Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Journal of Experimental & Clinical Cancer Research
Published in: Journal of Experimental & Clinical Cancer Research 1/2010

Open Access 01-12-2010 | Research

Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma

Authors: Feng Ye, Yan Yu, Yuting Hu, Weiguo Lu, Xing Xie

Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2010

Login to get access

Abstract

Patients with cervical carcinoma (CC) are frequently immunocompromised. Dendritic cells (DCs) are potent antigen-presenting cells. Using multicolor flow cytometry, the percentages of CD11c+ (DC1) and CD123+ (DC2) subsets, were determined in the peripheral blood of 37 patients with cervical carcinoma (CC), 54 patients with CIN, and 62 healthy individuals. A substantial reduction of circulating dendritic cells and accordingly immunodepression may be associated with increased IL-6 and TGF-β in serum. These findings could give expression to the immunosuppression of circulating dendritic cells in patients with CC and CIN, thus, may indicate novel aspects of cervical carcinoma immune evasion.
Appendix
Available only for authorised users
Literature
1.
Pisani P, Parkin DM, Bray F, Ferlay J: Estimates of the worldwide mortality from 25 cancers in 1990. International journal of cancer. 1999, 83: 18-29. 10.1002/(SICI)1097-0215(19990924)83:1<18::AID-IJC5>3.0.CO;2-M.CrossRef
2.
Castle PE, Sideri M, Jeronimo J, Solomon D, Schiffman M: Risk assessment to guide the prevention of cervical cancer. American journal of obstetrics and gynecology. 2007, 197 (356): e1-6.
3.
Bosch FX, Lorincz A, Munoz N, Meijer CJ, Shah KV: The causal relation between human papillomavirus and cervical cancer. Journal of clinical pathology. 2002, 244: 65-
4.
Pekarek LA, Starr BA, Toledano AY, Schreiber H: Inhibition of tumor growth by elimination of granulocytes. The Journal of experimental medicine. 1995, 181 (435): 40-
5.
Steller MA: Cervical cancer vaccines: progress and prospects. Journal of the Society for Gynecologic Investigation. 2002, 9: 254-64. 10.1016/S1071-5576(02)00166-1.CrossRef
6.
Muderspach L, Wilczynski S, Roman L, et al: A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin Cancer Res. 2000, 6: 3406-16.
7.
Landoni F, Maneo A, Colombo A, et al: Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 1997, 350: 535-40. 10.1016/S0140-6736(97)02250-2.CrossRef
8.
Long HJ: Management of metastatic cervical cancer: review of the literature. J Clin Oncol. 2007, 25: 2966-74. 10.1200/JCO.2006.09.3781.CrossRef
9.
Stoler MH, Rhodes CR, Whitbeck A, Wolinsky SM, Chow LT, Broker TR: Human papillomavirus type 16 and 18 gene expression in cervical neoplasias. Human pathology. 1992, 23: 117-28. 10.1016/0046-8177(92)90232-R.CrossRef
10.
Honma S, Tsukada S, Honda S, et al: Biological-clinical significance of selective loss of HLA-class-I allelic product expression in squamous-cell carcinoma of the uterine cervix. International journal of cancer. 1994, 57: 650-5. 10.1002/ijc.2910570507.CrossRef
11.
Nickoloff BJ, Turka LA: Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunology today. 1994, 15: 464-9. 10.1016/0167-5699(94)90190-2.CrossRef
12.
Steinman RM: The dendritic cell system and its role in immunogenicity. Annual review of immunology. 1991, 9: 271-96. 10.1146/annurev.iy.09.040191.001415.CrossRef
13.
Adams M, Navabi H, Jasani B, et al: Dendritic cell (DC) based therapy for cervical cancer: use of DC pulsed with tumour lysate and matured with a novel synthetic clinically non-toxic double stranded RNA analogue poly [I]:poly [C(12)U] (Ampligen R). Vaccine. 2003, 21: 787-90. 10.1016/S0264-410X(02)00599-6.CrossRef
14.
Santin AD, Bellone S, Roman JJ, Burnett A, Cannon MJ, Pecorelli S: Therapeutic vaccines for cervical cancer: dendritic cell-based immunotherapy. Current pharmaceutical design. 2005, 11: 3485-500. 10.2174/138161205774414565.CrossRef
