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Open Access 01-12-2006 | Research article

An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy

Authors: Yuhua Song, Santai Song, Dong Zhang, Yan Zhang, Liyong Chen, Lu Qian, Ming Shi, Huibin Zhao, Zefei Jiang, Ning Guo

Published in: BMC Cancer | Issue 1/2006

Abstract

Background

Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis.

Methods

The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed.

Results

All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas.

Conclusion

The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/6/298/prepub

Title: An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy
Authors: Yuhua Song
Santai Song
Dong Zhang
Yan Zhang
Liyong Chen
Lu Qian
Ming Shi
Huibin Zhao
Zefei Jiang
Ning Guo
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2006
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-6-298

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