Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Oral Health
Published in: BMC Oral Health 1/2018

Open Access 01-12-2018 | Case report

Amelogenesis imperfecta: therapeutic strategy from primary to permanent dentition across case reports

Authors: Steve Toupenay, Benjamin Philippe Fournier, Marie-Cécile Manière, Chantal Ifi-Naulin, Ariane Berdal, Muriel de La Dure– Molla

Published in: BMC Oral Health | Issue 1/2018

Login to get access

Abstract

Background

Hereditary enamel defect diseases are regrouped under the name “Amelogenesis Imperfecta” (AIH). Both dentitions are affected. Clinical expression is heterogeneous and varies between patients. Mutations responsible for this multigene disease may alter various genes and the inheritance can be either autosomal dominant or recessive, or X-linked. Until now, no therapeutic consensus has emerged for this rare disease.

Case presentation

The purpose of this article was to report treatments of AIH patients from childhood to early adulthood. Treatment of three patients of 3, 8 16 years old are described. Each therapeutic option was discussed according to patients’ age and type of enamel alteration. Paediatric crowns and resin based bonding must be preferred in primary teeth. In permanent teeth, non-invasive or minimally invasive dentistry should be the first choice in order to follow a therapeutic gradient from the less invasive options to prosthodontic treatments.

Conclusion

Functional and aesthetic issues require patients to be treated; this clinical care should be provided as early as possible to enable a harmonious growth of the maxillofacial complex and to prevent pain.
Literature
1.
Slayton RL, Warren JJ, Kanellis MJ, Levy SM, Islam M. Prevalence of enamel hypoplasia and isolated opacities in the primary dentition. Pediatr Dent. 2001;23:32–6.PubMed
2.
Jedeon K, De la Dure-Molla M, Brookes SJ, Loiodice S, Marciano C, Kirkham J, Canivenc-Lavier MC, Boudalia S, Berges R, Harada H, et al. Enamel defects reflect perinatal exposure to bisphenol A. Am J Pathol. 2013;183:108–18.CrossRefPubMedPubMedCentral
3.
Smith CEL, Poulter JA, Antanaviciute A, Kirkham J, Brookes SJ, Inglehearn CF, Mighell AJ. Amelogenesis Imperfecta; genes, proteins, and pathways. Front Physiol. 2017;8:435.CrossRefPubMedPubMedCentral
4.
Witkop CJ Jr. Amelogenesis imperfecta, dentinogenesis imperfecta and dentin dysplasia revisited: problems in classification. Journal of oral pathology. 1988;17:547–53.CrossRefPubMed
5.
Wright JT, Robinson C, Kirkham J. Enamel protein in smooth hypoplastic amelogenesis imperfecta. Pediatr Dent. 1992;14:331–7.PubMed
6.
Wright JT, Lord V, Robinson C, Shore R. Enamel ultrastructure in pigmented hypomaturation amelogenesis imperfecta. J Oral Pathol & medicine : official publi of the Int Ass of Oral Pathologists and the Am Acad Oral Pathol. 1992;21:390–4.CrossRef
7.
El-Sayed W, Shore RC, Parry DA, Inglehearn CF, Mighell AJ. Hypomaturation Amelogenesis Imperfecta due to WDR72 mutations: a novel mutation and Ultrastructural analyses of deciduous teeth. Cells Tissues Organs. 2009;85:699–705.
8.
McDonald S, Arkutu N, Malik K, Gadhia K, McKaig S. Managing the paediatric patient with amelogenesis imperfecta. Br Dent J. 2012;212:425–8.CrossRefPubMed
9.
Poulsen S, Gjorup H, Haubek D, Haukali G, Hintze H, Lovschall H, Errboe M. Amelogenesis imperfecta - a systematic literature review of associated dental and oro-facial abnormalities and their impact on patients. Acta Odontol Scand. 2008;66:193–9.CrossRefPubMed
10.
Aldred MJ, Crawford PJ. Variable expression in Amelogenesis imperfecta with taurodontism. J Oral Pathol. 1988;17:327–33.CrossRefPubMed
11.
Pavlic A, Battelino T, Trebusak Podkrajsek K, Ovsenik M. Craniofacial characteristics and genotypes of amelogenesis imperfecta patients. Eur J Orthod. 2011;33:325–31.
12.
Ravassipour DB, Powell CM, Phillips CL, Hart PS, Hart TC, Boyd C, Wright JT. Variation in dental and skeletal open bite malocclusion in humans with amelogenesis imperfecta. Arch Oral Biol. 2005;50:611–23.CrossRefPubMed
13.
de Souza-e-Silva CM, Parisotto TM, Steiner-Oliveira C, Gaviao MB, Nobre-Dos-Santos M. Oral rehabilitation of primary dentition affected by amelogenesis imperfecta: a case report. J Contemp Dent Pract. 2010;11:071–7.PubMed
