Top

Published in:

01-07-2017 | Original Contribution

Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis

Authors: Qiong Wu, Xiaocui Zhang, Daifeng Dong, Xiang Wang, Shuqiao Yao

Published in: European Child & Adolescent Psychiatry | Issue 7/2017

Abstract

Functional magnetic resonance imaging (fMRI) studies have revealed abnormal neural activity in several brain regions of adolescents with conduct disorder (CD) performing various tasks. However, little is known about the spontaneous neural activity in people with CD in a resting state. The aims of this study were to investigate CD-associated regional activity abnormalities and to explore the relationship between behavioral impulsivity and regional activity abnormalities. Resting-state fMRI (rs-fMRI) scans were administered to 28 adolescents with CD and 28 age-, gender-, and IQ-matched healthy controls (HCs). The rs-fMRI data were subjected to regional homogeneity (ReHo) analysis. ReHo can demonstrate the temporal synchrony of regional blood oxygen level-dependent signals and reflect the coordination of local neuronal activity facilitating similar goals or representations. Compared to HCs, the CD group showed increased ReHo bilaterally in the insula as well as decreased ReHo in the right inferior parietal lobule, right middle temporal gyrus and right fusiform gyrus, left anterior cerebellum anterior, and right posterior cerebellum. In the CD group, mean ReHo values in the left and the right insula correlated positively with Barratt Impulsivity Scale (BIS) total scores. The results suggest that CD is associated with abnormal intrinsic brain activity, mainly in the cerebellum and temporal–parietal-limbic cortices, regions that are related to emotional and cognitive processing. BIS scores in adolescents with CD may reflect severity of abnormal neuronal synchronization in the insula.

Available only for authorised users

Association AP (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR, 4th edn. American Psychiatric Association, Washington

Olsson M (2009) DSM diagnosis of conduct disorder (CD)—a review. Nord J Psychiatry 63(2):102–112. doi:10.1080/08039480802626939 PubMedCrossRef

Loeber R, Burke JD, Lahey BB, Winters A, Zera M (2000) Oppositional defiant and conduct disorder: a review of the past 10 years, part I. J Am Acad Child Adolesc Psychiatry 39(12):1468–1484. doi:10.1097/00004583-200012000-00007 PubMedCrossRef

Marmorstein NR, Iacono WG (2003) Major depression and conduct disorder in a twin sample: gender, functioning, and risk for future psychopathology. J Am Acad Child Adolesc Psychiatry 42(2):225–233. doi:10.1097/00004583-200302000-00017 PubMedCrossRef

Disney ER, Elkins IJ, McGue M, Iacono WG (1999) Effects of ADHD, conduct disorder, and gender on substance use and abuse in adolescence. Am J Psychiatry 156(10):1515–1521PubMedCrossRef

Dixon A, Howie P, Starling J (2005) Trauma exposure, posttraumatic stress, and psychiatric comorbidity in female juvenile offenders. J Am Acad Child Adolesc Psychiatry 44(8):798–806. doi:10.1097/01.chi.0000164590.48318.9c PubMedCrossRef

Hare RD, Hart SD, Harpur TJ (1991) Psychopathy and the DSM-IV criteria for antisocial personality disorder. J Abnorm Psychol 100(3):391–398PubMedCrossRef

Burke JD, Loeber R, Birmaher B (2002) Oppositional defiant disorder and conduct disorder: a review of the past 10 years, part II. J Am Acad Child Adolesc Psychiatry 41(11):1275–1293. doi:10.1097/00004583-200211000-00009 PubMedCrossRef

Blair RJ (2013) The neurobiology of psychopathic traits in youths. Nat Rev Neurosci 14(11):786–799. doi:10.1038/nrn3577 PubMedPubMedCentralCrossRef

10.

Byrd AL, Loeber R, Pardini DA (2014) Antisocial behavior, psychopathic features and abnormalities in reward and punishment processing in youth. Clin Child Fam Psychol Rev 17(2):125–156. doi:10.1007/s10567-013-0159-6 PubMedPubMedCentralCrossRef

11.

