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Cancer Cell International
Published in: Cancer Cell International 1/2018

Open Access 01-12-2018 | Primary research

An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma

Authors: Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen, Chien-Ming Lo, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai, Chang-Han Chen

Published in: Cancer Cell International | Issue 1/2018

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Abstract

Background

ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Recent few studies show that ESPN regulates metastasis and cell proliferation in melanoma. However, the significance of ESPN in other cancers such as esophageal squamous cell carcinoma (ESCC) remains largely unknown.

Methods

Immunohistochemistry was performed in 169 patients with ESCC and correlated with clinicopathological features and survival. The functional role of ESPN in ESCC cells was determined by ESPN-mediated siRNA.

Results

Univariate analyses showed that high ESPN expression was associated with inferior overall survival (P = 0.005) and disease-free survival (P = 0.035). High ESPN expression was an independent prognosticator in multivariate analysis for overall survival (P = 0.009, hazard ratio = 1.688) and disease-free survival (P = 0.049, hazard ratio = 1.451). The 5-year overall survival rates were 30% and 54% in patients with high and low expression of ESPN, respectively. Inhibition of endogenous ESPN in ESCC cells decreased ESCC growth by reducing cell proliferating rates.

Conclusions

High ESPN expression is independently associated with poor prognosis in patients with ESCC and downregulation of ESPN inhibits ESCC cell growth. Our results suggest that ESPN may be a novel therapeutic target for patients with ESCC.
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Metadata
Title
An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma
Authors
Shau-Hsuan Li
Hung-I Lu
Wan-Ting Huang
Yen-Hao Chen
Chien-Ming Lo
Ya-Chun Lan
Wei-Che Lin
Hsin-Ting Tsai
Chang-Han Chen
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2018
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-018-0713-x

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