15.
Liu Y, Chiriva-Internati M, Grizzi F, et al: Rapid induction of cytotoxic T-cell response against cervical cancer cells by human papillomavirus type 16 E6 antigen gene delivery into human dendritic cells by an adeno-associated virus vector. Cancer gene therapy. 2001, 8: 948-57. 10.1038/sj.cgt.7700391.CrossRef
16.
Santin AD, Bellone S, Palmieri M, et al: HPV16/18 E7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalities. Gynecologic oncology. 2006, 100: 469-78. 10.1016/j.ygyno.2005.09.040.CrossRef
17.
Ferrara A, Nonn M, Sehr P, et al: Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 individual patients. Journal of cancer research and clinical oncology. 2003, 129: 521-30. 10.1007/s00432-003-0463-5.CrossRef
18.
Dubsky P, Ueno H, Piqueras B, Connolly J, Banchereau J, Palucka AK: Human dendritic cell subsets for vaccination. Journal of clinical immunology. 2005, 25: 551-72. 10.1007/s10875-005-8216-7.CrossRef
19.
Chen M, Huang L, Shabier Z, Wang J: Regulation of the lifespan in dendritic cell subsets. Molecular immunology. 2007, 44: 2558-65. 10.1016/j.molimm.2006.12.020.CrossRef
20.
Dudziak D, Kamphorst AO, Heidkamp GF, et al: Differential antigen processing by dendritic cell subsets in vivo. Science (New York, NY). 2007, 315: 107-11.CrossRef
21.
Colonna M, Trinchieri G, Liu YJ: Plasmacytoid dendritic cells in immunity. Nature immunology. 2004, 5: 1219-26. 10.1038/ni1141.CrossRef
22.
Kadowaki N, Ho S, Antonenko S, et al: Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. The Journal of experimental medicine. 2001, 194: 863-9. 10.1084/jem.194.6.863.CrossRef
23.
Wojas K, Tabarkiewicz J, Jankiewicz M, Rolinski J: Dendritic cells in peripheral blood of patients with breast and lung cancer--a pilot study. Folia histochemica et cytobiologica/Polish Academy of Sciences, Polish Histochemical and Cytochemical Society. 2004, 42: 45-8.
24.
Ferrari S, Malugani F, Rovati B, Porta C, Riccardi A, Danova M: Flow cytometric analysis of circulating dendritic cell subsets and intracellular cytokine production in advanced breast cancer patients. Oncology reports. 2005, 14: 113-20.
25.
Maecker B, Mougiakakos D, Zimmermann M, et al: Dendritic cell deficiencies in pediatric acute lymphoblastic leukemia patients. Leukemia. 2006, 20: 645-9. 10.1038/sj.leu.2404146.CrossRef
26.
Dickson J, Davidson SE, Hunter RD, West CM: Pretreatment plasma TGF beta 1 levels are prognostic for survival but not morbidity following radiation therapy of carcinoma of the cervix. International journal of radiation oncology, biology, physics. 2000, 48: 991-5. 10.1016/S0360-3016(00)00729-X.CrossRef
27.
Ratta M, Fagnoni F, Curti A, et al: Dendritic cells are functionally defective in multiple myeloma the role of interleukin-6. Blood. 2002, 100: 230-7. 10.1182/blood.V100.1.230.CrossRef
28.
Walsh SV, Hopkins AM, Nusrat A: Modulation of tight junction structure and function by cytokines. Advanced drug delivery reviews. 2000, 41: 303-13. 10.1016/S0169-409X(00)00048-X.CrossRef
29.
Beckebaum S, Zhang X, Chen X, et al: Increased levels of interleukin-10 in serum from patients with hepatocellular carcinoma correlate with profound numerical deficiencies and immature phenotype of circulating dendritic cell subsets. Clin Cancer Res. 2004, 10: 7260-9. 10.1158/1078-0432.CCR-04-0872.CrossRef
30.
Saito T, Dworacki G, Gooding W, Lotze MT, Whiteside TL: Spontaneous apoptosis of CD8+ T lymphocytes in peripheral blood of patients with advanced melanoma. Clin Cancer Res. 2000, 6: 1351-64.
31.
Curiel TJ, Coukos G, Zou L, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature medicine. 2004, 10: 942-9. 10.1038/nm1093.CrossRef
32.
Sombroek CC, Stam AG, Masterson AJ, et al: Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation. J Immunol. 2002, 168: 4333-43.CrossRef