Huebner T, Vloet TD, Marx I, Konrad K, Fink GR, Herpertz SC, Herpertz-Dahlmann B (2008) Morphometric brain abnormalities in boys with conduct disorder. J Am Acad Child Adolesc Psychiatry 47(5):540–547. doi:10.1097/CHI.0b013e3181676545 PubMedCrossRef

12.

Hyatt CJ, Haney-Caron E, Stevens MC (2012) Cortical thickness and folding deficits in conduct-disordered adolescents. Biol Psychiatry 72(3):207–214. doi:10.1016/j.biopsych.2011.11.017 PubMedCrossRef

13.

Sterzer P, Stadler C, Poustka F, Kleinschmidt A (2007) A structural neural deficit in adolescents with conduct disorder and its association with lack of empathy. NeuroImage 37(1):335–342. doi:10.1016/j.neuroimage.2007.04.043 PubMedCrossRef

14.

Kruesi MJ, Casanova MF, Mannheim G, Johnson-Bilder A (2004) Reduced temporal lobe volume in early onset conduct disorder. Psychiatry Res 132(1):1–11. doi:10.1016/j.pscychresns.2004.07.002 PubMedCrossRef

15.

De Brito SA, Mechelli A, Wilke M, Laurens KR, Jones AP, Barker GJ, Hodgins S, Viding E (2009) Size matters: increased grey matter in boys with conduct problems and callous-unemotional traits. Brain 132(Pt 4):843–852. doi:10.1093/brain/awp011 PubMedCrossRef

16.

Zhang J, Zhu X, Wang X, Gao J, Shi H, Huang B, Situ W, Yi J, Zhu X, Yao S (2014) Increased structural connectivity in corpus callosum in adolescent males with conduct disorder. J Am Acad Child Adolesc Psychiatry 53(4):466–475. doi:10.1016/j.jaac.2013.12.015 PubMedCrossRef

17.

Haney-Caron E, Caprihan A, Stevens MC (2014) DTI-measured white matter abnormalities in adolescents with Conduct Disorder. J Psychiatr Res 48(1):111–120. doi:10.1016/j.jpsychires.2013.09.015 PubMedCrossRef

18.

Gatzke-Kopp LM, Beauchaine TP, Shannon KE, Chipman J, Fleming AP, Crowell SE, Liang O, Johnson LC, Aylward E (2009) Neurological correlates of reward responding in adolescents with and without externalizing behavior disorders. J Abnorm Psychol 118(1):203–213. doi:10.1037/a0014378 PubMedPubMedCentralCrossRef

19.

Rubia K, Smith AB, Halari R, Matsukura F, Mohammad M, Taylor E, Brammer MJ (2009) Disorder-specific dissociation of orbitofrontal dysfunction in boys with pure conduct disorder during reward and ventrolateral prefrontal dysfunction in boys with pure ADHD during sustained attention. Am J Psychiatry 166(1):83–94. doi:10.1176/appi.ajp.2008.08020212 PubMedCrossRef

20.

Sterzer P, Stadler C, Krebs A, Kleinschmidt A, Poustka F (2005) Abnormal neural responses to emotional visual stimuli in adolescents with conduct disorder. Biol Psychiatry 57(1):7–15. doi:10.1016/j.biopsych.2004.10.008 PubMedCrossRef

21.

Decety J, Michalska KJ, Akitsuki Y, Lahey BB (2009) Atypical empathic responses in adolescents with aggressive conduct disorder: a functional MRI investigation. Biol Psychol 80(2):203–211. doi:10.1016/j.biopsycho.2008.09.004 PubMedCrossRef

22.

Lockwood PL, Sebastian CL, McCrory EJ, Hyde ZH, Gu X, De Brito SA, Viding E (2013) Association of callous traits with reduced neural response to others’ pain in children with conduct problems. Curr Biol 23(10):901–905. doi:10.1016/j.cub.2013.04.018 PubMedPubMedCentralCrossRef

23.

Marsh AA, Finger EC, Mitchell DG, Reid ME, Sims C, Kosson DS, Towbin KE, Leibenluft E, Pine DS, Blair RJ (2008) Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. Am J Psychiatry 165(6):712–720. doi:10.1176/appi.ajp.2007.07071145 PubMedCrossRef

24.

