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BMC Geriatrics
Published in: BMC Geriatrics 1/2022

Open Access 01-12-2022 | Research

Age-related differences of vastus lateralis muscle morphology, contractile properties, upper body grip strength and lower extremity functional capability in healthy adults aged 18 to 70 years

Authors: Isobel Jacob, Mark I. Johnson, Gareth Jones, Ashley Jones, Peter Francis

Published in: BMC Geriatrics | Issue 1/2022

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Abstract

Background

There is a lack of of cross-sectional research that has investigated muscle morphology, function, and functional capability in all age-bands of healthy adults. The primary aim of this study was to evaluate age-related differences in indices of vastus lateralis (VL) muscle morphology, function and functional capability in a sample of healthy males and females aged 18-70yrs. Secondary aims were to evaluate relationships between age and VL muscle morphology and function and functional capability.

Methods

B mode Ultrasonography and Tensiomyography were used to measure VL muscle thickness, pennation angle, fascicle length, and contractile properties in 274 healthy adults aged 18-70yrs. Measurements of grip strength and functional capability (1-min chair rise test) were also taken. Data analysis included descriptive statistics, correlations, one-way ANOVAs, and multiple regressions.

Results

Negative correlations were found between age and muscle thickness (rs = -.56), pennation angle (rs = -.50), fascicle length (rs = -.30), maximal displacement (rs = -.24), grip strength (rs = -.27) and the 1-min chair rise test (rs = -.32). Positive correlations were observed between age and the echo intensity of the muscle (rs = .40) and total contraction time (rs = .20). Differences in the indices of muscle health were noticeable between the 18–29 age band and the 50–59 and 60–70 age bands (p < 0.05). The interaction of age and level of physical activity predicted changes in the variables (r2 = .04—.32).

