, we will explain why we hypothesized that bone mass and energy metabolism should be subjected to a coordinated endocrine regulation. We will then review the experiments that revealed the endocrine function of osteocalcin and the cell biology events that allow osteocalcin to become a hormone. We will also illustrate the importance of this regulation to understand whole-body glucose homeostasis in the physiological state and in pathological conditions. Lastly, we will mention epidemiological and genetic evidence demonstrating that this function of osteocalcin is conserved in humans.
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Metadata
Title
An Overview of the Metabolic Functions of Osteocalcin
Authors
Jianwen Wei
Gerard Karsenty
Publication date
01-06-2015
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 3/2015
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0267-y

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