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BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Research article

Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study

Authors: Denise HE Maasland, Piet A van den Brandt, Bernd Kremer, R Alexandra (Sandra) Goldbohm, Leo J Schouten

Published in: BMC Cancer | Issue 1/2014

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Abstract

Background

Prospective data on alcohol consumption, cigarette smoking and risk of head-neck cancer (HNC) subtypes, i.e. oral cavity cancer (OCC), oro-/hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), are limited. We investigated these associations within the second largest prospective study on this topic so far, the Netherlands Cohort Study.

Methods

120,852 participants completed a questionnaire on diet and other cancer risk factors in 1986. After 17.3 years of follow-up, 395 HNC (110 OCC, 83 OHPC, and 199 LC) cases and 4288 subcohort members were available for case-cohort analysis using Cox proportional hazards models.

Results

For total HNC, the multivariable adjusted incidence rate ratio (RR) was 2.74 (95% confidence interval (CI) 1.85-4.06) for those drinking ≥30 g ethanol/day compared with abstainers; in subtypes, RRs were 6.39 for OCC, 3.52 for OHPC, and 1.54 for LC. Compared with never cigarette smokers, current cigarette smokers had a RR of 4.49 (95%CI 3.11-6.48) for HNC overall, and 2.11 for OCC, 8.53 for OHPC, and 8.07 for LC. A significant, positive, multiplicative interaction between categories of alcohol consumption and cigarette smoking was found for HNC overall (P interaction 0.03).

