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01-05-2014 | ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS)

Allergen Ligands in the Initiation of Allergic Sensitization

Author: Wayne R. Thomas

Published in: Current Allergy and Asthma Reports | Issue 5/2014

Abstract

As investigations into the innate immune responses that lead to allergic sensitization become better defined, there is a need to determine how allergens could interact with pattern recognition receptors that bind non-proteinaceous moieties. Many important allergens are not covalently bound to lipid or carbohydrate, but have structures belonging to lipid, glycan and glycolipid-binding families. These include ML-domain proteins, lipopolysaccharide-binding/cell permeability-increasing proteins, von Ebner gland lipocalins, salivary lipocalins/major urinary proteins, plant pathogenesis-related proteins PR-5 and -10, uteroglobins, non-specific lipid transfer proteins, large lipid transfer proteins and proteins with chitin and other carbohydrate-binding modules. The binding expected is overviewed with regard to importance of the allergens and their ability to elicit responses proposed from experimental models. The evidence compiled showing that allergens from the same source sensitize for different types of adaptive immune responses supports the concept that individual allergens within these sources have their own distinctive interactions with innate immunity.

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Title: Allergen Ligands in the Initiation of Allergic Sensitization
Author: Wayne R. Thomas
Publication date: 01-05-2014
Publisher: Springer US
Published in: Current Allergy and Asthma Reports / Issue 5/2014
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-014-0432-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Allergen Ligands in the Initiation of Allergic Sensitization

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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