Conclusion

Age-related differences in muscle health are noticeable at 50 years of age, and age-related differences are larger in females compared to males. It was suggested that the thickness of the VL changed the most with age across the adult lifespan and that physical activity likely acts to abate detrimental change.
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Literature
1.
Abe T, Ogawa M, Loenneke JP, Thiebaud RS, Loftin M, Mitsukawa N. Association between site-specific muscle loss of lower body and one-leg standing balance in active women: the HIREGASAKI study. Geriatr Gerontol Int. 2014;14(2):381–7.CrossRef
2.
Hairi NN, Cumming RG, Naganathan V, Handelsman DJ, Le Couteur DG, Creasey H, et al. Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2010;58(11):2055–62.CrossRef
3.
Janssen I, Heymsfield SB, Ross R. Low Relative Skeletal Muscle Mass (Sarcopenia) in Older Persons Is Associated with Functional Impairment and Physical Disability. 2002. Report No.: 00028614/02.
4.
Bohannon RW. Hand-grip dynamometry predicts future outcomes in aging adults. J Geriatr Phys Ther. 2008;31(1):3–10.CrossRef
5.
Francis P, Toomey C, Mc Cormack W, Lyons M, Jakeman P. Measurement of maximal isometric torque and muscle quality of the knee extensors and flexors in healthy 50- to 70-year-old women. Clin Physiol Funct Imaging. 2017;37(4):448–55.CrossRef
6.
Sayer AA, Syddall HE, Martin HJ, Dennison EM, Anderson FH, Cooper C. Falls, sarcopenia, and growth in early life: findings from the Hertfordshire cohort study. Am J Epidemiol. 2006;164(7):665–71.CrossRef
7.
Kawakami Y, Abe T, Fukunaga T. Muscle-fiber pennation angles are greater in hypertrophied than in normal muscles. J Appl Physiol (1985). 1993;74(6):2740–4.CrossRef
8.
Kawakami Y, Abe T, Kuno SY, Fukunaga T. Training-induced changes in muscle architecture and specific tension. Eur J Appl Physiol Occup Physiol. 1995;72(1–2):37–43.CrossRef
9.
Kawakami Y, Ichinose Y, Fukunaga T. Architectural and functional features of human triceps surae muscles during contraction. J Appl Physiol (1985). 1998;85(2):398–404.CrossRef
10.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age and Ageing: Oxford University Press; 2019. p. 16–31.
11.
Francis P, Lyons M, Piasecki M, Mc Phee J, Hind K, Jakeman P. Measurement of muscle health in aging. Biogerontology. 2017;18(6):901–11.CrossRef
12.
Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, et al. The Loss of Skeletal Muscle Strength, Mass, and Quality in Older Adults: The Health, Aging and Body Composition Study. 2006.
13.
Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MAF. Longitudinal changes in body composition in older men and women: role of body weight change and physical activity 1–4. 2002.
14.
Bodine SC. Disuse-induced muscle wasting. Int J Biochem Cell Biol. 2013;45(10):2200–8.CrossRef
15.
Oikawa SY, Holloway TM, Phillips SM. The Impact of Step Reduction on Muscle Health in Aging: Protein and Exercise as Countermeasures. Front Nutr. 2019;6:75.CrossRef
16.
Abe T, Ogawa M, Loenneke JP, Thiebaud RS, Loftin M, Mitsukawa N. Relationship between site-specific loss of thigh muscle and gait performance in women: the HIREGASAKI study. Arch Gerontol Geriatr. 2012;55(2):e21–5.CrossRef
17.
Narici MV, Maganaris CN, Reeves ND, Capodaglio P. Effect of aging on human muscle architecture. J Appl Physiol (1985). 2003;95(6):2229–34.CrossRef
18.
Macgregor LJ, Hunter AM, Orizio C, Fairweather MM, Ditroilo M. Assessment of Skeletal Muscle Contractile Properties by Radial Displacement: The Case for Tensiomyography. Sports Med. 2018;48(7):1607–20.CrossRef
19.
Simunic B, Koren K, Rittweger J, Lazzer S, Reggiani C, Rejc E, et al. Tensiomyography detects early hallmarks of bed-rest-induced atrophy before changes in muscle architecture. J Appl Physiol (1985). 2019;126(4):815–22.CrossRef
20.
Bohannon RW, Magasi SR, Bubela DJ, Wang Y-C, Gershon RC. Grip and knee extension muscle strength reflect a common construct among adults. Muscle Nerve. 2012;46(4):555–8.CrossRef
21.
Greig CA, Young A, Skelton DA, Pippet E, Butler FM, Mahmud SM. Exercise studies with elderly volunteers. Age Ageing. 1994;23(3):185–9.CrossRef
22.
Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381–95.CrossRef
23.
Jacob I, Francis P, Jones G, Johnson MI. A Protocol to measure vastus lateralis vastus muscle thickness using B mode ultrasonography. In: University LB, editor. Research Gate. 2021.
24.
Blazevich AJ, Gill ND, Zhou S. Intra- and intermuscular variation in human quadriceps femoris architecture assessed in vivo. J Anat. 2006;209(3):289–310.CrossRef
