Top

Published in:

01-09-2018 | Original Article

Ameliorating effect of edible bird’s nest against lead acetate toxicity on the rat hypothalamic–pituitary–ovarian axis and expressions of epidermal growth factor and vascular endothelial growth factor in ovaries

Authors: Abdulla A. Albishtue, Nurhusien Yimer, Md Zuki A. Zakaria, Abd Wahid Haron, Rosnina Yusoff, Bahaa H. Almhanawi

Published in: Comparative Clinical Pathology | Issue 5/2018

Abstract

Lead acetate (LA) alters ovarian histology, size and function, as well as decreases oestrogen production. LA is also toxic to rat ovary and pituitary gland. Edible bird’s nest (EBN) can reportedly alleviate these damages. This study aimed to evaluate the protective effect of EBN supplement on the ovaries and pituitary glands of rats exposed to LA toxicity. Five treatment groups were established as follows: group 1 (C), which was given distilled water; group 2 (T0), which was administered with LA (10 mg/kg body weight (BW); and groups 3 (T1), 4 (T2) and 5 (T3), which were given LA (10 mg/kg BW) plus graded concentrations of 30, 60 and 120 mg/kg BW of EBN, respectively. Rats were euthanised at day 35 to collect ovary and pituitary gland for histomorphological study and the expression analysis of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF). Plasma was used to determine concentrations of E₂, progesterone (P₄), growth hormone (GH) and prolactin (P). E₂, P₄, GH and P levels were lower (p < 0.05) in T0, whereas T3 had the highest E₂ concentration. All EBN-treated groups had increased number of survival follicles, as well as significant proliferation of gonadotrophic cells in the pituitary gland and decreased degenerative changes. All immunohistochemistry results showed significantly higher EGF and VEGF expression levels (p < 0.05) in T3. Overall, results showed the detrimental effects of LA on the ovary and pituitary gland and revealed the ameliorating effect of oral EBN supplementation against LA toxicity.

Agarwal A, Gupta S, Sharma RK (2005) Role of oxidative stress in female reproduction. Reprod Biol Endocrinol 3(1):28CrossRefPubMedPubMedCentral

Albishtue A, Yimer N, Zakaria M, Haron A, Yusoff R, Assi M, Almhanawi B (2018) Edible bird’s nest impact on rats’ uterine histomorphology, expressions of genes of growth factors and proliferating cell nuclear antigen, and oxidative stress level. Vet World 11(1):71–79CrossRefPubMedPubMedCentral

Anasti J, Kalantaridou S, Kimzey L, George M, Nelson L (1998) Human follicle fluid vascular endothelial growth factor concentrations are correlated with luteinization in spontaneously developing follicles. Hum Reprod 13(5):1144–1147CrossRefPubMed

Assi M, Hezmee M, Abba Y, Rajion M, Wahid H, Yusof M (2017) Assessment of therapeutic effects of Nigella sativa against chronic lead acetate-induced reproductive dysfunction in male Sprague-Dawley rats. Comp Clin Pathol 26(1):87–97CrossRef

Christenson LK, Stouffer RL (1997) Follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin stimulation of vascular endothelial growth factor production by macaque granulosa cells from pre-and periovulatory follicles. J Clin Endocrinol Metabol 82(7):2135–2142

Dickson SE, Fraser HM (2000) Inhibition of early luteal angiogenesis by gonadotropin-releasing hormone antagonist treatment in the primate. J Clin Endocrinol Metabol 85(6):2339–2344CrossRef

Drummond AE (2006) The role of steroids in follicular growth. Reprod Biol Endocrinol 4(1):16CrossRefPubMedPubMedCentral

Flora SJS, Pachauri V, Saxena G (2011) Arsenic, cadmium and lead. In: Gupta RC (ed) Reproductive and developmental toxicology. Academic Press, Elsevier Inc, London, pp 415–438CrossRef

Guzeloglu-Kayisli O, Kayisli UA, Taylor HS (2009) The role of growth factors and cytokines during implantation: endocrine and paracrine interactions. Semin Reprod Med 27(1):62–79CrossRefPubMedPubMedCentral

