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01-09-2018 | Original Article

Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia

Authors: Takayuki Kikukawa, Takato Abe, Suzuka Ataka, Haruna Saito, Itsuki Hasegawa, Toshikazu Mino, Jun Takeuchi, Joji Kawabe, Yasuhiro Wada, Yasuyoshi Watanabe, Yoshiaki Itoh

Published in: Neurological Sciences | Issue 9/2018

Abstract

Mild cognitive impairment (MCI) can include the transition from a normal state to dementia. To explore biomarkers for the development of dementia, we performed an 18-month follow-up study in 28 patients with amnestic MCI. Amyloid deposition was examined using PiB PET, and cerebral blood flow (CBF) was examined using SPECT. Cognitive function was periodically assessed. The rate of conversion to dementia was higher in the PiB-positive/equivocal group (74%) than in the PiB-negative group (33%) (p = 0.041). Perfusion SPECT was performed in 16 patients. MCI patients with an AD-characteristic pattern of reduced CBF had a higher PiB-positive/equivocal rate (82%) than those with a non-AD pattern (20%) (p = 0.018), and patients with an AD pattern had a higher conversion rate (82%) than those with a non-AD pattern (40%) (p = 0.094). Clinically, all PiB-positive converters were diagnosed as having Alzheimer’s disease (AD), whereas PiB-negative converters were thought to have some form of dementia other than AD. Amyloid PET is useful for predicting conversion to AD in MCI patients. A pattern analysis of perfusion SPECT findings might also be helpful for predicting conversion to AD, but with a lower specificity.

Boyle PA, Wilson RS, Aggarwal NT, Tang Y, Bennett DA (2006) Mild cognitive impairment: risk of Alzheimer disease and rate of cognitive decline. Neurology 67(3):441–445CrossRefPubMed

Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B (2001) Current concepts in mild cognitive impairment. Arch Neurol 58(12):1985–1992CrossRefPubMed

Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Langstrom B (2004) Imaging brain amyloid in Alzheimer’s disease with Pittsburgh compound-B. Ann Neurol 55(3):306–319CrossRefPubMed

Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, Lopresti BJ, Ziolko S, Bi W, Paljug WR, Debnath ML, Hope CE, Isanski BA, Hamilton RL, DeKosky ST (2008) Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer’s disease. Brain 131(Pt 6):1630–1645CrossRefPubMedPubMedCentral

Devanand DP, Liu X, Tabert MH, Pradhaban G, Cuasay K, Bell K, de Leon MJ, Doty RL, Stern Y, Pelton GH (2008) Combining early markers strongly predicts conversion from mild cognitive impairment to Alzheimer’s disease. Biol Psychiatry 64(10):871–879CrossRefPubMedPubMedCentral

Klunk WE, Mathis CA, Price JC, Lopresti BJ, DeKosky ST (2006) Two-year follow-up of amyloid deposition in patients with Alzheimer’s disease. Brain 129(Pt 11):2805–2807CrossRefPubMed

Forsberg A, Engler H, Almkvist O, Blomquist G, Hagman G, Wall A, Ringheim A, Langstrom B, Nordberg A (2008) PET imaging of amyloid deposition in patients with mild cognitive impairment. Neurobiol Aging 29(10):1456–1465CrossRefPubMed

Koivunen J, Scheinin N, Virta JR, Aalto S, Vahlberg T, Nagren K, Helin S, Parkkola R, Viitanen M, Rinne JO (2011) Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study. Neurology 76(12):1085–1090CrossRefPubMed

Okello A, Koivunen J, Edison P, Archer HA, Turkheimer FE, Nagren K, Bullock R, Walker Z, Kennedy A, Fox NC, Rossor MN, Rinne JO, Brooks DJ (2009) Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study. Neurology 73(10):754–760CrossRefPubMedPubMedCentral

10.

Davison CM, O’Brien JT (2014) A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review. Int J Geriatr Psychiatry 29(6):551–561CrossRefPubMed

11.

Pimlott SL, Ebmeier KP (2007) SPECT imaging in dementia. Br J Radio 80 Spec No 2:S153–S159CrossRef

12.