Herpertz SC, Huebner T, Marx I, Vloet TD, Fink GR, Stoecker T, Shah NJ, Konrad K, Herpertz-Dahlmann B (2008) Emotional processing in male adolescents with childhood-onset conduct disorder. J Child Psychol Psychiatry 49(7):781–791. doi:10.1111/j.1469-7610.2008.01905.x PubMedCrossRef

25.

Passamonti L, Fairchild G, Goodyer IM, Hurford G, Hagan CC, Rowe JB, Calder AJ (2010) Neural abnormalities in early-onset and adolescence-onset conduct disorder. Arch Gen Psychiatry 67(7):729–738. doi:10.1001/archgenpsychiatry.2010.75 PubMedPubMedCentralCrossRef

26.

Fairchild G, Hagan CC, Passamonti L, Walsh ND, Goodyer IM, Calder AJ (2014) Atypical neural responses during face processing in female adolescents with conduct disorder. J Am Acad Child Adolesct Psychiatry 53(6):677–687. doi:10.1016/j.jaac.2014.02.009 CrossRef

27.

Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8(9):700–711. doi:10.1038/nrn2201 PubMedCrossRef

28.

Zang YF, He Y, Zhu CZ, Cao QJ, Sui MQ, Liang M, Tian LX, Jiang TZ, Wang YF (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 29(2):83–91. doi:10.1016/j.braindev.2006.07.002 PubMedCrossRef

29.

Zhou J, Yao N, Fairchild G, Zhang Y, Wang X (2015) Altered hemodynamic activity in conduct disorder: a resting-state FMRI investigation. PLoS One 10(3):e0122750. doi:10.1371/journal.pone.0122750 PubMedPubMedCentralCrossRef

30.

Zhou J, Yao N, Fairchild G, Cao X, Zhang Y, Xiang YT, Zhang L, Wang X (2015) Disrupted default mode network connectivity in male adolescents with conduct disorder. Brain Imaging Behav. doi:10.1007/s11682-015-9465-6

31.

Lu FM, Zhou JS, Zhang J, Xiang YT, Zhang J, Liu Q, Wang XP, Yuan Z (2015) Functional connectivity estimated from resting-state fMRI reveals selective alterations in male adolescents with pure conduct disorder. PLoS One 10(12):e0145668. doi:10.1371/journal.pone.0145668 PubMedPubMedCentralCrossRef

32.

Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL (2001) A default mode of brain function. Proc Natl Acad Sci USA 98(2):676–682. doi:10.1073/pnas.98.2.676 PubMedPubMedCentralCrossRef

33.

Andrews-Hanna JR (2012) The brain’s default network and its adaptive role in internal mentation. Neuroscientist 18(3):251–270. doi:10.1177/1073858411403316 PubMedCrossRef

34.

Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37(1):51–87PubMedCrossRef

35.

Diamond A (2013) Executive functions. Annu Rev Psychol 64:135–168. doi:10.1146/annurev-psych-113011-143750 PubMedCrossRef

36.

Prencipe A, Kesek A, Cohen J, Lamm C, Lewis MD, Zelazo PD (2011) Development of hot and cool executive function during the transition to adolescence. J Exp Child Psychol 108(3):621–637. doi:10.1016/j.jecp.2010.09.008 PubMedCrossRef

37.

Rubia K (2011) “Cool” inferior frontostriatal dysfunction in attention-deficit/hyperactivity disorder versus “hot” ventromedial orbitofrontal-limbic dysfunction in conduct disorder: a review. Biol Psychiatry 69(12):e69–e87. doi:10.1016/j.biopsych.2010.09.023 PubMedCrossRef

38.

Yang Y, Raine A (2009) Prefrontal structural and functional brain imaging findings in antisocial, violent, and psychopathic individuals: a meta-analysis. Psychiatry Res 174(2):81–88. doi:10.1016/j.pscychresns.2009.03.012 PubMedPubMedCentralCrossRef

39.

Blair RJR (2005) Applying a cognitive neuroscience perspective to the disorder of psychopathy. Dev Psychopathol 17(3):865–891PubMedCrossRef

40.

