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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project

Authors: Giacomo Pelizzari, Grazia Arpino, Laura Biganzoli, Saverio Cinieri, Michelino De Laurentiis, Lucia Del Mastro, Angelo Di Leo, Stefania Gori, Valentina Guarneri, Paolo Marchetti, Fabio Puglisi

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer. Based on the results of the SOFT and TEXT trials, international guidelines recommend the addition of ovarian function suppression to standard adjuvant endocrine therapy for patients at higher risk of relapse.

Methods

The ERA project (Evaluation of Risk factors in the Adjuvant treatment of breast cancer in premenopausal patients) was devised with the objective of obtaining a consensus on the identification of risk factors and the use of ovarian function suppression in the adjuvant treatment of these women. To this aim, a panel of 31 Italian oncologists with expertise in breast cancer participated in a Delphi consensus study in June 2017.

Results

A total of 29 statements related to prognostic factors, therapeutic strategies and ovarian function suppression were defined and voted to gain final consensus. For each topic we report data supporting the acquired consensus and the relevant issues discussed.

Conclusions

The SOFT and TEXT trials have changed the standard adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer, but the available treatment options require a careful risk assessment and toxicities evaluation to ensure the greatest clinical benefit for each patient.
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Metadata
Title
An Italian Delphi study to evaluate consensus on adjuvant endocrine therapy in premenopausal patients with breast cancer: the ERA project
Authors
Giacomo Pelizzari
Grazia Arpino
Laura Biganzoli
Saverio Cinieri
Michelino De Laurentiis
Lucia Del Mastro
Angelo Di Leo
Stefania Gori
Valentina Guarneri
Paolo Marchetti
Fabio Puglisi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4843-2

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