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Neurocritical Care

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01-06-2008 | PRACTICAL PEARL

Amplification of Acute Focal Ischemic Deficit by Narcotics

Authors: Jordan Dubow, Richard A. Bernstein

Published in: Neurocritical Care | Issue 3/2008

Abstract

Introduction

This article describes two patients with major ischemic stroke symptoms who had extremely small areas of acute brain infarction, suggestive of acute intrahemispheric diaschisis. Both patients were using narcotic analgesics during their stroke, and in both cases the clinical deficits improved dramatically with naloxone.

Discussion

We postulate that the narcotics amplified the ischemic stroke symptoms and that this effect was antagonized by naloxone.

Conclusion

This suggests that the opiate system may be involved in the process of intrahemispheric diaschisis.

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Title: Amplification of Acute Focal Ischemic Deficit by Narcotics
Authors: Jordan Dubow
Richard A. Bernstein
Publication date: 01-06-2008
Publisher: Humana Press Inc
Published in: Neurocritical Care / Issue 3/2008
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI: https://doi.org/10.1007/s12028-007-9023-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Amplification of Acute Focal Ischemic Deficit by Narcotics

Abstract

Introduction

Discussion

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Discussion

Conclusion

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