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BMC Psychiatry

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Open Access 01-12-2021 | Mood Disorders | Research

The association between triglyceride glucose index and depression: data from NHANES 2005–2018

Authors: Yi-Yi Shi, Rui Zheng, Jie-Jie Cai, Song-Zan Qian

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

The association between triglyceride glucose (TyG) index and depression is unclear. We conducted this analysis to explore whether higher TyG index is associated with a higher odd of depression.

Methods

This was an observational study using data from the National Health and Nutrition Examination Survey (2005–2018), a cross-sectional and nationally representative database. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9). TyG index was calculated based on the equation as follows: ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2], and participants were divided into quartiles based on TyG index. Weighted multivariable logistic regression models were used to explore the relationship between the TyG index and depression.

Results

A total of 13,350 patients were included, involving 1001 (7.50%) individuals with depression. Higher TyG index is significantly associated with elevated depressive symptoms in U.S. adults. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for depression (OR = 1.46; 95% confidence interval (CI) 1.30, 1.64) compared with the 1st quartile of TyG index. Similar results were seen in men and women, across age groups, and baseline comorbidities.

Conclusion

In this large cross-sectional study, our result suggests that population with higher TyG index are significantly more likely to have depressive symptoms in U.S. adults.

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Title: The association between triglyceride glucose index and depression: data from NHANES 2005–2018
Authors: Yi-Yi Shi
Rui Zheng
Jie-Jie Cai
Song-Zan Qian
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mood Disorders
Insulins
Affective Disorder
Insulins
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03275-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The association between triglyceride glucose index and depression: data from NHANES 2005–2018

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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