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Archives of Women's Mental Health

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08-08-2023 | Mood Disorders | Original Article

The association between depression during perimenopause and progression of chronic conditions and multimorbidity: results from a Chinese prospective cohort

Authors: Bingqi Ye, Yaguan Zhou, Mengsha Chen, Chen Chen, Jie Tan, Xiaolin Xu

Published in: Archives of Women's Mental Health | Issue 5/2023

Abstract

Purpose

The association between perimenopausal depression and many chronic conditions among women has been well-established. However, the role of depression during perimenopause in the progression of multiple chronic conditions (multimorbidity) remains poorly understood.

Material and methods

A total of 1,216 community-dwelling women in their perimenopause period between 2010 and 2016 were enrolled in our analysis, and followed up for the progression of multimorbidity. Depression, as well as its severity, was evaluated by the Center for Epidemiologic Studies Depression 10-item scale (CES-D-10). Progression of multimorbidity was defined as the first report of two or more chronic conditions for participants without multimorbidity or the new report of one or more conditions for those with multimorbidity. Univariable and multivariable Cox proportional hazards model and the restricted cubic spline regression model were performed to assess the prospective association between perimenopausal depression and the progression of multimorbidity.

Results

A total of 480 (39.5%) women reported depression during perimenopause, and 529 (43.5%) women progressed to multimorbidity. After adjusting for socio-demographic and lifestyle factors, perimenopausal depression was independently associated with the progression of multimorbidity (hazard ratio [HR]: 1.34; 95% confidence interval [CI]: 1.13 to 1.60). Moreover, the severity of depression was positively and linearly associated with the progression of multimorbidity (P < 0.05).

Conclusions

Our finding reveals a prospective association between perimenopausal depression and the progression of multimorbidity, indicating interventions targeting perimenopausal depression may reduce the burden of chronic diseases and multimorbidity in women’s post-menopausal life.

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Title: The association between depression during perimenopause and progression of chronic conditions and multimorbidity: results from a Chinese prospective cohort
Authors: Bingqi Ye
Yaguan Zhou
Mengsha Chen
Chen Chen
Jie Tan
Xiaolin Xu
Publication date: 08-08-2023
Publisher: Springer Vienna
Keywords: Mood Disorders
Affective Disorder
Published in: Archives of Women's Mental Health / Issue 5/2023
Print ISSN: 1434-1816
Electronic ISSN: 1435-1102
DOI: https://doi.org/10.1007/s00737-023-01354-9

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Springer Medicine

The association between depression during perimenopause and progression of chronic conditions and multimorbidity: results from a Chinese prospective cohort

Abstract

Purpose

Material and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Material and methods

Results

Conclusions

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