Jagust W, Thisted R, Devous MD Sr, Van Heertum R, Mayberg H, Jobst K, Smith AD, Borys N (2001) SPECT perfusion imaging in the diagnosis of Alzheimer’s disease: a clinical-pathologic study. Neurology 56(7):950–956CrossRefPubMed

13.

Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, de Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack C, Jorm A, Ritchie K, van Duijn C, Visser P, Petersen RC (2004) Mild cognitive impairment—beyond controversies, towards a consensus: report of the international working group on mild cognitive impairment. J Intern Med 256(3):240–246CrossRefPubMed

14.

McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH (2011) The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7(3):263–269CrossRefPubMedPubMedCentral

15.

T. Mino, H. Saito, J. Takeuchi, K. Ito, A. Takeda, S. Ataka, S. Shiomi, Y. Wada, Y. Watanabe, Y. Itoh (2016) Cerebral blood flow abnormality in clinically diagnosed Alzheimer’s disease patients with or without amyloid β accumulation on positron emission tomography. Neurol Clin Neurosci 5(2):55–59CrossRef

16.

Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA, Price JC, Reiman EM, Skovronsky D, Koeppe RA, I. Alzheimer’s Disease Neuroimaging (2010) The Alzheimer’s disease neuroimaging initiative positron emission tomography core. Alzheimers Dement 6(3):221–229CrossRefPubMedPubMedCentral

17.

Silverman DH, Small GW, Chang CY, Lu CS, Kung De Aburto MA, Chen W, Czernin J, Rapoport SI, Pietrini P, Alexander GE, Schapiro MB, Jagust WJ, Hoffman JM, Welsh-Bohmer KA, Alavi A, Clark CM, Salmon E, de Leon MJ, Mielke R, Cummings JL, Kowell AP, Gambhir SS, Hoh CK, Phelps ME (2001) Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA 286(17):2120–2127CrossRefPubMed

18.

Johnson KA, Minoshima S, Bohnen NI, Donohoe KJ, Foster NL, Herscovitch P, Karlawish JH, Rowe CC, Carrillo MC, Hartley DM, Hedrick S, Pappas V, Thies WH (2013) Appropriate use criteria for amyloid PET: a report of the amyloid imaging task force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer’s Association. J Nucl Med 54(3):476–490CrossRefPubMed

19.

Busse A, Hensel A, Guhne U, Angermeyer MC, Riedel-Heller SG (2006) Mild cognitive impairment: long-term course of four clinical subtypes. Neurology 67(12):2176–2185CrossRefPubMed

20.

Rasquin SM, Lodder J, Visser PJ, Lousberg R, Verhey FR (2005) Predictive accuracy of MCI subtypes for Alzheimer’s disease and vascular dementia in subjects with mild cognitive impairment: a 2-year follow-up study. Dement Geriatr Cogn Disord 19(2–3):113–119CrossRefPubMed

21.

Park SJ, Lee JE, Lee KS, Kim JS (2018) Comparison of odor identification among amnestic and non-amnestic mild cognitive impairment, subjective cognitive decline, and early Alzheimer’s dementia. Neurol Sci 39(3):557–564CrossRefPubMed

22.

Yamada M, Itoh Y, Sodeyama N, Suematsu N, Otomo E, Matsushita M, Mizusawa H (2001) Senile dementia of the neurofibrillary tangle type: a comparison with Alzheimer’s disease. Dement Geriatr Cogn Disord 12(2):117–126CrossRefPubMed

23.

Alegret M, Cuberas-Borros G, Vinyes-Junque G, Espinosa A, Valero S, Hernandez I, Roca I, Ruiz A, Rosende-Roca M, Mauleon A, Becker JT, Castell-Conesa J, Tarraga L, Boada M (2012) A two-year follow-up of cognitive deficits and brain perfusion in mild cognitive impairment and mild Alzheimer’s disease. J Alzheimers Dis 30(1):109–120CrossRefPubMedPubMedCentral

Title: Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia
Authors: Takayuki Kikukawa
Takato Abe
Suzuka Ataka
Haruna Saito
Itsuki Hasegawa
Toshikazu Mino
Jun Takeuchi
Joji Kawabe
Yasuhiro Wada
Yasuyoshi Watanabe
Yoshiaki Itoh
Publication date: 01-09-2018
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 9/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-018-3477-0

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Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia

Abstract

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