Noordermeer SD, Luman M, Oosterlaan J (2016) A systematic review and meta-analysis of neuroimaging in oppositional defiant disorder (ODD) and conduct disorder (CD) taking attention-deficit hyperactivity disorder (ADHD) into account. Neuropsychol Rev 26(1):44–72. doi:10.1007/s11065-015-9315-8 PubMedPubMedCentralCrossRef

41.

Zang Y, Jiang T, Lu Y, He Y, Tian L (2004) Regional homogeneity approach to fMRI data analysis. NeuroImage 22(1):394–400. doi:10.1016/j.neuroimage.2003.12.030 PubMedCrossRef

42.

Liu H, Liu Z, Liang M, Hao Y, Tan L, Kuang F, Yi Y, Xu L, Jiang T (2006) Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. NeuroReport 17(1):19–22PubMedCrossRef

43.

Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BTT, Buckner RL (2010) The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol 6(6):e1000808PubMedPubMedCentralCrossRef

44.

Jiang L, Zuo XN (2015) Regional homogeneity: a multimodal, multiscale neuroimaging marker of the human connectome. Neuroscientist. doi:10.1177/1073858415595004 PubMedPubMedCentral

45.

Jiang L, Xu T, He Y, Hou XH, Wang J, Cao XY, Wei GX, Yang Z, He Y, Zuo XN (2015) Toward neurobiological characterization of functional homogeneity in the human cortex: regional variation, morphological association and functional covariance network organization. Brain Struct Func 220(5):2485–2507. doi:10.1007/s00429-014-0795-8 CrossRef

46.

An L, Cao QJ, Sui MQ, Sun L, Zou QH, Zang YF, Wang YF (2013) Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study. Neurosci Bull 29(5):603–613. doi:10.1007/s12264-013-1353-8 PubMedCrossRef

47.

Huang T, Zhao Z, Yan C, Lu J, Li X, Tang C, Fan M, Luo Y (2016) Altered spontaneous activity in patients with persistent somatoform pain disorder revealed by regional homogeneity. PLoS One 11(3):e0151360. doi:10.1371/journal.pone.0151360 PubMedPubMedCentralCrossRef

48.

Zuo XN, Xu T, Jiang L, Yang Z, Cao XY, He Y, Zang YF, Castellanos FX, Milham MP (2013) Toward reliable characterization of functional homogeneity in the human brain: preprocessing, scan duration, imaging resolution and computational space. NeuroImage 65:374–386. doi:10.1016/j.neuroimage.2012.10.017 PubMedCrossRef

49.

Yuan Y, Zhang Z, Bai F, Yu H, Shi Y, Qian Y, Liu W, You J, Zhang X, Liu Z (2008) Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study. J Affect Disord 111(2–3):145–152. doi:10.1016/j.jad.2008.02.016 PubMedCrossRef

50.

Yao Z, Wang L, Lu Q, Liu H, Teng G (2009) Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study. J Affect Disord 115(3):430–438. doi:10.1016/j.jad.2008.10.013 PubMedCrossRef

51.

Lai CH, Wu YT (2015) The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-naive depression patients. Brain Imaging Behav. doi:10.1007/s11682-015-9381-9

52.

Paakki JJ, Rahko J, Long X, Moilanen I, Tervonen O, Nikkinen J, Starck T, Remes J, Hurtig T, Haapsamo H, Jussila K, Kuusikko-Gauffin S, Mattila ML, Zang Y, Kiviniemi V (2010) Alterations in regional homogeneity of resting-state brain activity in autism spectrum disorders. Brain Res 1321:169–179. doi:10.1016/j.brainres.2009.12.081 PubMedCrossRef

53.

Li H, Lu Q, Xiao E, Li Q, He Z, Mei X (2014) Methamphetamine enhances the development of schizophrenia in first-degree relatives of patients with schizophrenia. Can J Psychiatry 59(2):107–113PubMedPubMedCentral

54.

Yang XY, Sun J, Luo J, Zhong ZX, Li P, Yao SM, Xiong HF, Huang FF, Li ZJ (2015) Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy. J Affect Disord 188:243–251. doi:10.1016/j.jad.2015.07.048 PubMedCrossRef

55.

