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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 3/2017

Open Access 01-04-2017 | Original Article

An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using 18F-FDG-PET and 11C-methionine PET

Authors: Miwako Takahashi, Tsutomu Soma, Akitake Mukasa, Keitaro Koyama, Takuya Arai, Toshimitsu Momose

Published in: Annals of Nuclear Medicine | Issue 3/2017

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Abstract

Objective

The tumour-to-normal ratio (T/N) is a representative index reflecting brain tumour activity by 18F-fluorodeoxyglucose (FDG) and 11C-methionine (MET) PET. We proposed a new automated method of calculating the normal reference value (N-value) for use as the denomination of T/N. This method uses voxel-based analysis of FDG- and MET-PET images. We compared the results of this method with those of the standard region-of-interest (ROI) method.

Methods

Data sets were obtained from 32 patients with newly diagnosed glioma and 13 patients with recurrent brain tumour. Our methods were as follows: (1) FDG-PET and MET-PET images were co-registered. (2) The areas where the FDG uptake was higher than a set threshold were selected. (3) For the corresponding areas of MET-PET images, mode and mean voxel values were calculated as tentative MET N-values. (4) Applying the same coordinates to FDG-PET, the voxel values were averaged and used as tentative FDG N-values. (5) The threshold of FDG-PET and whether to use the mode or the mean voxel values were computationally optimized using learning data sets. (6) Applying the optimal threshold and either the mode or mean, N-values of FDG and MET were finally determined.

Results

N-values determined by our automated method showed excellent agreement with those determined by a manual ROI method (ICC(2,1) > 0.78). These values were significantly correlated with mean manual N-values (p < 0.001).

Conclusions

Our new method shows sufficiently good agreement with the standard method and can provide a more objective metabolic index.
Appendix
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Metadata
Title
An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using 18F-FDG-PET and 11C-methionine PET
Authors
Miwako Takahashi
Tsutomu Soma
Akitake Mukasa
Keitaro Koyama
Takuya Arai
Toshimitsu Momose
Publication date
01-04-2017
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 3/2017
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-017-1153-8

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