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Annals of Surgical Innovation and Research
Published in: Annals of Surgical Innovation and Research 1/2015

Open Access 01-12-2015 | Research article

An experimental study of the effect of pre-operative administration of cilostazol on random skin flap survival in rats: double blinded randomized controlled trial

Authors: Chairat Burusapat, Janjira Paengnoi, Kantang Satayasoontorn

Published in: Annals of Surgical Innovation and Research | Issue 1/2015

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Abstract

Background

Insufficient arterial blood flow is the one cause of flap necrosis. Cilostazol is an inhibitor of phosphodiesterase III and increases cyclic AMP level in vascular smooth muscle cell causing vasodilation. Therefore, effect of cilostazol is expected to improve the viability of the flap.

Methods

Double blinded randomized controlled trial was conducted. The study was to compare the survival of dorsal rat flaps between preoperative cilostazol supplemented diet and regular diet. The flap survival area was measured using PixArea Image software on post operative day 1,3,5 and 7. Fluorescein injection was performed to evaluate the exactly area of flap survival on postoperative day 7 and morphology of arterioles and venules were examined by histopathologic examination.

Results

A statistical significance was found in the percentage of area of flap survival between cilostazol supplemented diet and control group on postoperative day 3, 5 and 7 (p < 0.05). Fluorescein injection showed the higher area of flap survival in cilostazol group than the control group (p < 0.05). Histopathologic examination showed dilation of vessels in the cilostazol group.

Conclusion

Preoperative cilostazol in rats can enhance skin flap survival.
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Metadata
Title
An experimental study of the effect of pre-operative administration of cilostazol on random skin flap survival in rats: double blinded randomized controlled trial
Authors
Chairat Burusapat
Janjira Paengnoi
Kantang Satayasoontorn
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Annals of Surgical Innovation and Research / Issue 1/2015
Electronic ISSN: 1750-1164
DOI
https://doi.org/10.1186/s13022-015-0011-4

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