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01-02-2018 | Original Article

Alcohol Consumption and Aneurysmal Subarachnoid Hemorrhage

Authors: Anil Can, Victor M. Castro, Yildirim H. Ozdemir, Sarajune Dagen, Dmitriy Dligach, Sean Finan, Sheng Yu, Vivian Gainer, Nancy A. Shadick, Guergana Savova, Shawn Murphy, Tianxi Cai, Scott T. Weiss, Rose Du

Published in: Translational Stroke Research | Issue 1/2018

Abstract

Alcohol consumption may be a modifiable risk factor for rupture of intracranial aneurysms. Our aim is to evaluate the association between ruptured aneurysms and alcohol consumption, intensity, and cessation. The medical records of 4701 patients with 6411 radiographically confirmed intracranial aneurysms diagnosed at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016 were reviewed. Individuals were divided into cases with ruptured aneurysms and controls with unruptured aneurysms. Univariable and multivariable logistic regression analyses were performed to determine the association between alcohol consumption and rupture of intracranial aneurysms. In multivariable analysis, current alcohol use (OR 1.36, 95% CI 1.17–1.58) was associated with rupture status compared with never drinkers, whereas former alcohol use was not significant (OR 1.23, 95% CI 0.92–1.63). In addition, the number of alcoholic beverages per day among current alcohol users (OR 1.13, 95% CI 1.04–1.23) was significantly associated with rupture status, whereas alcohol use intensity was not significant among former users (OR 1.02, 95% CI 0.94–1.11). Current alcohol use and intensity are significantly associated with intracranial aneurysm rupture. However, this increased risk does not persist in former alcohol users, emphasizing the potential importance of alcohol cessation in patients harboring unruptured aneurysms.

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Title: Alcohol Consumption and Aneurysmal Subarachnoid Hemorrhage
Authors: Anil Can
Victor M. Castro
Yildirim H. Ozdemir
Sarajune Dagen
Dmitriy Dligach
Sean Finan
Sheng Yu
Vivian Gainer
Nancy A. Shadick
Guergana Savova
Shawn Murphy
Tianxi Cai
Scott T. Weiss
Rose Du
Publication date: 01-02-2018
Publisher: Springer US
Published in: Translational Stroke Research / Issue 1/2018
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-017-0557-z

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Alcohol Consumption and Aneurysmal Subarachnoid Hemorrhage

Abstract

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Abstract

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