A phase II open-label pilot study identified a male patient [age not stated] who developed fatigue while receiving afamelanotide. The patient had mild-to-moderate facial acne vulgaris. He started receiving afamelanotide 16mg, administered as a sustained release resorbable implant formulation and as SC injections into fat above the anterior portion of the iliac crest [frequency not stated]. He experienced mild and short-term fatigue [time to reaction onset not stated]. …