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The Journal of Headache and Pain

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Open Access 01-12-2022 | Mood Disorders | Research

Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients

Authors: Christelle Gremeau-Richard, Paul Pionchon, Aurélien Mulliez, Christian Dualé, Radhouane Dallel

Published in: The Journal of Headache and Pain | Issue 1/2022

Abstract

Background

Deficient endogenous pain modulation has been implicated in the development and exacerbation of chronic orofacial pain. To date, relatively little is known regarding the function of the endogenous pain modulation in patients with burning mouth syndrome (BMS). This case–control study investigated endogenous pain modulation in women with BMS.

Methods

Conditioned pain modulation (CPM) was assessed upon temporal summation (TSP) of thermal pain. Forty female subjects, 20 BMS patients and 20 age-matched control subjects, were included in a 2 session-protocol. Mechanical and thermal pain thresholds were measured on the forearm and hand. TSP was obtained using repetitive laser-evoked thermal stimuli applied on the non-dominant hand, at an intensity yielding to moderate pain. During TSP, CPM was produced by immersing the contralateral foot in a water bath at painful cold (8 °C) temperature. In control conditions, the foot was immersed in a water bath at not painful (30 °C) temperature.

Results

BMS was not associated with any impairment in thermal as well as mechanical extracephalic pain thresholds. TSP and CPM efficacy were similar in BMS patients and control subjects. However, BMS patients exhibited enhanced extracephalic heat hyperalgesia.

Conclusion

This study reveals that there is no impairment of endogenous pain inhibition mechanisms in BMS patients, but rather an increase in pain facilitation.

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Title: Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients
Authors: Christelle Gremeau-Richard
Paul Pionchon
Aurélien Mulliez
Christian Dualé
Radhouane Dallel
Publication date: 01-12-2022
Publisher: Springer Milan
Keywords: Mood Disorders
Affective Disorder
Laser
Published in: The Journal of Headache and Pain / Issue 1/2022
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI: https://doi.org/10.1186/s10194-022-01516-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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