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Neurosurgical Review
Published in: Neurosurgical Review 1/2015

01-01-2015 | Review

An adult multifocal medulloblastoma with diffuse acute postoperative cerebellar swelling: immunohistochemical and molecular genetics analysis

Authors: Vladimir Balik, Radek Trojanec, Milena Holzerova, Lucie Tuckova, Igor Sulla, Magdalena Megova, Miroslav Vaverka, Lumir Hrabalek, Jiri Ehrmann

Published in: Neurosurgical Review | Issue 1/2015

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Abstract

Medulloblastoma (MB), the most common malignant tumor typically affecting children, occurs only exceptionally in adults. Multifocal presentation of this malignancy in adulthood is even much rarer—only four cases with favorable postoperative course have been reported, so far. The study illustrates a very rare rapid postoperative clinical deterioration due to diffuse cerebellar swelling (DCS) in an adult multifocal MB (MMB). To the best of their knowledge, authors for the first time performed genetic analysis of MMB and demonstrated expression patterns of selected markers that put the patient within the sonic hedgehog (SHH) molecular subgroup and at least partially explain her unsatisfactory clinical course. Herein, authors summarized the relevant literature concerning this issue with the aim to determine features that would facilitate diagnosis and therapy of such a scarce clinical entity.
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Metadata
Title
An adult multifocal medulloblastoma with diffuse acute postoperative cerebellar swelling: immunohistochemical and molecular genetics analysis
Authors
Vladimir Balik
Radek Trojanec
Milena Holzerova
Lucie Tuckova
Igor Sulla
Magdalena Megova
Miroslav Vaverka
Lumir Hrabalek
Jiri Ehrmann
Publication date
01-01-2015
Publisher
Springer Berlin Heidelberg
Published in
Neurosurgical Review / Issue 1/2015
Print ISSN: 0344-5607
Electronic ISSN: 1437-2320
DOI
https://doi.org/10.1007/s10143-014-0556-4

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