14.
Mackie IC, Blinkhorn AS. Amelogenesis imperfecta: early interception to prevent attrition. Dental update. 1991;18:79–80.PubMed
15.
American Academy on Pediatric Dentistry Council on Clinical Affairs. (2008-2009). Guideline on oral heath care/dental management of heritable dental development anomalies. Pediatr Dent 30, 196–201.
16.
Parekh S, Almehateb M, Cunningham SJ. How do children with amelogenesis imperfecta feel about their teeth? Int J Paediatr D / Br Paedod Soc [and] the Int Assoc Dent Child. 2014;24:326–35.
17.
Coffield KD, Phillips C, Brady M, Roberts MW, Strauss RP, Wright JT. The psychosocial impact of developmental dental defects in people with hereditary amelogenesis imperfecta. J Am Dent Assoc. 2005;136:620–30.CrossRefPubMed
18.
Pugach MK, Ozer F, Li Y, Sheth K, Beasley R, Resnick A, Daneshmehr L, Kulkarni AB, Bartlett JD, Gibson CW, et al. The use of mouse models to investigate shear bond strength in amelogenesis imperfecta. J Dent Res. 2011;90:1352–7.CrossRefPubMedPubMedCentral
19.
Seow WK, Amaratunge A. The effects of acid-etching on enamel from different clinical variants of amelogenesis imperfecta: an SEM study. Pediatr Dent. 1998;20:37–42.PubMed
20.
Saroglu I, Aras S, Oztas D. Effect of deproteinization on composite bond strength in hypocalcified amelogenesis imperfecta. Oral Dis. 2006;12:305–8.CrossRefPubMed
21.
Sonmez IS, Aras S, Tunc ES, Kucukesmen C. Clinical success of deproteinization in hypocalcified amelogenesis imperfecta. Quintessence Int. 2009;40:113–8.PubMed
22.
Venezie RD, Vadiakas G, Christensen JR, Wright JT. Enamel pretreatment with sodium hypochlorite to enhance bonding in hypocalcified amelogenesis imperfecta: case report and SEM analysis. Pediatr Dent. 1994;16:433–6.PubMed
23.
Faria, E.S.A.L., De Moraes, R.R., De Sousa Menezes, M., Capanema, R.R., De Moura, A.S., and Martelli-Junior, H. (2011). Hardness and microshear bond strength to enamel and dentin of permanent teeth with hypocalcified amelogenesis imperfecta. International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children. 2011;21:314–20.
24.
Sanchez-Quevedo MC, Ceballos G, Garcia JM, Luna JD, Rodriguez IA, Campos A. Dentine structure and mineralization in hypocalcified amelogenesis imperfecta: a quantitative X-ray histochemical study. Oral Dis. 2004;10:94–8.CrossRefPubMed
25.
Pires Dos Santos AP, Cabral CM, Moliterno LF, Oliveira BH. Amelogenesis imperfecta: report of a successful transitional treatment in the mixed dentition. J Dent Child. 2008;75:201–6.
26.
Ng FK, Messer LB. Dental management of amelogenesis imperfecta patients: a primer on genotype-phenotype correlations. Pediatr Dent. 2009;31:20–30.PubMed
27.
Pousette Lundgren G, Morling Vestlund GI, Trulsson M, Dahllof G. A randomized controlled trial of crown therapy in young individuals with Amelogenesis Imperfecta. J Dent Res. 2015;94:1041–7.CrossRefPubMed
28.
Chan KH, Ho EH, Botelho MG, Pow EH. Rehabilitation of amelogenesis imperfecta using a reorganized approach: a case report. Quintessence Int. 2011;42:385–91.PubMed
29.
Doruk C, Ozturk F, Sari F, Turgut M. Restoring function and aesthetics in a class II division 1 patient with Amelogenesis Imperfecta: a clinical report. European journal of dentistry. 2011;5:220–8.PubMedPubMedCentral
30.
Gisler V, Enkling N, Zix J, Kim K, Kellerhoff NM, Mericske-Stern R. A multidisciplinary approach to the functional and esthetic rehabilitation of amelogenesis imperfecta and open bite deformity: a case report. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry [et al]. 2010;22:282–93.CrossRef
31.
Ramos AL, Pascotto RC, Iwaki Filho L, Hayacibara RM, Boselli G. Interdisciplinary treatment for a patient with open-bite malocclusion and amelogenesis imperfecta. American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics. 2011;139:S145–53.CrossRef
32.
Robinson FG, Haubenreich JE. Oral rehabilitation of a young adult with hypoplastic amelogenesis imperfecta: a clinical report. J Prosthet Dent. 2006;95:10–3.CrossRefPubMed
33.
Zarati S, Ahmadian L, Arbabi R. A transitional overlay partial denture for a young patient: a clinical report. Journal of prosthodontics : official journal of the American College of Prosthodontists. 2009;18:76–9.CrossRef
