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01-09-2020 | Original Article

Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex

Authors: Manon Edde, Bixente Dilharreguy, Guillaume Theaud, Sandra Chanraud, Catherine Helmer, Jean-François Dartigues, Hélène Amieva, Michèle Allard, Maxime Descoteaux, Gwénaëlle Catheline

Published in: Brain Structure and Function | Issue 7/2020

Abstract

While the neural correlates of age-related episodic memory decline have been extensively studied, the precise involvement of the Posterior Cingulate Cortex (PCC) and posterior parietal cortex (the precuneus and the angular gyrus), remains unclear. The present study examined functional and structural neural correlates of age-related episodic memory change assessed over 12 years in 120 older adults (range 76–90 years). Episodic memory performance was measured using the Free and Cued Selective Reminding Test (FCSRT); functional connectivity metrics were computed from resting-state fMRI images and structural connectivity metrics were assessed through microstructural properties of reconstructed tract using a native space pipeline. We found that FCSRT change was significantly associated with the functional connectivity between the ventral PCC and three parietal regions, the ventral superior, the inferior part of the precuneus, and the rostro dorsal part of the angular gyrus. This association was independent of hippocampal volume. In addition, we found the that change in FCSRT scores was associated with fractional anisotropy of the tract connecting the ventral PCC and the ventral superior part of the precuneus. Change in episodic memory in aging was therefore related to a combination of high functional connectivity and low structural connectivity between the ventral PCC and the ventral superior part of the precuneus.

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Title: Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex
Authors: Manon Edde
Bixente Dilharreguy
Guillaume Theaud
Sandra Chanraud
Catherine Helmer
Jean-François Dartigues
Hélène Amieva
Michèle Allard
Maxime Descoteaux
Gwénaëlle Catheline
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 7/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02121-7

At a glance: The STEP trials

Springer Medicine

Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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