Cao Q, Zang Y, Sun L, Sui M, Long X, Zou Q, Wang Y (2006) Abnormal neural activity in children with attention deficit hyperactivity disorder: a resting-state functional magnetic resonance imaging study. Neuroreport 17(10):1033–1036. doi:10.1097/01.wnr.0000224769.92454.5d PubMedCrossRef

56.

First M, Spitzer R, Gibbon M, Williams J (2002) Structured clinical interview for DSM-IV-TR axis I disorders–patient edtion (SCID-I/P, 11/2002 revision). New York State Psychiatric Institute, New York

57.

Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9(1):97–113PubMedCrossRef

58.

Gong Y, Cai T (1993) Wechsler intelligence scale for children, Chinese revision (C-WISC). Map Press Hunan, China

59.

Radloff LS (1977) The CES-D scale a self-report depression scale for research in the general population. Appl Psychol Meas 1(3):385–401CrossRef

60.

Yao S, Zou T, Zhu X, Abela JR, Auerbach RP, Tong X (2007) Reliability and validity of the Chinese version of the multidimensional anxiety scale for children among Chinese secondary school students. Child Psychiatry Hum Dev 38(1):1–16. doi:10.1007/s10578-006-0039-0 PubMedCrossRef

61.

Hu M, Wang M, Cai L, Zhu X, Yao S (2012) Development of subjective socioeconomic status scale for Chinese adolescents. Chin J Clin Psychol 20(2):155–161

62.

Yao S, Yang H, Zhu X, Auerbach RP, Abela JR, Pulleyblank RW, Tong X (2007) An examination of the psychometric properties of the Chinese version of the Barratt Impulsiveness Scale, 11th version in a sample of Chinese adolescents. Percept Mot Skills 104(3 Pt 2):1169–1182. doi:10.2466/pms.104.4.1169-1182 PubMed

63.

Chao-Gan Y, Yu-Feng Z (2010) DPARSF: a MATLAB toolbox for “Pipeline” data analysis of resting-state fMRI. Frontiers in systems neuroscience 4:13. doi:10.3389/fnsys.2010.00013 PubMedPubMedCentral

64.

Lai C-H, Wu Y-T (2016) The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-naive depression patients. Brain Imaging Behav 10(1):187–194PubMedCrossRef

65.

Xue S, Wang X, Wang W, Liu J, Qiu J (2016) Frequency-dependent alterations in regional homogeneity in major depression. Behav Brain Res 306:13–19PubMedCrossRef

66.

Michalska KJ, Zeffiro TA, Decety J (2016) Brain response to viewing others being harmed in children with conduct disorder symptoms. J Child Psychol Psychiatry 57(4):510–519PubMedCrossRef

67.

Zhu Y, Ying K, Wang J, Su L, Chen J, Lin F, Cai D, Zhou M, Wu D, Guo C, Wang S (2014) Differences in functional activity between boys with pure oppositional defiant disorder and controls during a response inhibition task: a preliminary study. Brain Imaging Behav 8(4):588–597PubMedCrossRef

68.

Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012) Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. NeuroImage 59(3):2142–2154. doi:10.1016/j.neuroimage.2011.10.018 PubMedCrossRef

69.

Satterthwaite TD, Elliott MA, Gerraty RT, Ruparel K, Loughead J, Calkins ME, Eickhoff SB, Hakonarson H, Gur RC, Gur RE, Wolf DH (2013) An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data. NeuroImage 64:240–256. doi:10.1016/j.neuroimage.2012.08.052 PubMedCrossRef

70.

Friston KJ, Williams S, Howard R, Frackowiak RS, Turner R (1996) Movement-related effects in fMRI time-series. Magn Reson Med 35(3):346–355PubMedCrossRef

71.

Yan CG, Cheung B, Kelly C, Colcombe S, Craddock RC, Di Martino A, Li Q, Zuo XN, Castellanos FX, Milham MP (2013) A comprehensive assessment of regional variation in the impact of head micromovements on functional connectomics. NeuroImage 76:183–201. doi:10.1016/j.neuroimage.2013.03.004 PubMedPubMedCentralCrossRef

72.

