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American Journal of Clinical Dermatology
Published in: American Journal of Clinical Dermatology 1/2023

18-11-2022 | Alopecia | Review Article

Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021

Authors: Elisabeth A. George, Caneisaya Matthews, Fritzlaine C. Roche, Susan C. Taylor

Published in: American Journal of Clinical Dermatology | Issue 1/2023

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Abstract

Central centrifugal cicatricial alopecia (CCCA) is a form of scarring alopecia that predominantly affects middle-aged women of African descent. Recent data suggest a multifactorial etiology of CCCA that is influenced by environmental and genetic factors. Emerging evidence regarding the genetic basis of the condition may elucidate new therapies. While topical and intralesional steroids and tetracycline antibiotics are the mainstay of treatment, refractory cases may be considered for hair transplantation. Emerging therapies using platelet-rich plasma, botanical formulas, and cosmetic procedures have shown promising results for the future management of CCA. As recent notable advances in CCCA have been achieved, this review provides an update on the epidemiology, pathophysiology, and management of CCCA.
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Metadata
Title
Beyond the Hot Comb: Updates in Epidemiology, Pathogenesis, and Treatment of Central Centrifugal Cicatricial Alopecia from 2011 to 2021
Authors
Elisabeth A. George
Caneisaya Matthews
Fritzlaine C. Roche
Susan C. Taylor
Publication date
18-11-2022
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 1/2023
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-022-00740-w

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