Published in:
01-08-2012 | Head and Neck
An essential dose of cisplatin for super-selective intra-arterial infusion concomitant with radiotherapy in patient with maxillary squamous cell carcinoma
Authors:
Yuji Kanazawa, Hideo Shojaku, Hiromasa Takakura, Michiro Fujisaka, Hirohiko Tachino, Yukio Watanabe, Gakuto Tomizawa, Hideto Kawabe, Hiroko Shojaku, Hikaru Seto, Kyoko Otani, Jyunya Fukuoka
Published in:
European Archives of Oto-Rhino-Laryngology
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Issue 8/2012
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Abstract
The present study investigated the efficacy and safety of using a lower dose of cisplatin (CDDP) in super-selective intra-arterial concurrent chemoradiotherapy (SSIACRT) to treat maxillary squamous cell carcinoma. 10 patients with maxillary squamous cell carcinoma (T3 n = 6, T4a n = 4) without regional or distant metastasis were treated by SSIACRT. The CDDP dose per course was 100 mg/body, i.e. 50–80 mg/m2. 6–9 weeks after SSIACRT, partial maxillectomy was performed on all patients. Clinical and histological responses, survival rates, and adverse events were investigated. 10 (100%) of 10 patients achieved both clinical and pathological complete or partial remission. The 3-year overall and disease-free survival rates were 100 and 90%, respectively. Grade 3 toxicity was experienced by two patients. In conclusion, the SSIACRT regimen with a lower dose of CDDP (100 mg/body) had an equivalent therapeutic outcome and lower toxic outcome compared to a higher dose of CDDP. This regimen could be an effective and safe therapeutic modality for maxillary squamous cell carcinoma except T4b and N1/2 disease.