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Published in: Langenbeck's Archives of Surgery 6/2007

01-11-2007 | Current Concepts in Clinical Surgery

Adult living donor liver transplantation: living donation of the right liver lobe

Authors: J. Mittler, A. Pascher, S. Jonas, J. Pratschke, U. P. Neumann, J. M. Langrehr, P. Neuhaus

Published in: Langenbeck's Archives of Surgery | Issue 6/2007

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Abstract

Background

Adult living donor liver transplantation (LDLT) has become a routine treatment option for patients waiting for liver transplantation. In European and North American countries, LDLT for adult recipients is mainly performed with right lobe grafts. Indications, when compared to deceased donor liver transplantation, are controversial.

Materials and methods

In our institution, patients suffering from hepatocellular carcinoma in cirrhosis, non-resectable hilar cholangiocarcinoma, viral hepatitis associated cirrhosis, as well as cholestatic liver and biliary disease are considered good candidates for LDLT.

Results

In this overview, donor evaluation, graft selection, and the donor operation with special regard to operative techniques and strategies are discussed. For visualization, a 5-min video sequence of the standard donor operation as performed in our institution is attached.

Conclusion

Given the ongoing shortage of donor organs, adult LDLT has become a routine treatment option for patients waiting for liver transplantation. The associated inevitable risk for the healthy donor, however, remains ethically controversial.
Appendix
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Literature
1.
go back to reference Cherqui D, Edmond JC, Pietrabissa A et al (1990) Segmental liver transplantation from living donors. Report of the technique and preliminary results in dogs. HPB Surg 2:189PubMedCrossRef Cherqui D, Edmond JC, Pietrabissa A et al (1990) Segmental liver transplantation from living donors. Report of the technique and preliminary results in dogs. HPB Surg 2:189PubMedCrossRef
2.
go back to reference Strong RW, Lynch SV, Ong TH et al (1990) Successful liver transplantation from a living donor to her son. N Eng J Med 322:1505–1507CrossRef Strong RW, Lynch SV, Ong TH et al (1990) Successful liver transplantation from a living donor to her son. N Eng J Med 322:1505–1507CrossRef
3.
go back to reference Hashikura Y, Makuuchi M, Kawasaki S et al (1994) Successful living-related partial liver transplantation to an adult patient. Lancet 343:1233–1234PubMedCrossRef Hashikura Y, Makuuchi M, Kawasaki S et al (1994) Successful living-related partial liver transplantation to an adult patient. Lancet 343:1233–1234PubMedCrossRef
4.
go back to reference Yamaoka Y, Washida M, Honda K et al (1994) Liver transplantation using a right lobe graft from a living related donor. Transplantation 57:1127–1130PubMedCrossRef Yamaoka Y, Washida M, Honda K et al (1994) Liver transplantation using a right lobe graft from a living related donor. Transplantation 57:1127–1130PubMedCrossRef
5.
go back to reference Lo CM, Fans ST, Liu CL et al (1997) Extending the limit on the size of adult recipient in living donor liver transplantation using extended right lobe graft. Transplantation 63:1524–1528PubMedCrossRef Lo CM, Fans ST, Liu CL et al (1997) Extending the limit on the size of adult recipient in living donor liver transplantation using extended right lobe graft. Transplantation 63:1524–1528PubMedCrossRef
7.
go back to reference Zieniewicz K, Skwarek A, Nyckowski P et al (2003) Comparison of the results of liver transplantation for elective versus urgent indications. Transplant Proc 35:2262–2264PubMedCrossRef Zieniewicz K, Skwarek A, Nyckowski P et al (2003) Comparison of the results of liver transplantation for elective versus urgent indications. Transplant Proc 35:2262–2264PubMedCrossRef
8.
go back to reference Uemoto S, Inomata Y, Sakurai T et al (2000) Living donor liver transplantation for fulminant hepatic failure. Transplantation 70:152–157PubMed Uemoto S, Inomata Y, Sakurai T et al (2000) Living donor liver transplantation for fulminant hepatic failure. Transplantation 70:152–157PubMed
9.
