Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan | springermedicine.com

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Environmental Health and Preventive Medicine

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01-07-2016 | Regular Article

Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan

Authors: Marowa Hashimoto, Nobuyuki Miyai, Sonomi Hattori, Akihiko Iwahara, Miyoko Utsumi, Mikio Arita, Tatsuya Takeshita

Published in: Environmental Health and Preventive Medicine | Issue 4/2016

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Abstract

Objective

The influence of T-786C polymorphism in the promoter region of endothelial nitric oxide synthase (eNOS) on arteriosclerotic parameters by age and gender were examined.

Methods

Brachial-ankle pulse wave velocity (baPWV), heart-rate adjusted augmentation index (AIx@75), pulse pressure (PP) and albumin–creatinine ratio (ACR) were assessed as arteriosclerotic parameters in addition to non-high-density lipoprotein cholesterol (non-HDL-C) to HDL-C (non-HDL-C/HDL-C) ratio in 1499 participants. T-786C polymorphism (rs2070744) was screened using a TaqMan allelic discrimination assay. Analyses of covariance were carried.

Results

Women with the non-C allele showed significantly lower AIx@75 in participants aged <65 years and baPWV in participants aged ≥65 years than those with C allele. In contrast, men with the non-C allele showed significantly higher PP in participants aged <65 years, and higher ACR and non-HDL-C/HDL-C ratio in participants aged ≥65 years. In men on cholesterol-lowering medication, the non-C allele carriers showed significantly higher non-HDL-C compared to those in the C allele carriers.

Conclusions

eNOS T-786C polymorphism is significantly associated with arteriosclerotic parameters accompanied with age and gender differences, possibly involving antioxidative and/or endothelial signaling other than inflammatory signaling.

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Title: Age and gender differences in the influences of eNOS T-786C polymorphism on arteriosclerotic parameters in general population in Japan
Authors: Marowa Hashimoto
Nobuyuki Miyai
Sonomi Hattori
Akihiko Iwahara
Miyoko Utsumi
Mikio Arita
Tatsuya Takeshita
Publication date: 01-07-2016
Publisher: Springer Japan
Published in: Environmental Health and Preventive Medicine / Issue 4/2016
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-016-0527-1

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