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01-11-2006 | Brief Report

Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury

Authors: Jean-Christophe Richard, Didier Le Bars, Nicolas Costes, Fabienne Bregeon, Christian Tourvieille, Franck Lavenne, Marc Janier, Gérard Gimenez, Claude Guerin

Published in: Intensive Care Medicine | Issue 11/2006

Abstract

Objectives

To compare changes in aerated lung volumes measured by positron emission tomography (PET) and inflation volume-pressure curve (V – P) of the respiratory system, and to evaluate the reliability of PET to assess alveolar recruitment.

Design and setting

Experimental study in six anesthetized and mechanically ventilated pigs in a PET facility in an experimental university laboratory.

Interventions

Lung injury was induced by oleic acid. Animals were randomly studied in four conditions: PEEP 0 cmH₂O (ZEEP) in supine position (SP), PEEP 10 cmH₂O in SP, ZEEP in prone position (PP) and PEEP in PP, each applied for 30 min.

Measurements and results

With PET aerated lung volume was obtained from pulmonary density analysis using transmission scan (VA_trans) and from nitrogen-13 kinetics on emission scan (VA_em). Changes in VA_trans and VA_em were computed as the difference in aerated volume between conditions. VA_trans and VA_em did not differ between SP and PP, on either ZEEP or PEEP, suggesting no modification in relaxation volume of the respiratory system induced by posture. Changes in VA_trans or VA_em were significantly correlated with changes in aerated volume assessed from superimposed V – P curves (R ² = 0.74 and 0.75, respectively). Alveolar recruitment assessed by PET was significantly correlated with both PaO₂ (R ² = 0.61) and PaCO₂ (R ² = 0.40) variations induced by PEEP.

Conclusions

PET is a new reliable tool of scientific interest to image lung volume and alveolar recruitment during acute lung injury.

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Title: Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury
Authors: Jean-Christophe Richard
Didier Le Bars
Nicolas Costes
Fabienne Bregeon
Christian Tourvieille
Franck Lavenne
Marc Janier
Gérard Gimenez
Claude Guerin
Publication date: 01-11-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 11/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0331-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Alveolar recruitment assessed by positron emission tomography during experimental acute lung injury

Abstract

Objectives

Design and setting

Interventions

Measurements and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Design and setting

Interventions

Measurements and results

Conclusions

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