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Neurological Sciences

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Open Access 02-03-2022 | Mood Disorders | Original Article

The altered multiscale dynamics of spontaneous brain activity in depression with Parkinson’s disease

Authors: Zhu Liu, Dongning Su, Lingyan Ma, Huimin Chen, Jinping Fang, Huizi Ma, Junhong Zhou, Tao Feng

Published in: Neurological Sciences | Issue 7/2022

Abstract

Background

Depression is one typical mood disorder in Parkinson’s disease (DPD). The alterations in the resting-state brain activities are believed to be associated with DPD. These resting-state activities are regulated by neurophysiological components over multiple temporal scales. The multiscale dynamics of these spontaneous fluctuations are thus complex, but not well-characterized.

Objective

To characterize the complexity of the spontaneous blood-oxygen-level-dependent (BOLD) of fMRI in DPD. We hypothesized that (1) compared to non-depression PD (NDPD), the complexity in DPD would be lower; and (2) the diminished complexity would be associated with lower connections/communications between brain regions.

Methods

Twenty-nine participants (10 in DPD and 19 in NDPD) who were naïve to medications completed a resting-sate functional MRI scan. The BOLD complexity within each voxel was calculated by using multiscale entropy (MSE). The complexity of the whole brain and each of the 90 regions parcellated following automated-anatomical-labeling template was then obtained by averaging voxel-wised complexity across all brain regions or within each region. The level of connections of regions with diminished complexity was measured by their own global functional connectivity (FC).

Results

As compared to NDPD patients, the whole-brain complexity and complexity in 18 regions were significantly lower in DPD (F > 16.3, p < 0.0005). Particularly, in eight of the 18 regions, lower complexity was associated with lower global FC (Beta = 0.333 ~ 0.611, p = 0.000 ~ 0.030).

Conclusion

The results from this pilot study suggest that the resting-state BOLD complexity may provide critical knowledge into the pathology of DPD. Future studies are thus warranted to confirm the findings of this study.

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Title: The altered multiscale dynamics of spontaneous brain activity in depression with Parkinson’s disease
Authors: Zhu Liu
Dongning Su
Lingyan Ma
Huimin Chen
Jinping Fang
Huizi Ma
Junhong Zhou
Tao Feng
Publication date: 02-03-2022
Publisher: Springer International Publishing
Keywords: Mood Disorders
Affective Disorder
Parkinson's Disease
Published in: Neurological Sciences / Issue 7/2022
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-05974-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The altered multiscale dynamics of spontaneous brain activity in depression with Parkinson’s disease

Abstract

Background

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Methods

Results

Conclusion

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