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Sleep and Breathing
Published in: Sleep and Breathing 2/2016

01-05-2016 | Original Article

Age and severity matched comparison of gender differences in the prevalence of periodic limb movements during sleep in patients with obstructive sleep apnea

Authors: Rong Ren, Guoping Huang, Jihui Zhang, Junying Zhou, Yun Li, Yuanfeng Sun, Guangyao Zhou, Suxia Li, Lin Lu, Yun-Kwok Wing, Xiangdong Tang

Published in: Sleep and Breathing | Issue 2/2016

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Abstract

Purpose

The aim of this study was to investigate gender differences of periodic limb movements during sleep (PLMS) in patients with obstructive sleep apnea (OSA).

Methods

This was a case–control study recruiting 364 patients with OSA (182 men, 182 women) matched for age and apnea–hypopnea index (AHI). All participants underwent overnight polysomnography (PSG), followed by the multiple sleep latency test (MSLT) and the Epworth Sleepiness Scale (ESS).

Results

Women with OSA had a significantly higher prevalence of PLMS than men (24.2 vs. 15.9 %, p < 0.05). Women with OSA showed an increased prevalence of PLMS compared to men in the younger group aged ≤55 years (23.0 vs. 10.6 %, p < 0.05), but not in the older groups >55 years (25.3 vs. 21.6 %, p > 0.05). Binary linear regression analysis in OSA patients confirmed that women were more likely to have PLMS than men (OR 1.71, 95 % CI 1.00–2.92), particularly in patients with age ≤55 years old (OR 2.48, 95 % CI 1.06–5.79), after adjusting for age, BMI, AHI, and habits of smoking and drinking.

Conclusions

The results demonstrate that, for patients with OSA, young women had significantly increased prevalence of PLMS compared to young men, but there was no difference in prevalence of PLMS between the men and women in the older age group.
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Metadata
Title
Age and severity matched comparison of gender differences in the prevalence of periodic limb movements during sleep in patients with obstructive sleep apnea
Authors
Rong Ren
Guoping Huang
Jihui Zhang
Junying Zhou
Yun Li
Yuanfeng Sun
Guangyao Zhou
Suxia Li
Lin Lu
Yun-Kwok Wing
Xiangdong Tang
Publication date
01-05-2016
Publisher
Springer Berlin Heidelberg
Published in
Sleep and Breathing / Issue 2/2016
Print ISSN: 1520-9512
Electronic ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-015-1231-x

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