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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2016 | Research article

Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study

Authors: Zhiye Chen, Xiaoyan Chen, Mengqi Liu, Shuangfeng Liu, Siyun Shu, Lin Ma, Shengyuan Yu

Published in: The Journal of Headache and Pain | Issue 1/2015

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Abstract

Background

The marginal division of neostriatum (MrD) is a flat, pan-shaped zone between the neostriatum and the globus pallidus, and previous documents demonstrated that it was involved in the modulation of pain. The aim of this study is to investigate the roles of the MrD of the human brain in the chronicization migraine using resting state functional magnetic resonance imaging (rs-fMRI).

Methods

Conventional MRI, 3D structure images, and rs-fMRI were performed in 18 patients with episodic migraines (EM), 16 patients with chronic migraine (CM), 44 patients with medication overuse headache plus chronic migraine (MOH + CM), and 32 normal controls (NC). MrD was defined using manual delineation on structural images, and was selected as the seed to calculate the functional connectivity (FC).

Results

Compared with the NC group, the decreased FC of MrD was observed in the EM and CM groups, and increased FC of MrD was demonstrated in all patient groups. Compared with the EM group, the decreased FC of MrD was revealed in the CM and MOH + CM groups, and the increased FC occurred only in the CM group. Increased FC of MrD alone was observed in the MOH + CM group compared with that in the CM group.

Conclusion

This study confirmed the double neuromodulation network of MrD in pain modulation and migraine chronicization; however, the mechanism requires further investigation.
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Metadata
Title
Altered functional connectivity of the marginal division in migraine: a resting-state fMRI study
Authors
Zhiye Chen
Xiaoyan Chen
Mengqi Liu
Shuangfeng Liu
Siyun Shu
Lin Ma
Shengyuan Yu
Publication date
01-12-2016
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-016-0682-1

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