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01-06-2010 | Comorbidity and Chronicization

Advancement in idiopathic intracranial hypertension pathogenesis: focus on sinus venous stenosis

Authors: Roberto De Simone, Angelo Ranieri, Vincenzo Bonavita

Published in: Neurological Sciences | Special Issue 1/2010

Abstract

Idiopathic intracranial hypertension is consistently associated with venous outflow disturbances. Sinus venous stenosis are found at magnetic resonance venography in the large majority of IIH patients and may have various conformations, ranging from functional smooth narrowings of sinus segments associated or not with definite flow gaps, to segmental hypoplasia or aplasia of one or more central venous collectors. Stenosis are currently believed to be a consequence of a primary altered cerebrospinal fluid (CSF) pressure since it may normalize after CSF subtraction with lumbar puncture or shunting procedures. In this paper a “self-sustained venous collapse” is proposed as a crucial causative mechanism in predisposed subjects, leading to a self-sustained intracranial hypertension in presence of a wide range of triggering factors. The proposed mechanisms predict the long-term remission of IIH syndromes frequently observed after a single or few serial CSF subtractions by lumbar puncture.

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Title: Advancement in idiopathic intracranial hypertension pathogenesis: focus on sinus venous stenosis
Authors: Roberto De Simone
Angelo Ranieri
Vincenzo Bonavita
Publication date: 01-06-2010
Publisher: Springer Milan
Published in: Neurological Sciences / Issue Special Issue 1/2010
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-010-0271-z

At a glance: The STEP trials

Springer Medicine

Advancement in idiopathic intracranial hypertension pathogenesis: focus on sinus venous stenosis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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