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01-06-2020 | Mood Disorders | Neurology and Preclinical Neurological Studies - Original Article

Effects of gender on cognitive and behavioral manifestations in multiple system atrophy

Authors: Sofia Cuoco, Marina Picillo, Arianna Cappiello, Immacolata Carotenuto, Roberto Erro, Maria Claudia Russillo, Filomena Abate, Giampiero Volpe, Massimo Squillante, Autilia Cozzolino, Giulio Cicarelli, Gabriella Santangelo, Paolo Barone, Maria Teresa Pellecchia

Published in: Journal of Neural Transmission | Issue 6/2020

Abstract

Gender differences have been described in several neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. The effects of gender on cognitive and behavioral manifestations in multiple system atrophy and the changes of cognitive functions over time according to gender have not been investigated so far. Fifty-five patients with a diagnosis of multiple system atrophy underwent a comprehensive neuropsychological and neuropsychiatric battery at baseline and 26 of them could be re-evaluated at 1-year follow-up. At baseline women with multiple system atrophy had poorer global cognitive state and visuo-spatial abilities, and a higher prevalence of depression and apathy than males. At follow-up, female patients deteriorated more than males on attention abilities and motor functions, and had a higher prevalence of depression than men. Executive functions and visuo-spatial abilities significantly worsened over time in both groups. Mild Cognitive Impairment single domain was significantly more frequent in females than males. Cognitive and behavioral differences between genders in multiple system atrophy involve global cognition, planning, attention, visual-perceptive skills, and depression, with female patients more compromised than males. Female patients deteriorated more than men over time as for motor functions and attention. Further longitudinal studies are deserved to confirm gender differences in progression of cognitive and behavioral features of multiple system atrophy.

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Title: Effects of gender on cognitive and behavioral manifestations in multiple system atrophy
Authors: Sofia Cuoco
Marina Picillo
Arianna Cappiello
Immacolata Carotenuto
Roberto Erro
Maria Claudia Russillo
Filomena Abate
Giampiero Volpe
Massimo Squillante
Autilia Cozzolino
Giulio Cicarelli
Gabriella Santangelo
Paolo Barone
Maria Teresa Pellecchia
Publication date: 01-06-2020
Publisher: Springer Vienna
Keywords: Mood Disorders
Affective Disorder
Mild Neurocognitive Disorder
Parkinson's Disease
Published in: Journal of Neural Transmission / Issue 6/2020
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-020-02169-z

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Effects of gender on cognitive and behavioral manifestations in multiple system atrophy

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