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Open Access 01-12-2010 | Research

Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older

Authors: Hideya Yamazaki, Ken Yoshida, Tadayuki Kotsuma, Yasuo Yoshioka, Masahiko Koizumi, Souhei Furukawa, Naoya Kakimoto, Kimishige Shimizutani, Tsunehiko Nishimura

Published in: Radiation Oncology | Issue 1/2010

Abstract

Background

To examine the role of brachytherapy for aged patients 80 or more in the trend of rapidly increasing number.

Methods

We examined the outcomes for elderly patients with node negative oral tongue cancer (T1-3N0M0) treated with brachytherapy. The 21 patients (2 T1, 14 T2, and 5 T3 cases) ranged in age from 80 to 89 years (median 81), and their cancer was pathologically confirmed. All patients underwent definitive radiation therapy, with low dose rate (LDR) Ra-226 brachytherapy (n = 4; median 70Gy), with Ir-192 (n = 12; 70Gy), with Au-198 (n = 1) or with high dose rate (HDR) Ir-192 brachytherapy (n = 4; 60 Gy). Eight patients also underwent external radiotherapy (median 30 Gy). The period of observation ranged from 13 months to 14 years (median 2.5 years). We selected 226 population matched younger counterpart from our medical chart.

Results

Definitive radiation therapy was completed for all 21 patients (100%), and acute grade 2-3 mucositis related to the therapy was tolerable. Local control (initial complete response) was attained in 19 of 21 patients (90%). The 2-year and 5-year local control rates were 91%, (100% for T1, 83% for T2 and 80% for T3 tumors after 2 years). These figures was not inferior to that of younger counterpart (82% at 5-year, n.s.). The cause-specific survival rate was 83% and the regional control rate 84% at the 2-years follow-up. However, 12 patients died because of intercurrent diseases or senility, resulting in overall survival rates of 55% at 2 years and 34% at 5 years.

Conclusion

Age is not a limiting factor for brachytherapy for appropriately selected elderly patients, and brachytherapy achieved good local control with acceptable morbidity.

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Title: Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older
Authors: Hideya Yamazaki
Ken Yoshida
Tadayuki Kotsuma
Yasuo Yoshioka
Masahiko Koizumi
Souhei Furukawa
Naoya Kakimoto
Kimishige Shimizutani
Tsunehiko Nishimura
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2010
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-5-116

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Age is not a limiting factor for brachytherapy for carcinoma of the node negative oral tongue in patients aged eighty or older

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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