Song XW, Dong ZY, Long XY, Li SF, Zuo XN, Zhu CZ, He Y, Yan CG, Zang YF (2011) REST: a toolkit for resting-state functional magnetic resonance imaging data processing. PLoS One 6(9):e25031. doi:10.1371/journal.pone.0025031 PubMedPubMedCentralCrossRef

73.

Nichols T, Hayasaka S (2003) Controlling the familywise error rate in functional neuroimaging: a comparative review. Stat Methods Med Res 12(5):419–446PubMedCrossRef

74.

Long XY, Zuo XN, Kiviniemi V, Yang Y, Zou QH, Zhu CZ, Jiang TZ, Yang H, Gong QY, Wang L, Li KC, Xie S, Zang YF (2008) Default mode network as revealed with multiple methods for resting-state functional MRI analysis. J Neurosci Methods 171(2):349–355. doi:10.1016/j.jneumeth.2008.03.021 PubMedCrossRef

75.

Wu T, Long X, Zang Y, Wang L, Hallett M, Li K, Chan P (2009) Regional homogeneity changes in patients with Parkinson’s disease. Hum Brain Mapp 30(5):1502–1510. doi:10.1002/hbm.20622 PubMedCrossRef

76.

Davidson RJ, Irwin W (1999) The functional neuroanatomy of emotion and affective style. Trends Cognitive Sci 3(1):11–21CrossRef

77.

Zaki J, Weber J, Ochsner K (2012) Task-dependent neural bases of perceiving emotionally expressive targets. Frontiers in human neuroscience 6:228. doi:10.3389/fnhum.2012.00228 PubMedPubMedCentralCrossRef

78.

Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303(5661):1157–1162. doi:10.1126/science.1093535 PubMedCrossRef

79.

Gorno-Tempini ML, Pradelli S, Serafini M, Pagnoni G, Baraldi P, Porro C, Nicoletti R, Umita C, Nichelli P (2001) Explicit and incidental facial expression processing: an fMRI study. NeuroImage 14(2):465–473. doi:10.1006/nimg.2001.0811 PubMedCrossRef

80.

Sebastian CL, McCrory EJ, Cecil CA, Lockwood PL, De Brito SA, Fontaine NM, Viding E (2012) Neural responses to affective and cognitive theory of mind in children with conduct problems and varying levels of callous-unemotional traits. Arch Gen Psychiatry 69(8):814–822. doi:10.1001/archgenpsychiatry.2011.2070 PubMedCrossRef

81.

Liu C, Xue Z, Palaniyappan L, Zhou L, Liu H, Qi C, Wu G, Mwansisya TE, Tao H, Chen X, Huang X, Liu Z, Pu W (2016) Abnormally increased and incoherent resting-state activity is shared between patients with schizophrenia and their unaffected siblings. Schizophr Res 171(1–3):158–165. doi:10.1016/j.schres.2016.01.022 PubMedCrossRef

82.

Lee TM, Chan CC, Han SH, Leung AW, Fox PT, Gao JH (2008) An event-related fMRI study on risk taking by healthy individuals of high or low impulsiveness. Neurosci Lett 438(2):138–141. doi:10.1016/j.neulet.2008.04.061 PubMedCrossRef

83.

van Elst LT, Woermann FG, Lemieux L, Thompson PJ, Trimble MR (2000) Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala. Brain 123(Pt 2):234–243PubMedCrossRef

84.

Perry RJ, Rosen HR, Kramer JH, Beer JS, Levenson RL, Miller BL (2001) Hemispheric dominance for emotions, empathy and social behaviour: evidence from right and left handers with frontotemporal dementia. Neurocase 7(2):145–160. doi:10.1093/neucas/7.2.145 PubMedCrossRef

85.

Schultz RT (2005) Developmental deficits in social perception in autism: the role of the amygdala and fusiform face area. Int J Dev Neurosci 23(2–3):125–141. doi:10.1016/j.ijdevneu.2004.12.012 PubMedCrossRef

86.