Conclusions

Alcohol consumption and cigarette smoking were independently associated with risk of HNC overall, with a positive, multiplicative interaction. The strength of these associations differed among HNC-subtypes: OCC was most strongly associated with alcohol consumption but most weakly with cigarette smoking, whereas LC was not statistically significantly associated with alcohol consumption.
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Literature
1.
Argiris A, Karamouzis MV, Raben D, Ferris RL: Head and neck cancer. Lancet. 2008, 371 (9625): 1695-1709. 10.1016/S0140-6736(08)60728-X.CrossRefPubMed
2.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C: D.M. P: GLOBOCAN 2008 v1.2, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. 2010, Lyon, France: International Agency for Research on Cancer, Available from: http://​globocan.​iarc.​fr, accessed on 30/05/2013
3.
World Cancer Research Fund: American Institute for Cancer Research: Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective. 2007, Washington DC: American Institute for Cancer Research
4.
IARC: Monographs on the evaluation of carcinogenic risks to humans: alcohol drinking. 1988, Lyon: International Agency for Research on Cancer
5.
IARC: Monographs on the evaluation of carcinogenic risks to humans: tobacco smoke and involuntary smoking. 2004, Lyon: International Agency for Research on Cancer
6.
Bagnardi V, Blangiardo M, La Vecchia C, Corrao G: Alcohol consumption and the risk of cancer: a meta-analysis. Alcohol Res Health. 2001, 25 (4): 263-270.PubMed
7.
Gandini S, Botteri E, Iodice S, Boniol M, Lowenfels AB, Maisonneuve P, Boyle P: Tobacco smoking and cancer: a meta-analysis. Int J Cancer. 2008, 122 (1): 155-164. 10.1002/ijc.23033.CrossRefPubMed
8.
Lubin JH, Purdue M, Kelsey K, Zhang ZF, Winn D, Wei Q, Talamini R, Szeszenia-Dabrowska N, Sturgis EM, Smith E, Shangina O, Schwartz SM, Rudnai P, Neto JE, Muscat J, Morgenstern H, Menezes A, Matos E, Mates IN, Lissowska J, Levi F, Lazarus P, La Vecchia C, Koifman S, Herrero R, Franceschi S, Wünsch-Filho V, Fernandez L, Fabianova E, Daudt AW, et al: Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies. Am J Epidemiol. 2009, 170 (8): 937-947. 10.1093/aje/kwp222.CrossRefPubMedPubMedCentral
9.
Boeing H: Alcohol and risk of cancer of the upper gastrointestinal tract: first analysis of the EPIC data. IARC Sci Publ. 2002, 156: 151-154.PubMed
10.
Freedman ND, Abnet CC, Leitzmann MF, Hollenbeck AR, Schatzkin A: Prospective investigation of the cigarette smoking-head and neck cancer association by sex. Cancer. 2007, 110 (7): 1593-1601. 10.1002/cncr.22957.CrossRefPubMed
11.
Freedman ND, Schatzkin A, Leitzmann MF, Hollenbeck AR, Abnet CC: Alcohol and head and neck cancer risk in a prospective study. Br J Cancer. 2007, 96 (9): 1469-1474.PubMedPubMedCentral
12.
Gronbaek M, Becker U, Johansen D, Tonnesen H, Jensen G, Sorensen TI: Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract. BMJ. 1998, 317 (7162): 844-847.CrossRefPubMedPubMedCentral
13.
Kato I, Nomura AM, Stemmermann GN, Chyou PH: Prospective study of the association of alcohol with cancer of the upper aerodigestive tract and other sites. Cancer Causes Control. 1992, 3 (2): 145-151. 10.1007/BF00051654.CrossRefPubMed
14.
Kjaerheim K, Gaard M, Andersen A: The role of alcohol, tobacco, and dietary factors in upper aerogastric tract cancers: a prospective study of 10,900 Norwegian men. Cancer Causes Control. 1998, 9 (1): 99-108. 10.1023/A:1008809706062.CrossRefPubMed
15.
Zheng W, Sellers TA, Doyle TJ, Kushi LH, Potter JD, Folsom AR: Retinol, antioxidant vitamins, and cancers of the upper digestive tract in a prospective cohort study of postmenopausal women. Am J Epidemiol. 1995, 142 (9): 955-960.PubMed
16.
Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Kelsey K, Koifman S, La Vecchia C, Lazarus P, Levi F, Lence JJ, Mates D, Matos E, Menezes A, McClean MD, Muscat J, Eluf-Neto J, Olshan AF, Purdue M, Rudnai P, et al: Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev. 2009, 18 (2): 541-550. 10.1158/1055-9965.EPI-08-0347.CrossRefPubMedPubMedCentral
17.