go back to reference Abt PL, Mange KC, Olthoff KM et al (2004) Allograft survival following adult-to-adult living donor liver transplantation. Am J Transplant 4:1302–1307PubMedCrossRef Abt PL, Mange KC, Olthoff KM et al (2004) Allograft survival following adult-to-adult living donor liver transplantation. Am J Transplant 4:1302–1307PubMedCrossRef
10.
go back to reference Liu CL, Fan ST, Lo CM et al (2002) Right-lobe live donor liver transplantation improves survival of patients with acute liver failure. Br J Surg 89:317–322PubMedCrossRef Liu CL, Fan ST, Lo CM et al (2002) Right-lobe live donor liver transplantation improves survival of patients with acute liver failure. Br J Surg 89:317–322PubMedCrossRef
11.
go back to reference Liu CL, Fan ST, Lo CM et al (2003) Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplantation 76:1174–1179PubMedCrossRef Liu CL, Fan ST, Lo CM et al (2003) Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure. Transplantation 76:1174–1179PubMedCrossRef
12.
go back to reference Garcia-Retortillo M, Forns X, Llovet JM et al (2004) Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation. Hepatology 40:699–707PubMedCrossRef Garcia-Retortillo M, Forns X, Llovet JM et al (2004) Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantation. Hepatology 40:699–707PubMedCrossRef
13.
go back to reference Russo MW, Shresta R (2004) Is severe recurrent hepatitis C more common after adult living donor liver transplantation? Hepatology 40:524–526PubMedCrossRef Russo MW, Shresta R (2004) Is severe recurrent hepatitis C more common after adult living donor liver transplantation? Hepatology 40:524–526PubMedCrossRef
14.
go back to reference Shiffman ML, Stravitz RT, Contos MJ et al (2004) Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation. Liver Transpl 10:1248–1255PubMedCrossRef Shiffman ML, Stravitz RT, Contos MJ et al (2004) Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation. Liver Transpl 10:1248–1255PubMedCrossRef
15.
go back to reference Schmeding M, Neumann UP, Puhl G et al (2007) Hepatitis-C recurrence and fibrosis progression are not increased after living donor liver transplantation—a single center study of 289 patients. Liver Transpl (in press) Schmeding M, Neumann UP, Puhl G et al (2007) Hepatitis-C recurrence and fibrosis progression are not increased after living donor liver transplantation—a single center study of 289 patients. Liver Transpl (in press)
16.
go back to reference Todo S, Furukawa H (2004) Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan. Ann Surg 240:451–461PubMedCrossRef Todo S, Furukawa H (2004) Living donor liver transplantation for adult patients with hepatocellular carcinoma: experience in Japan. Ann Surg 240:451–461PubMedCrossRef
17.
go back to reference Jonas S, Mittler J, Pascher A et al (2007) Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis. (in press) Jonas S, Mittler J, Pascher A et al (2007) Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis. (in press)
18.
go back to reference Gondolesi GE, Roayaie S, Munoz L, et al (2004) Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria. Ann Surg 239:142–149PubMedCrossRef Gondolesi GE, Roayaie S, Munoz L, et al (2004) Adult living donor liver transplantation for patients with hepatocellular carcinoma: extending UNOS priority criteria. Ann Surg 239:142–149PubMedCrossRef
19.
go back to reference Broelsch CE, Frilling A, Malago M (2005) Should we expand the criteria for liver transplantation for hepatocellular carcinoma—yes, of course! J Hepatol 43:569–573PubMedCrossRef Broelsch CE, Frilling A, Malago M (2005) Should we expand the criteria for liver transplantation for hepatocellular carcinoma—yes, of course! J Hepatol 43:569–573PubMedCrossRef
20.
go back to reference Jonas S, Mittler J, Pascher A et al (2005) Extended indications in living-donor liver transplantation: bile-duct cancer. Transplantation 80(Suppl 1):S101–S104PubMedCrossRef Jonas S, Mittler J, Pascher A et al (2005) Extended indications in living-donor liver transplantation: bile-duct cancer. Transplantation 80(Suppl 1):S101–S104PubMedCrossRef
21.
