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01-01-2016 | Original Article

Alterations in atherogenic indices and hypolipidemic effect of soybean oil in normocholesteremic rats

Authors: Ochuko L. Erukainure, John A. Ajiboye, Babatunde A. Lawal, Okukwe C. Obode, Emeka E. Okoro, Adesewa O. Amisu – Tugbobo, Moses Z. Zaruwa

Published in: Comparative Clinical Pathology | Issue 1/2016

Abstract

The cardiovascular protective and hypolipidemia effects of soybean oil were investigated in normocholesteremic rats. Diets were prepared and designed to contain 50 % of energy as carbohydrate, 35 % as fat, and 15 % as protein. Groups of six rats were each fed one of these diets, while a group was fed pelletized mouse chow which served as the control. A significant reduction (p < 0.05) was observed in the cholesterol, triglyceride, and low-density lipoprotein (LDL) levels of the soybean oil fed group. There was no significant alteration in the high-density lipoprotein (HDL) levels of all the groups. The studied atherogenic indices were significantly low in the soybean oil fed group compared to the other groups. These results indicate a protective effect of soybean oil against the development of cardiovascular disease as well as the hyperlipidemia that characterize obesity, hypertension, and diabetes mellitus.

Dixit AK, Antony JIX, Sharma NK, Tiwari RK (2011) Soybean constituents and their functional benefits. In: opportunity, challenge and scope of natural products in medicinal chemistry. Research Signpost, India

Dobiásová M (2004) Atherogenic index of plasma [log(triglyceride/HDL-cholesterol)]: theoretical and practical implications. Clin Chem 50:1113–1115CrossRefPubMed

Eisenmann JC (2003) Secular trends in variables associated with the metabolic syndrome of North American children and adolescents: a review and synthesis. Am J Human Biol 15:786–94CrossRef

Erukainure OL, Abovwe JA, Adefegha AS, Egwuche RU, Fafunso MA (2011) Antilipemic and hypocholesteremic activities of Globimetula braunii in rats. Exper Toxic Pathol 63:657–661CrossRef

Friedwald WT, Levy RT, Frederickson DS (1972) Estimation of the concentration of low lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem 18:499–502

Gupta MK (2007) Practical guide for vegetable oil processing. AOCS Press, Urbana

Howell TJ, MacDougall DE, Jones PJH (1998) Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive oil feeding. J Lipid Res 39:892–900PubMed

Ikewuchi CJ, Ikewuchi CC (2009) Alteration of plasma lipid profiles and atherogenic indices by Stachytarpheta jamaicensis L. (Vahl). Boikemistri 21(2):71–77

Jenkins DJA, Kendall CWC, Vidgen E, Augustin LSA et al (2001) High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function. Am J Clin Nutr 74:57–63PubMed

Jensen T, Stender S, Deckert T (1988) Abnormalities in plasma concentrations of lipoprotein and fibrinogen in type 1 (insulin-dependent) diabetic patients with increased urinary albumin excretion. Diabetologia 31:142–145CrossRefPubMed

Karasulu HY, Karasulu E, Büyükhelvacıgil M, Yıldız M, et al. (2011) Soybean oil: production process, benefits and uses in pharmaceutical dosage form. In: Soybean and health; El-Shemy H (Ed). InTech

Kummerow FA, Mahfouz MM, Zhou Q (2007) Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. Prostaglandins Other Lipid Mediat 84(3–4):138–153CrossRefPubMed

Lu C, Liu Y (2002) Interactions of lipoic acid radical cations with vitamins C and E analogue and hydroxycinnamic acid derivatives. Arch Bioc Biophy 406:78–84CrossRef

McCrindle BW (2006) Hyperlipidemia in children. Thromb Res 118:49–58CrossRefPubMed

Ojieh GC, Idokpesi GO, Eidangbe GO, Omage K, Oluba OM (2009) Hydrogenation impairs the hypolipidemic and antioxidant effects of palm oil in rats. Int J Phy Sci 4(7):407–411

Onat A, Can G, Kaya H, Hergenc G (2010) Atherogenic index of plasma” (log10 triglyceride/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events. J Clin Lipid 4:89–98CrossRef

Rang HP, Dale MM, Ritter JM, Moore PK (2005) Pharmacology, 5th edn. Elsevier, India

Takasaki Y (2005) Serum lipid levels and factors affecting atherogenic index in Japanese children. J Physiol Anthrop Appl Hum Sci 24:511–515CrossRef

Wong WW, Smith EO, Stuff JE, Hachey DL, Heird WC, Pownell HJ (1998) Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men. Am J Clin Nutr 68(suppl):1385S–1389SPubMed

Title: Alterations in atherogenic indices and hypolipidemic effect of soybean oil in normocholesteremic rats
Authors: Ochuko L. Erukainure
John A. Ajiboye
Babatunde A. Lawal
Okukwe C. Obode
Emeka E. Okoro
Adesewa O. Amisu – Tugbobo
Moses Z. Zaruwa
Publication date: 01-01-2016
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 1/2016
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-015-2142-8

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Alterations in atherogenic indices and hypolipidemic effect of soybean oil in normocholesteremic rats

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