Goldstein BY, Chang SC, Hashibe M, La Vecchia C, Zhang ZF: Alcohol consumption and cancers of the oral cavity and pharynx from 1988 to 2009: an update. Eur J Cancer Prev. 2010, 19 (6): 431-465. 10.1097/CEJ.0b013e32833d936d.CrossRefPubMedPubMedCentral
18.
IARC: Monographs on the evaluation of carcinogenic risks to humans: personal habits and indoor combustions. 2012, Lyon: International Agency for Research on Cancer
19.
van den Brandt PA, Goldbohm RA, Van ’t Veer P, Volovics A, Hermus RJ, Sturmans F: A large-scale prospective cohort study on diet and cancer in The Netherlands. J Clin Epidemiol. 1990, 43 (3): 285-295. 10.1016/0895-4356(90)90009-E.CrossRefPubMed
20.
Barlow WE, Ichikawa L, Rosner D, Izumi S: Analysis of case-cohort designs. J Clin Epidemiol. 1999, 52 (12): 1165-1172. 10.1016/S0895-4356(99)00102-X.CrossRefPubMed
21.
van den Brandt PA, Schouten LJ, Goldbohm RA, Dorant E, Hunen PM: Development of a record linkage protocol for use in the Dutch Cancer Registry for Epidemiological Research. Int J Epidemiol. 1990, 19 (3): 553-558. 10.1093/ije/19.3.553.CrossRefPubMed
22.
Goldbohm RA, Van den Brandt PA, Dorant E: Estimation of the coverage of Dutch municipalities by cancer registries and PALGA based on hospital discharge data. Tijdschr Soc Gezondheidsz. 1994, 72: 80-84.
23.
Hashibe M, Brennan P, Benhamou S, Castellsague X, Chen C, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wünsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, La Vecchia C, Lazarus P, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Schwartz SM, Smith E, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, et al: Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst. 2007, 99 (10): 777-789. 10.1093/jnci/djk179.CrossRefPubMed
24.
Fritz AG: International Classification of Diseases for Oncology: ICD-O. 2000, Geneva: World Health Organization, 3
25.
NEVO table: Dutch food composition table, 1986-1987. The Hague. 1986, the Netherlands: Voorlichtingbureau Voor de Voeding
26.
Brants HAM, Den Breeijen H: Beschrijving en verantwoording van de codering van NEVO-codes, standaardporties e.d. (Description of and justification for coding of the NEVO-codes, standardized serving sizes, etc. [in Dutch]). 1990, Zeist, the Netherlands: Institution CIVO - Toxicology and Nutrition TNO
27.
Bongaerts BW, van den Brandt PA, Goldbohm RA, De Goeij AF, Weijenberg MP: Alcohol consumption, type of alcoholic beverage and risk of colorectal cancer at specific subsites. Int J Cancer. 2008, 123 (10): 2411-2417. 10.1002/ijc.23774.CrossRefPubMed
28.
Goldbohm RA, van den Brandt PA, Brants HA, van’t Veer P, Al M, Sturmans F, Hermus RJ: Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur J Clin Nutr. 1994, 48 (4): 253-265.PubMed
29.
Goldbohm RA, Van ’t Veer P, Van Den Brandt PA, Van ’t Hof MA, Brants HA, Sturmans F, Hermus RJ: Reproducibility of a food frequency questionnaire and stability of dietary habits determined from five annually repeated measurements. Eur J Clin Nutr. 1995, 49 (6): 420-429.PubMed
30.
Negri E, Boffetta P, Berthiller J, Castellsague X, Curado MP, Dal Maso L, Daudt AW, Fabianova E, Fernandez L, Wunsch-Filho V, Franceschi S, Hayes RB, Herrero R, Koifman S, Lazarus P, Lence JJ, Levi F, Mates D, Matos E, Menezes A, Muscat J, Eluf-Neto J, Olshan AF, Rudnai P, Shangina O, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Wei Q, Winn DM, et al: Family history of cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Int J Cancer. 2009, 124 (2): 394-401. 10.1002/ijc.23848.CrossRefPubMedPubMedCentral
31.
Galeone C, Tavani A, Pelucchi C, Turati F, Winn DM, Levi F, Yu GP, Morgenstern H, Kelsey K, Dal Maso L, Purdue MP, McClean M, Talamini R, Hayes RB, Franceschi S, Schantz S, Zhang ZF, Ferro G, Chuang SC, Boffetta P, La Vecchia C, Hashibe M: Coffee and tea intake and risk of head and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium. Cancer Epidemiol Biomarkers Prev. 2010, 19 (7): 1723-1736. 10.1158/1055-9965.EPI-10-0191.CrossRefPubMedPubMedCentral
32.
Barlow WE: Robust variance estimation for the case-cohort design. Biometrics. 1994, 50 (4): 1064-1072. 10.2307/2533444.CrossRefPubMed
33.
Schoenfeld D: Partial residuals for the proportional hazards regression model. Biometrika. 1982, 69 (1): 239-241. 10.1093/biomet/69.1.239.CrossRef
