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BMC Psychiatry

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Open Access 01-12-2021 | Mood Disorders | Research

Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Authors: Yanhong Liu, Yongsheng Tong, Lvzhen Huang, Jingxu Chen, Shaoxiao Yan, Fude Yang

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

We analyzed the correlation of the clinical data with retinal nerve fiber layer (RNFL) thickness and macular thickness in bipolar disorder patients and major depression patients. The aim of this study is to explore factors that affect RNFL thickness in bipolar disorder patients and major depression patients, with a view to providing a new diagnostic strategy.

Methods

Eighty-two bipolar disorder patients, 35 major depression patients and 274 people who were age and gender matched with the patients were enrolled. Demographic information and metabolic profile of all participants were collected. Best-corrected visual acuity of each eye, intraocular pressure (IOP), fundus examination was performed. RNFL and macular thickness were measured by optical coherence tomography (OCT). Correlations between RNFL and macular thickness and other data were analyzed.

Results

RNFL and macula lutea in bipolar dipolar patients and major depression patients are thinner than normal people. Triglyceride and UA levels are the highest in the bipolar disorder group, while alanine aminotransferase (ALT) and glutamic oxalacetic transaminase (AST) levels in the depression group are the highest. Age onset and ALT are positively while uric acid (UA) is negatively correlated with RNFL thickness in bipolar dipolar patients. Cholesterol level is positively correlated with RNFL thickness while the duration of illness is correlated with RNFL thickness of left eye in major depression patients.

Conclusions

RNFL and macula lutea in bipolar dipolar patients and major depression patients are thinner than normal people. In bipolar disorder patients, age-onset and ALT are potential protective factors in the progress of RNFL thinning, while UA is the pathological factor.

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Title: Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients
Authors: Yanhong Liu
Yongsheng Tong
Lvzhen Huang
Jingxu Chen
Shaoxiao Yan
Fude Yang
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mood Disorders
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03270-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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