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BMC Oral Health

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Open Access 01-12-2023 | Research

An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma

Authors: Yinting Ren, Junlong Da, Junyu Ren, Ye Song, Jingying Han

Published in: BMC Oral Health | Issue 1/2023

Abstract

Background

Tongue squamous cell carcinoma (TSCC) is the most common oral cancer with a poor prognosis. At present, there is not any systematic study on autophagy-related long non-coding RNA (lncRNA) to predict the survival of patients with TSCC.

Material and methods

In this research, the cohort of TSCC patients were obtained from The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analysis showed that ten lncRNAs related to autophagy AC010326.3, AL160006.1, AL122010.1, AC139530.1, AC092747.4, AL139287.1, MIR503HG, AC009318.2, LINC01711, and LINC02560 are significantly correlated with prognosis. Based on these lncRNAs, a prognostic signature was established. This signature has an AUC value of 0.782, which accurately distinguishes patients of TSCC into high-risk and low-risk groups in different clinical hierarchical information (such as gender, age, etc.).

Results

The clinical nomogram with autophagy-related lncRNA prognostic characteristics has a concordance index of 0.81, and accurately predicts the survival time at 1-year and 3-year of TSCC patients. Related functional enrichment results indicate that the pathways of the high-risk group are enriched on cancer and autophagy.

Conclusions

The autophagy-related lncRNA prognostic signature established in this study could accurately predict the prognosis of TSCC patients and may be a molecular biomarker and therapeutic target.

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Title: An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma
Authors: Yinting Ren
Junlong Da
Junyu Ren
Ye Song
Jingying Han
Publication date: 01-12-2023
Publisher: BioMed Central
Published in: BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-023-02806-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

An autophagy-related long non-coding RNA signature in tongue squamous cell carcinoma

Abstract

Background

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Material and methods

Results

Conclusions

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