34.
Leffondre K, Abrahamowicz M, Siemiatycki J, Rachet B: Modeling smoking history: a comparison of different approaches. Am J Epidemiol. 2002, 156 (9): 813-823. 10.1093/aje/kwf122.CrossRefPubMed
35.
Wacholder S, Gail MH, Pee D, Brookmeyer R: Alternative Variance and Efficiency Calculations for the Case-Cohort Design. Biometrika. 1989, 76 (1): 117-123. 10.1093/biomet/76.1.117.CrossRef
36.
De Vogel S, Dindore V, Van Engeland M, Goldbohm RA, van den Brandt PA, Weijenberg MP: Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr. 2008, 138 (12): 2372-2378. 10.3945/jn.108.091157.CrossRefPubMed
37.
Pelucchi C, Gallus S, Garavello W, Bosetti C, La Vecchia C: Alcohol and tobacco use, and cancer risk for upper aerodigestive tract and liver. Eur J Cancer Prev. 2008, 17 (4): 340-344.CrossRefPubMed
38.
Chyou PH, Nomura AM, Stemmermann GN: Diet, alcohol, smoking and cancer of the upper aerodigestive tract: a prospective study among Hawaii Japanese men. Int J Cancer. 1995, 60 (5): 616-621. 10.1002/ijc.2910600508.CrossRefPubMed
39.
Boffetta P, Hashibe M: Alcohol and cancer. Lancet Oncol. 2006, 7 (2): 149-156. 10.1016/S1470-2045(06)70577-0.CrossRefPubMed
40.
Bagnardi V, Blangiardo M, La Vecchia C, Corrao G: A meta-analysis of alcohol drinking and cancer risk. Br J Cancer. 2001, 85 (11): 1700-1705. 10.1054/bjoc.2001.2140.CrossRefPubMedPubMedCentral
41.
Zeka A, Gore R, Kriebel D: Effects of alcohol and tobacco on aerodigestive cancer risks: a meta-regression analysis. Cancer Causes Control. 2003, 14 (9): 897-906.CrossRefPubMed
42.
Purdue MP, Hashibe M, Berthiller J, La Vecchia C, Dal Maso L, Herrero R, Franceschi S, Castellsague X, Wei Q, Sturgis EM, Morgenstern H, Zhang ZF, Levi F, Talamini R, Smith E, Muscat J, Lazarus P, Schwartz SM, Chen C, Neto JE, Wünsch-Filho V, Zaridze D, Koifman S, Curado MP, Benhamou S, Matos E, Szeszenia-Dabrowska N, Olshan AF, Lence J, Menezes A, et al: Type of alcoholic beverage and risk of head and neck cancer–a pooled analysis within the INHANCE Consortium. Am J Epidemiol. 2009, 169 (2): 132-142.CrossRefPubMed
43.
Balder HF, Goldbohm RA, van den Brandt PA: Dietary patterns associated with male lung cancer risk in the Netherlands Cohort Study. Cancer Epidemiol Biomarkers Prev. 2005, 14 (2): 483-490. 10.1158/1055-9965.EPI-04-0353.CrossRefPubMed
44.
Marron M, Boffetta P, Zhang ZF, Zaridze D, Wunsch-Filho V, Winn DM, Wei Q, Talamini R, Szeszenia-Dabrowska N, Sturgis EM, Smith E, Schwartz SM, Rudnai P, Purdue MP, Olshan AF, Eluf-Neto J, Muscat J, Morgenstern H, Menezes A, McClean M, Matos E, Mates IN, Lissowska J, Levi F, Lazarus P, La Vecchia C, Koifman S, Kelsey K, Herrero R, Hayes RB, et al: Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 2010, 39 (1): 182-196. 10.1093/ije/dyp291.CrossRefPubMed
45.
D’Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML: Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007, 356 (19): 1944-1956. 10.1056/NEJMoa065497.CrossRefPubMed
46.
Hobbs CG, Sterne JA, Bailey M, Heyderman RS, Birchall MA, Thomas SJ: Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin Otolaryngol. 2006, 31 (4): 259-266. 10.1111/j.1749-4486.2006.01246.x.CrossRefPubMed
47.
Curado MP, Hashibe M: Recent changes in the epidemiology of head and neck cancer. Curr Opin Oncol. 2009, 21 (3): 194-200. 10.1097/CCO.0b013e32832a68ca.CrossRefPubMed
48.
Marur S, Forastiere AA: Head and neck cancer: changing epidemiology, diagnosis, and treatment. Mayo Clin Proc. 2008, 83 (4): 489-501. 10.4065/83.4.489.CrossRefPubMed
49.
Mehanna H, Beech T, Nicholson T, El-Hariry I, McConkey C, Paleri V, Roberts S: Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region. Head Neck. 2012, 35 (5): 747-755.CrossRefPubMed
50.
Dobrossy L: Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev. 2005, 24 (1): 9-17. 10.1007/s10555-005-5044-4.CrossRefPubMed
Metadata
Title
Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study
Authors
Denise HE Maasland
Piet A van den Brandt
Bernd Kremer
R Alexandra (Sandra) Goldbohm
Leo J Schouten
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-187

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