Hamadouche NA, Nesrine S, Abdelkeder A (2013) Lead toxicity and the hypothalamic-pituitary-testicular axis. Notulae Scientia Biologicae 5(1):1CrossRef

Hillier SG, DE Zwart FA (1981) Evidence that granulosa cell aromatase induction/activation by follicle-stimulating hormone is an androgen receptor-regulated process in-vitro. Endocrinology 109(4):1303–1305CrossRefPubMed

Hillier SG, Knazek RA, Ross GT (1977) Androgenic stimulation of progesterone production by granulosa cells from preantral ovarian follicles: further in vitro studies using replicate cell cultures. Endocrinology 100(6):1539–1549CrossRefPubMed

Ismail MH, Stanslas ZP, Iman J,. Zhang MU, Ideris A, Mahmud R (2014) Edible Bird’s Nest Pretreatment Prevents Ovariectomy Induced Cognitive Aging in Morris Water Maze. Proceedings of the Edible Bird Nest Industry Conference, 25-26 November 2014, Putrajaya, Malaysia

Jomova K, Valko M (2011) Advances in metal-induced oxidative stress and human disease. Toxicology 283(2):65–87CrossRefPubMed

Juliani C, Silva-Zacarin E, Santos D, Boer P (2008) Effects of atrazine on female Wistar rats: morphological alterations in ovarian follicles and immunocytochemical labeling of 90kDa heat shock protein. Micron 39(5):607–616CrossRefPubMed

Kakuta H, Tanaka M, Chambon P, Watanabe H, Iguchi T, Sato T (2012) Involvement of gonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries in neonatally diethylstilbestrol-treated mice. Reprod Toxicol 33(1):35–44CrossRefPubMed

Kong Y, Tsao S, Song M, Ng M, Lin Z (1989) Potentiation of mitogenic response by extracts of the swiftlet’s (Apus) nest collected from Huai-ji. Acta Zool Sin 35(4):429–435

Lanzone A, Fortini A, Fulghesu AM, Soranna L, Caruso A, Mancuso S (1996) Growth hormone enhances estradiol production follicle-stimulating hormone-induced in the early stage of the follicular maturation. Fertil Steril 66(6):948–953.CrossRefPubMed

Luo L, Huang J, Fu Y, Xu J, Qian Y (2008) Effects of tea polyphenols on ovarian development in rats. J Endocrinol Investig 31(12):1110–1118CrossRef

Ma F, Liu D (2012a) Extraction and determination of hormones in the edible bird’s nest. Asian J Chem 24(1):117

Ma F, Liu D (2012b) Sketch of the edible bird’s nest and its important bioactivities. Food Res Int 48(2):559–567CrossRef

McLean AC, Valenzuela N, Fai S, Bennett SA (2012) Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification. J Vis Exp (67):4389

Ostrowska Z, Kos-Kudla B, Swietochowska E, Marek B, Kajdaniuk D, Ciesielska-Kopacz N (2001) Influence of pinealectomy and long-term melatonin administration on GH-IGF-I axis function in male rats. Neuroendocrinol Lett 22(4):255–262PubMed

Panzan MQ, Mattar R, Maganhin CC, dos Santos Simoes R, Rossi AGZ, da Motta ELA, Baracat EC, Soares-Jr JM (2013) Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss. Eur J Obstet Gynecol Reprod Biol 167(1):47–52CrossRefPubMed

Roh K-B, Lee J, Kim Y-S, Park J, Kim J-H, Lee J, Park D (2012) Mechanisms of edible bird’s nest extract-induced proliferation of human adipose-derived stem cells. Evid Based Complement Alternat Med 2012:1–11CrossRef

Romeu LRG, da Motta ELA, Maganhin CC, Oshima CT, Fonseca MC, Barrueco KF, Simoes RS, Pellegrino R, Baracat EC, Soares-Junior JM (2011) Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats. Fertil Steril 95(4):1379–1384CrossRefPubMed

Rzymski P, Tomczyk K, Poniedzialek B, Opala T, Wilczak M (2015) Impact of heavy metals on the female reproductive system. Ann Agric Environ Med 22(2):259–264CrossRefPubMed

Sharma R, Garu U, Panwar K (2012) Developing gonads and lead exposure. World J Environ Biosci 1:30–37

Spencer T, Bazer F (2004) Uterine and placental factors regulating conceptus growth in domestic animals. J Anim Sci 82(E. Suppl):E4–E13PubMed

Syarmila Etty IK, Nurfatin MH, Masitah M, Farahniza Z, Mohd. Khan A, Zalifah MK and Abdul Salam B (2014) Edible bird nest hydrolysates as natural antioxidative peptides (poster). Proceedings of the Edible Bird Nest Industry Conference, 25–26 November 2014, Putrajaya

Tamura H, Nakamura Y, Korkmaz A, Manchester LC, Tan D-X, Sugino N, Reiter RJ (2009) Melatonin and the ovary: physiological and pathophysiological implications. Fertil Steril 92(1):328–343CrossRefPubMed

Thavamanithevi S, Sarifah R, Lim CG, Theanmalar M, Aidawati MS, Durgah Devi M and Saleha AA (2014) Characterization and standardization of edible birds Nest (EBN)-determination of sialic acid. Proceedings of the Edible Bird Nest Industry Conference, 25-26 November 2014, Putrajaya

Utarabhand P, Rittidach W, Rattanaporn O, Runsaeng P, Hedrick JL (2017) Sialic acid-specific lectin participates in an immune response and ovarian development of the banana shrimp Fenneropenaeus merguiensis. Comp Biochem Physiol B: Biochem Mol Biol 203:132–140CrossRef

Wiebe JP, Barr KJ (1988) Effect of prenatal and neonatal exposure to lead on the affinity and number of estradiol receptors in the uterus. J Toxicol Environ Health A Curr Issues 24(4):451–460CrossRef

Yew MY, Koh RY, Chye SM, Othman I, Ng KY (2014) Edible bird’s nest ameliorates oxidative stress-induced apoptosis in SH-SY5Y human neuroblastoma cells. BMC Complement Altern Med 14(1):391CrossRefPubMedPubMedCentral

Yida Z, Imam MU, Ismail M, Hou Z, Abdullah MA, Ideris A, Ismail N (2015) Edible bird’s nest attenuates high fat diet-induced oxidative stress and inflammation via regulation of hepatic antioxidant and inflammatory genes. BMC Complement Altern Med 15(1):310CrossRefPubMedPubMedCentral

Żukowska-Arendarczyk M (1981) Effect of hypophyseal gonadotropins (FSH and LH) on the ovaries of the sand shrimp Crangon crangon (Crustacea: Decapoda). Mar Biol 63(3):241–247CrossRef

Title: Ameliorating effect of edible bird’s nest against lead acetate toxicity on the rat hypothalamic–pituitary–ovarian axis and expressions of epidermal growth factor and vascular endothelial growth factor in ovaries
Authors: Abdulla A. Albishtue
Nurhusien Yimer
Md Zuki A. Zakaria
Abd Wahid Haron
Rosnina Yusoff
Bahaa H. Almhanawi
Publication date: 01-09-2018
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 5/2018
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-018-2729-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ameliorating effect of edible bird’s nest against lead acetate toxicity on the rat hypothalamic–pituitary–ovarian axis and expressions of epidermal growth factor and vascular endothelial growth factor in ovaries

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2018

The first report of Nematode (Contracaecum) and two Acanthocephala (Serrasentis sagittifer, Tenuiosentis niloticus) in Persian Gulf’s Japanese threadfin bream (Nemipterus japonicus)

Nephroprotective activity of Alyssum meniocoides Boiss aqueous extract on streptozotocin-induced diabetic nephrotoxicity in male mice

Hematological, biochemical, serological, and molecular monitoring of blood donor dogs vaccinated with CaniLeish® for the prevention of Leishmaniosis

Effect of sex on haemocytobiochemical profiling of silver tiger fish (Datnioides polota Hamilton, 1822)

Effect of dexamethasone administration on the pathogenicity and lesion severity in rats experimentally inoculated with Orf virus (Malaysian isolates)

The survey of parasitic infections of wild pigeons (Columba livia) in Lahijan city, Guilan, Iran