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Acta Neuropathologica Communications
Published in: Acta Neuropathologica Communications 1/2024

Open Access 01-12-2024 | Alzheimer's Disease | Letter to the Editor

Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer’s disease

Authors: Lien Van Hoecke, Roosmarijn E. Vandenbroucke

Published in: Acta Neuropathologica Communications | Issue 1/2024

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Excerpt

The prevalence of Alzheimer’s disease (AD) continues to increase, with projections estimating 70 million patients by 2030. While recent FDA approvals for Aducanumab and Lecanemab have generated optimism, these therapies offer only partial relief by slowing cognitive decline [1‐2], leaving us ill-equipped to face the looming AD epidemic. To better address AD, we must enhance our understanding of its pathophysiology, with a focus on utilizing animal models that closely replicate the human condition. …
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Metadata
Title
Beyond genetics: including the environmental dimension in amyloidosis mouse models for Alzheimer’s disease
Authors
Lien Van Hoecke
Roosmarijn E. Vandenbroucke
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Acta Neuropathologica Communications / Issue 1/2024
Electronic ISSN: 2051-5960
DOI
https://doi.org/10.1186/s40478-024-01747-6

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