34.
Saito M, Notani K, Miura Y, Kawasaki T. Complications and failures in removable partial dentures: a clinical evaluation. J Oral Rehabil. 2002;29:627–33.CrossRefPubMed
35.
Sabatini C, Guzman-Armstrong S. A conservative treatment for amelogenesis imperfecta with direct resin composite restorations: a case report. Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry [et al]. 2009;21:161–9. discussion 170CrossRef
36.
Brignall, I., Mehta, S.B., Banerji, S., and Millar, B.J. (2011). Aesthetic composite veneers for an adult patient with amelogenesis imperfecta: a case report. Dental update 38, 594–596, 598–600, 603.
37.
Oliveira IK, Fonseca Jde F, do Amaral FL, Pecorari VG, Basting RT, Franca FM. Diagnosis and esthetic functional rehabilitation of a patient with amelogenesis imperfecta. Quintessence Int. 2011;42:463–9.PubMed
38.
Turkun LS. Conservative restoration with resin composites of a case of amelogenesis imperfecta. Int Dent J. 2005;55:38–41.CrossRefPubMed
39.
Lygidakis NA, Chaliasou A, Siounas G. Evaluation of composite restorations in hypomineralised permanent molars: a four year clinical study. Eur J Paediatr Dent. 2003;4:143–8.PubMed
40.
Lindunger A, Smedberg JI. A retrospective study of the prosthodontic management of patients with amelogenesis imperfecta. Int J Prosthodont. 2005;18:189–94.PubMed
41.
Pousette Lundgren G, Dahllof G. Outcome of restorative treatment in young patients with amelogenesis imperfecta. A cross-sectional, retrospective study. J Dent. 2014;42:1382–9.CrossRefPubMed
42.
Krieger O, Matuliene G, Husler J, Salvi GE, Pjetursson B, Bragger U. Failures and complications in patients with birth defects restored with fixed dental prostheses and single crowns on teeth and/or implants. Clin Oral Implants Res. 2009;20:809–16.CrossRefPubMed
43.
Incici E, Matuliene G, Husler J, Salvi GE, Pjetursson B, Bragger U. Cumulative costs for the prosthetic reconstructions and maintenance in young adult patients with birth defects affecting the formation of teeth. Clin Oral Implants Res. 2009;20:715–21.CrossRefPubMed
44.
Sockalingam S. Dental rehabilitation of amelogenesis imperfecta using thermoformed templates. J Indian Soc Pedod Prev Dent. 2011;29(1):53–6.
45.
Manhart J, Neuerer P, Scheibenbogen-Fuchsbrunner A, Hickel R. Three-year clinical evaluation of direct and indirect composite restorations in posterior teeth. J Prosthet Dent. 2000;84(3):289–96.
46.
Koyuturk AE, Ozmen B, Tokay U, Tuloglu N, Sari ME, Sonmez TT. Two-year follow-up of indirect posterior composite restorations of permanent teeth with excessive material loss in pediatric patients: a clinical study. J Adhes Dent. 2013;15(6):583–90.
47.
Fasbinder DJ. Clinical performance of chairside CAD/CAM restorations. J Am Dent Assoc. 2006;137(Suppl:22S-31S). Review.
48.
Schlichting LH1, Maia HP, Baratieri LN, Magne P. Novel-design ultra-thin CAD/CAM composite resin and ceramic occlusal veneers for the treatment of severe dental erosion. J Prosthet Dent. 2011;105(4):217–26.
Metadata
Title
Amelogenesis imperfecta: therapeutic strategy from primary to permanent dentition across case reports
Authors
Steve Toupenay
Benjamin Philippe Fournier
Marie-Cécile Manière
Chantal Ifi-Naulin
Ariane Berdal
Muriel de La Dure– Molla
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2018
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-018-0554-y

Other articles of this Issue 1/2018

BMC Oral Health 1/2018 Go to the issue

Case report

Fully digital workflow, integrating dental scan, smile design and CAD-CAM: case report

Research article

The association between nutritive, non-nutritive sucking habits and primary dental occlusion

Research article

Parenting and oral health in an inner-city environment: a qualitative pilot study

Research article

The effect of smear layer removal on E. faecalis leakage and bond strength of four resin-based root canal sealers

Research article

Predicting oral malodour based on the microbiota in saliva samples using a deep learning approach

Research article

Influence of denture surface roughness and host factors on dental calculi formation on dentures: a cross-sectional study