33.
Della Bella S, Gennaro M, Vaccari M, et al: Altered maturation of peripheral blood dendritic cells in patients with breast cancer. British journal of cancer. 2003, 89: 1463-72. 10.1038/sj.bjc.6601243.CrossRef
34.
Lissoni P, Vigore L, Ferranti R, et al: Circulating dendritic cells in early and advanced cancer patients: diminished percent in the metastatic disease. Journal of biological regulators and homeostatic agents. 1999, 13: 216-9.
35.
Huang A, Gilmour JW, Imami N, Amjadi P, Henderson DC, Allen-Mersh TG: Increased serum transforming growth factor-beta1 in human colorectal cancer correlates with reduced circulating dendritic cells and increased colonic Langerhans cell infiltration. Clinical and experimental immunology. 2003, 134: 270-8. 10.1046/j.1365-2249.2003.02295.x.CrossRef
36.
Hoffmann TK, Muller-Berghaus J, Ferris RL, Johnson JT, Storkus WJ, Whiteside TL: Alterations in the frequency of dendritic cell subsets in the peripheral circulation of patients with squamous cell carcinomas of the head and neck. Clin Cancer Res. 2002, 8: 1787-93.
37.
Tuettenberg A, Schmitt E, Knop J, Jonuleit H: Dendritic cell-based immunotherapy of malignant melanoma: success and limitations. J Dtsch Dermatol Ges. 2007, 5: 190-6. 10.1111/j.1610-0387.2007.06179.x.CrossRef
38.
Liyanage UK, Moore TT, Joo HG, et al: Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol. 2002, 169: 2756-61.CrossRef
39.
Lee BN, Follen M, Rodriquez G, et al: Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer. 2006, 107: 999-1007. 10.1002/cncr.22092.CrossRef
40.
Barchet W, Cella M, Colonna M: Plasmacytoid dendritic cells--virus experts of innate immunity. Seminars in immunology. 2005, 17: 253-61. 10.1016/j.smim.2005.05.008.CrossRef
41.
Della Porta M, Danova M, Rigolin GM, et al: Dendritic cells and vascular endothelial growth factor in colorectal cancer: correlations with clinicobiological findings. Oncology. 2005, 68: 276-84. 10.1159/000086784.CrossRef
42.
Gabrilovich D: Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nature reviews. 2004, 4: 941-52. 10.1038/nri1498.
43.
Tsai JP, Chen HW, Cheng ML, et al: Analysis of host versus tumor interaction in cancer patients: opposing role of transforming growth factor-beta1 and interleukin-6 in the development of in situ tumor immunity. Immunobiology. 2005, 210: 661-71. 10.1016/j.imbio.2005.07.004.CrossRef
44.
Bellone G, Carbone A, Smirne C, et al: Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells. J Immunol. 2006, 177: 3448-60.CrossRef
45.
Gabrilovich DI, Corak J, Ciernik IF, Kavanaugh D, Carbone DP: Decreased antigen presentation by dendritic cells in patients with breast cancer. Clin Cancer Res. 1997, 3: 483-90.
Metadata
Title
Alterations of dendritic cell subsets in the peripheral circulation of patients with cervical carcinoma
Authors
Feng Ye
Yan Yu
Yuting Hu
Weiguo Lu
Xing Xie
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Journal of Experimental & Clinical Cancer Research / Issue 1/2010
Electronic ISSN: 1756-9966
DOI
https://doi.org/10.1186/1756-9966-29-78

Other articles of this Issue 1/2010

Journal of Experimental & Clinical Cancer Research 1/2010 Go to the issue

Research

Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro

Research

Co-expression and impact of prostate specific membrane antigen and prostate specific antigen in prostatic pathologies

Research

Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy

Research

Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1

Research

Multi-detector row computed tomography (MDCT) and magnetic resonance imaging (MRI) in the evaluation of the mandibular invasion by squamous cell carcinomas (SCC) of the oral cavity. Correlation with pathological data

Research

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits