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Osteoporosis International

Published in:

01-02-2015 | Original Article

Alcohol consumption and hip fracture risk

Authors: X. Zhang, Z. Yu, M. Yu, X. Qu

Published in: Osteoporosis International | Issue 2/2015

Abstract

Summary

The present meta-analysis shows that a nonlinear association between alcohol consumption and the risk of hip fracture was observed. Light alcohol consumption was inversely significantly associated with hip fracture risk, whereas heavy alcohol consumption was associated with an elevated hip fracture risk.

Introduction

Previous studies examining the association between alcohol consumption and the risk of hip fracture have reported conflicting findings. Therefore, we conducted a meta-analysis of prospective cohort studies to assess the association between alcohol consumption and the risk of hip fracture.

Methods

PubMed and EMBASE were searched for prospective cohort studies on the relationship between alcohol consumption and the risk of hip fractures. Relative risks (RR) with 95 % confidence intervals (CI) were derived using random-effects models throughout the whole analysis.

Results

Eighteen prospective cohort studies were included with 3,730,424 participants and 26,168 hip fracture cases. Compared with non-drinkers, the pooled RR of hip fractures for alcohol consumption was 1.03 (95 % CI, 0.91–1.15), with high heterogeneity between studies (P < 0.001, I ² = 72.6 %). A nonlinear relationship between alcohol consumption and the risk of hip fracture was identified (P _nonlinearity = 0.003). Compared with non-drinkers, the pooled RRs of hip fractures were 0.88 (95 % CI, 0.83–0.89) for light alcohol consumption (0.01–12.5 g/day), 1.00 (95 % CI, 0.85–1.14) for moderate alcohol consumption (12.6–49.9 g/day), and 1.71 (95 % CI, 1.41–2.01) for heavy alcohol consumption (≥50 g/day).

Conclusions

There was no evidence of publication bias. In conclusion, a nonlinear association between alcohol consumption and the risk of hip fracture was observed in this meta-analysis. Further, light alcohol consumption was inversely significantly associated with hip fracture risk, whereas heavy alcohol consumption was associated with an elevated hip fracture risk.

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Title: Alcohol consumption and hip fracture risk
Authors: X. Zhang
Z. Yu
M. Yu
X. Qu
Publication date: 01-02-2015
Publisher: Springer London
Published in: Osteoporosis International / Issue 2/2015
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-014-2879-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Alcohol consumption and hip fracture risk

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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