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European Archives of Oto-Rhino-Laryngology

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01-06-2021 | Allergic Rhinitis | Otology

Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production

Authors: Ljiljana Čvorović, Aleksandar Trivić, Zoran Dudvarski, Ana Jotić, Miljan Folić, Nenad Arsović, Zoran Bukumirić, Uglješa Grgurević, Danilo Vojvodić, Aleksandar Perić

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2021

Abstract

Purpose

Otitis media with effusion (OME) associated with Samter’s triad (ST) is a difficult entity to treat. The aim of study was an investigation of the middle ear and nasal production of inflammatory mediators (IM) in patients with ST and analysing differences between them and controls.

Methods

Prospective case–control study. Nineteen patients with OME (five had allergic rhinitis, four had nasopharyngeal lymphoid hyperplasia, five had no evident sino-nasopharyngeal disease and five had confirmed ST) and 15 healthy participants were included. The concentrations of IM interleukin–1 beta (IL-1β), interferon-alpha 2 (IFN-α2), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1), IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23 and IL-33 were measured in nasal and middle ear secretions.

Results

There was a difference that was close to a level of statistical significance only for IL-1β levels in middle ear fluid (p = 0.052) between the ST subgroup and the other patients with OME. Also, we found a significant difference for IL-23 in nasal secretions between these subgroups (p = 0.040), whereas the difference in nasal fluid IL-33 was close to a level of statistical significance (p = 0.052). There was a significant difference in nasal concentrations of IL-1β, IFN-α2, MCP-1, IL-8, IL-18 and IL-33 (p < 0.001, p = 0.005, p = 0.008, p = 0.011, p = 0.011 and p = 0.011, respectively) between the OME group and the healthy subjects. There were significant positive correlations between concentrations of IL-1β, IFN-α2, IFN-γ, TNF-α, MCP-1, IL-17A, IL-18 and IL-33 (p < 0.001, p < 0.001, p = 0.002, p = 0.028, p < 0.001, p < 0.001, p < 0.001 and p < 0.001, respectively) in nasal and middle ear secretions.

Conclusion

This preliminary report showed some differences in IM production between the patients with OME associated with ST and those without it. Our results suggest a uniformity of the production of nasal and middle ear IM and supported the concept of a united airway respiratory disease.

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Title: Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production
Authors: Ljiljana Čvorović
Aleksandar Trivić
Zoran Dudvarski
Ana Jotić
Miljan Folić
Nenad Arsović
Zoran Bukumirić
Uglješa Grgurević
Danilo Vojvodić
Aleksandar Perić
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keyword: Allergic Rhinitis
Published in: European Archives of Oto-Rhino-Laryngology / Issue 6/2021
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-06276-1

At a glance: The STEP trials

Springer Medicine

Is otitis media with effusion associated with Samter’s triad a new nosological entity? A preliminary report on inflammatory mediator production

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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