25.
Jacob I, Jones G, Francis P, Johnson MI. The effect of limb position on measured values of vastus lateralis muscle morphology using B Mode ultrasound. Translational Sports Medicine. 2021;4(6):697–705.CrossRef
26.
Martin-Rodriguez S, Loturco I, Hunter AM, Rodriguez-Ruiz D, Munguia-Izquierdo D. Reliability and Measurement Error of Tensiomyography to Assess Mechanical Muscle Function: A Systematic Review. J Strength Cond Res. 2017;31(12):3524–36.CrossRef
27.
Hunter AM, Galloway SD, Smith IJ, Tallent J, Ditroilo M, Fairweather MM, et al. Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography. J Electromyogr Kinesiol. 2012;22(3):334–41.CrossRef
28.
Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A Jr, Orlandini A, et al. Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386(9990):266–73.CrossRef
29.
Cohen J. Statistical Power Analysis for the Behavioural Sciences. New York: Routledge Academic; 1988.
30.
Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, et al. Grip strength across the life course: normative data from twelve British studies. PLoS ONE. 2014;9(12): e113637.CrossRef
31.
Kallman DA, Plato CC, Tobin JD. The role of muscle loss in the age-related decline of grip strength: cross-sectional and longitudinal perspectives. J Gerontol. 1990;45(3):M82–8.CrossRef
32.
Vianna LC, Oliveira RB, Araujo CG. Age-related decline in handgrip strength differs according to gender. J Strength Cond Res. 2007;21(4):1310–4.PubMed
33.
McDonagh MJ, Davies CT. Adaptive response of mammalian skeletal muscle to exercise with high loads. Eur J Appl Physiol Occup Physiol. 1984;52(2):139–55.CrossRef
34.
Yeung SSY, Reijnierse EM, Trappenburg MC, Blauw GJ, Meskers CGM, Maier AB. Knee extension strength measurements should be considered as part of the comprehensive geriatric assessment. BMC Geriatr. 2018;18(1):130.CrossRef
35.
Abe T, Sakamaki M, Yasuda T, Bemben MG, Kondo M, Kawakami Y, et al. Age-related, site-specific muscle loss in 1507 Japanese men and women aged 20 to 95 years. J Sports Sci Med. 2011;10(1):145–50.PubMedPubMedCentral
36.
Samson MM, Meeuwsen IB, Crowe A, Dessens JA, Duursma SA, Verhaar HJ. Relationships between physical performance measures, age, height and body weight in healthy adults. Age Ageing. 2000;29(3):235–42.CrossRef
37.
Janssen I, Heymsfield SB, Wang Z, Ross R. Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. 2000.
38.
Abe T, DeHoyos DV, Pollock ML, Garzarella L. Time course for strength and muscle thickness changes following upper and lower body resistance training in men and women. Eur J Appl Physiol. 2000;81(3):174–80.CrossRef
39.
Franchi MV, Reeves ND, Narici MV. Skeletal Muscle Remodeling in Response to Eccentric vs Concentric Loading : Morphological, Molecular, and Metabolic Adaptations. Front Physiol. 2017;8:447.CrossRef
40.
Reeves ND, Maganaris CN, Narici MV. Plasticity of dynamic muscle performance with strength training in elderly humans. Muscle Nerve. 2005;31(3):355–64.CrossRef
41.
Reeves ND, Narici MV, Maganaris CN. In vivo human muscle structure and function: adaptations to resistance training in old age. Exp Physiol. 2004;89(6):675–89.CrossRef
42.
Santos R, Valamatos MJ, Mil-Homens P, Armada-da-Silva PAS. Muscle thickness and echo-intensity changes of the quadriceps femoris muscle during a strength training program. Radiography (Lond). 2018;24(4):e75–84.CrossRef
43.
Seynnes OR, de Boer M, Narici MV. Early skeletal muscle hypertrophy and architectural changes in response to high-intensity resistance training. J Appl Physiol (1985). 2007;102(1):368–73.CrossRef
44.
Piasecki M, Ireland A, Jones DA, McPhee JS. Age-dependent motor unit remodelling in human limb muscles. Biogerontology. 2016;17(3):485–96.CrossRef
45.
McPhee JS, French DP, Jackson D, Nazroo J, Pendleton N, Degens H. Physical activity in older age: perspectives for healthy ageing and frailty. Biogerontology. 2016;17(3):567–80.CrossRef
46.
Samuel D, Wilson K, Martin HJ, Allen R, Sayer AA, Stokes M. Age-associated changes in hand grip and quadriceps muscle strength ratios in healthy adults. Aging Clin Exp Res. 2012;24(3):245–50.CrossRef
Metadata
Title
Age-related differences of vastus lateralis muscle morphology, contractile properties, upper body grip strength and lower extremity functional capability in healthy adults aged 18 to 70 years
Authors
Isobel Jacob
Mark I. Johnson
Gareth Jones
Ashley Jones
Peter Francis
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2022
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-022-03183-4

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