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BMC Psychiatry
Published in: BMC Psychiatry 1/2024

Open Access 01-12-2024 | Mood Disorders | Research

Sex-differential cognitive performance on MCCB of youth with BD-II depression

Authors: Dong Huang, Shunkai Lai, Shuming Zhong, Yiliang Zhang, Jiali He, Shuya Yan, Xiaosi Huang, Xiaodan Lu, Manying Duan, Kailin Song, Kaiwei Ye, Yandi Chen, Suiyi Ye, Jiankang Lai, Qilin Zhong, Xiaodong Song, Yanbin Jia

Published in: BMC Psychiatry | Issue 1/2024

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Abstract

Background

Recent evidences have shown sex-differential cognitive deficits in bipolar disorder (BD) and differences in cognitions across BD subtypes. However, the sex-specific effect on cognitive impairment in BD subtype II (BD-II) remains obscure. The aim of the current study was to examine whether cognitive deficits differ by gender in youth with BD-II depression.

Method

This cross-sectional study recruited 125 unmedicated youths with BD-II depression and 140 age-, sex-, and education-matched healthy controls (HCs). The Chinese version of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) was used to assess cognitive functions. Mood state was assessed using the 24-item Hamilton Depression Rating Scale (24-HDRS) and the Young Mania Rating Scale (YMRS). Multivariate analysis of covariance (MANCOVA) was conducted.

Result

​Compared with HCs, patients with BD-II depression had lower scores on MCCB composite and its seven cognitive domains (all p < 0.001). After controlling for age and education, MANCOVA revealed significant gender-by-group interaction on attention/vigilance (F = 6.224, df = 1, p = 0.013), verbal learning (F = 9.847, df = 1, p = 0.002), visual learning (F = 4.242, df = 1, p = 0.040), and composite (F = 8.819, df = 1, p = 0.003). Post hoc analyses suggested that males performed worse in the above-mentioned MCCB tests than females in BD-II depression.

Conclusion

Our study demonstrated generalized cognitive deficits in unmedicated youths with BD-II depression. Male patients performed more serious cognitive impairment on attention/vigilance, verbal learning, and visual learning compared to female patients.
Appendix
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Metadata
Title
Sex-differential cognitive performance on MCCB of youth with BD-II depression
Authors
Dong Huang
Shunkai Lai
Shuming Zhong
Yiliang Zhang
Jiali He
Shuya Yan
Xiaosi Huang
Xiaodan Lu
Manying Duan
Kailin Song
Kaiwei Ye
Yandi Chen
Suiyi Ye
Jiankang Lai
Qilin Zhong
Xiaodong Song
Yanbin Jia
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2024
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-024-05701-7

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