Winston JS, Henson RN, Fine-Goulden MR, Dolan RJ (2004) fMRI-adaptation reveals dissociable neural representations of identity and expression in face perception. J Neurophysiol 92(3):1830–1839. doi:10.1152/jn.00155.2004 PubMedCrossRef

87.

Fairchild G, Van Goozen SH, Calder AJ, Stollery SJ, Goodyer IM (2009) Deficits in facial expression recognition in male adolescents with early onset or adolescence-onset conduct disorder. J Child Psychol Psychiatry 50(5):627–636. doi:10.1111/j.1469-7610.2008.02020.x PubMedPubMedCentralCrossRef

88.

Gallese V, Keysers C, Rizzolatti G (2004) A unifying view of the basis of social cognition. Trends Cognitive Sci 8(9):396–403. doi:10.1016/j.tics.2004.07.002 CrossRef

89.

Ramsey R, Cross ES, Hamilton AF (2012) Predicting others’ actions via grasp and gaze: evidence for distinct brain networks. Psychol Res 76(4):494–502. doi:10.1007/s00426-011-0393-9 PubMedCrossRef

90.

Mende-Siedlecki P, Cai Y, Todorov A (2013) The neural dynamics of updating person impressions. Social cognitive and affective neuroscience 8(6):623–631. doi:10.1093/scan/nss040 PubMedCrossRef

91.

Tamura M, Moriguchi Y, Higuchi S, Hida A, Enomoto M, Umezawa J, Mishima K (2012) Neural network development in late adolescents during observation of risk-taking action. PLoS One 7(6):e39527. doi:10.1371/journal.pone.0039527 PubMedPubMedCentralCrossRef

92.

Rubia K, Halari R, Smith AB, Mohammed M, Scott S, Giampietro V, Taylor E, Brammer MJ (2008) Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. Am J Psychiatry 165(7):889–897. doi:10.1176/appi.ajp.2008.07071084 PubMedCrossRef

93.

Bastian AJ (2006) Learning to predict the future: the cerebellum adapts feedforward movement control. Curr Opin Neurobiol 16(6):645–649. doi:10.1016/j.conb.2006.08.016 PubMedCrossRef

94.

Schmahmann JD (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 16(3):367–378. doi:10.1176/jnp.16.3.367 PubMedCrossRef

95.

Schmahmann JD, Caplan D (2006) Cognition, emotion and the cerebellum. Brain 129(Pt 2):290–292. doi:10.1093/brain/awh729 PubMed

96.

Gordon N (2007) The cerebellum and cognition. Eur J Paediatr Neurol 11(4):232–234. doi:10.1016/j.ejpn.2007.02.003 PubMedCrossRef

97.

Annoni JM, Ptak R, Caldara-Schnetzer AS, Khateb A, Pollermann BZ (2003) Decoupling of autonomic and cognitive emotional reactions after cerebellar stroke. Ann Neurol 53(5):654–658. doi:10.1002/ana.10549 PubMedCrossRef

Title: Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis
Authors: Qiong Wu
Xiaocui Zhang
Daifeng Dong
Xiang Wang
Shuqiao Yao
Publication date: 01-07-2017
Publisher: Springer Berlin Heidelberg
Published in: European Child & Adolescent Psychiatry / Issue 7/2017
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-017-0953-7

At a glance: The STEP trials

Springer Medicine

Altered spontaneous brain activity in adolescent boys with pure conduct disorder revealed by regional homogeneity analysis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 7/2017

Bullying involvement in relation to personality disorders: a prospective follow-up of 508 inpatient adolescents

Are assisted reproduction technologies associated with categorical or dimensional aspects of psychopathology in childhood, adolescence or early adulthood? Results from a Danish prospective nationwide cohort study

Predictive validity of parent- and self-rated ADHD symptoms in adolescence on adverse socioeconomic and health outcomes

Should we change targets and methods of early intervention in autism, in favor of a strengths-based education?

Children with social anxiety and other anxiety disorders show similar deficits in habitual emotional regulation: evidence for a transdiagnostic phenomenon

Influence of exposure to perinatal risk factors and parental mental health related hospital admission on adolescent deliberate self-harm risk