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Archives of Dermatological Research
Published in: Archives of Dermatological Research 8/2019

01-10-2019 | Alopecia | Original Paper

Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial

Authors: Moustafa A. El Taieb, Eisa M. Hegazy, Hassan M. Ibrahim, Asmaa B. Osman, Manal Abualhamd

Published in: Archives of Dermatological Research | Issue 8/2019

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Abstract

Alopecia areata is a chronic relapsing autoimmune inflammatory hair disorder with no novel therapy. The objectives of this study are to compare the efficacy of topical calcipotriol vs narrow band ultraviolet B phototherapy (NB-UVB) in the treatment of alopecia areata and its correlation with serum vitamin D3 levels. A randomized-controlled trial has been conducted on 60 patients with scalp alopecia areata randomized into four groups; topical calcipotriol, NB-UVB, both and placebo. All patients were evaluated by assessment of severity of alopecia areata by severity of alopecia tool (SALT) score at baseline and 3 months after treatment and vitamin D3 levels at baseline and after 3 months. SALT score and vitamin D3 levels were significantly improved in all groups except placebo after treatment with (P = 0.026, P = 0.005, P = 0.004, P = 0.140) and (P = 0.028, P = 0.011, P = 0.003, P = 0.725), respectively. Combined therapy showed non-significant improvement in SALT score (P = 0.530, P = 0.643), respectively, and significant improvement in serum vitamin D3 levels than each line alone with (P = 0.021, P = 0.044), respectively. Both topical calcipotriol and NB-UVB are effective therapies in the treatment of AA and associated with improvement of SALT score and vitamin D3 levels.
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Metadata
Title
Topical calcipotriol vs narrowband ultraviolet B in treatment of alopecia areata: a randomized-controlled trial
Authors
Moustafa A. El Taieb
Eisa M. Hegazy
Hassan M. Ibrahim
Asmaa B. Osman
Manal Abualhamd
Publication date
01-10-2019
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 8/2019
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-019-01943-8

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