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BMC Psychiatry
Published in: BMC Psychiatry 1/2024

Open Access 01-12-2024 | Mood Disorders | Matters Arising

Inappropriate study inclusion in meta-analysis of sham-controlled rTMS for treatment-resistant depression

Author: Kevin P. Kennedy

Published in: BMC Psychiatry | Issue 1/2024

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Abstract

Dr. Vida and colleagues have published an important meta-analysis on a critical topic in psychiatry: the efficacy of double-blind, sham-controlled rTMS in treatment-resistant depression (TRD) [1]. The primary reported finding was a significant effect of rTMS on remission and response (RR 2.25 and 2.78 respectively) compared to sham rTMS. A close evaluation of the studies included in this meta-analysis raises concerns about the accuracy of these findings.
Literature
1.
Vida RG, Sághy E, Bella R, Kovács S, Erdősi D, Józwiak-Hagymásy J, et al. Efficacy of repetitive transcranial magnetic stimulation (rTMS) adjunctive therapy for major depressive disorder (MDD) after two antidepressant treatment failures: meta-analysis of randomized sham-controlled trials. BMC Psychiatry. 2023;23(1):545.CrossRefPubMedPubMedCentral
2.
Filipčić I, Šimunović Filipčić I, Milovac Ž, Sučić S, Gajšak T, Ivezić E, et al. Efficacy of repetitive transcranial magnetic stimulation using a figure-8-coil or an H1-Coil in treatment of major depressive disorder; a randomized clinical trial. J Psychiatr Res. 2019;114:113–9.CrossRefPubMed
3.
Burke MJ, Kaptchuk TJ, Pascual-Leone A. Challenges of Differential Placebo effects in Contemporary Medicine: the Example of Brain Stimulation. Ann Neurol. 2019;85(1):12–20.CrossRefPubMedPubMedCentral
4.
Duecker F, Sack AT. Rethinking the role of sham TMS. Front Psychol. 2015;6.210.
5.
Razza LB, Moffa AH, Moreno ML, et al. A systematic review and meta-analysis on placebo response to repetitive transcranial magnetic stimulation for depression trials. Prog Neuropsychopharmacol Biol Psychiatry. 2018;81:105–13.CrossRefPubMed
Metadata
Title
Inappropriate study inclusion in meta-analysis of sham-controlled rTMS for treatment-resistant depression
Author
Kevin P. Kennedy
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2024
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/s12888-024-05703-5

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