go back to reference Neuhaus P (2005) Live donor/split liver grafts for adult recipients: when should we use them? Liver Transpl 11(Suppl 1):S6–S9PubMedCrossRef Neuhaus P (2005) Live donor/split liver grafts for adult recipients: when should we use them? Liver Transpl 11(Suppl 1):S6–S9PubMedCrossRef
22.
go back to reference Pascher A, Sauer IM, Walter M et al (2002) Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation. Liver Transpl 8:829–837PubMedCrossRef Pascher A, Sauer IM, Walter M et al (2002) Donor evaluation, donor risks, donor outcome, and donor quality of life in adult-to-adult living donor liver transplantation. Liver Transpl 8:829–837PubMedCrossRef
23.
go back to reference Chisuwa H, Hashikura Y, Mita A et al (2003) Living liver donation: preoperative assessment, anatomic considerations and long-term outcome. Transplantation 75:1670–1676PubMedCrossRef Chisuwa H, Hashikura Y, Mita A et al (2003) Living liver donation: preoperative assessment, anatomic considerations and long-term outcome. Transplantation 75:1670–1676PubMedCrossRef
24.
go back to reference Valentin-Gamazo C, Malago M, Karliova M et al (2004) Experience after the evaluation of 700 potential donors for living donor liver transplantation in a single center. Liver Transpl 10(9):1087–1096PubMedCrossRef Valentin-Gamazo C, Malago M, Karliova M et al (2004) Experience after the evaluation of 700 potential donors for living donor liver transplantation in a single center. Liver Transpl 10(9):1087–1096PubMedCrossRef
25.
go back to reference Fan ST, Lo CM, Liu CL et al (2000) Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg 135:336–340PubMedCrossRef Fan ST, Lo CM, Liu CL et al (2000) Safety of donors in live donor liver transplantation using right lobe grafts. Arch Surg 135:336–340PubMedCrossRef
26.
go back to reference Kiuchi T, Tanaka K, Ito T et al (2003) Small-for-size graft in living donor liver transplantation: how far should we go? Liver Transpl 9(Suppl 1):S29–S35PubMedCrossRef Kiuchi T, Tanaka K, Ito T et al (2003) Small-for-size graft in living donor liver transplantation: how far should we go? Liver Transpl 9(Suppl 1):S29–S35PubMedCrossRef
27.
go back to reference Lemke AJ, Brinkmann MJ, Pascher A, Steinmueller T, Settmacher U, Neuhaus P, Felix R (2003) Accuracy of the CT-estimated weight of the right hepatic lobe prior to living related liver donation (LRLD) for predicting the intraoperatively measured weight of the graft. Rofo 175(9):1232–1238 (Sep)PubMed Lemke AJ, Brinkmann MJ, Pascher A, Steinmueller T, Settmacher U, Neuhaus P, Felix R (2003) Accuracy of the CT-estimated weight of the right hepatic lobe prior to living related liver donation (LRLD) for predicting the intraoperatively measured weight of the graft. Rofo 175(9):1232–1238 (Sep)PubMed
28.
go back to reference Lo CM, Fan ST, Liu CL et al (1999) Minimum graft size for successful living donor liver transplantation. Transplantation 68:1112–1116PubMedCrossRef Lo CM, Fan ST, Liu CL et al (1999) Minimum graft size for successful living donor liver transplantation. Transplantation 68:1112–1116PubMedCrossRef
29.
go back to reference Marcos A, Fisher RA, Ham JM et al (2000) Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation. Transplantation 69:1375–1379PubMedCrossRef Marcos A, Fisher RA, Ham JM et al (2000) Liver regeneration and function in donor and recipient after right lobe adult to adult living donor liver transplantation. Transplantation 69:1375–1379PubMedCrossRef
30.
go back to reference Varotti G, Gondolesi GE, Goldmann G et al (2004) Anatomic variations in right liver living donors. J Am Coll Surg 198:577–582PubMedCrossRef Varotti G, Gondolesi GE, Goldmann G et al (2004) Anatomic variations in right liver living donors. J Am Coll Surg 198:577–582PubMedCrossRef
31.
go back to reference Michels NA (1940) Newer anatomy of the liver and its variant blood supply and collateral circulation. Am J Surg 112:337–347CrossRef Michels NA (1940) Newer anatomy of the liver and its variant blood supply and collateral circulation. Am J Surg 112:337–347CrossRef
32.
go back to reference Hwang S, Lee SG, Lee YJ et al (2006) Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl 12:920–927PubMedCrossRef Hwang S, Lee SG, Lee YJ et al (2006) Lessons learned from 1,000 living donor liver transplantations in a single center: how to make living donations safe. Liver Transpl 12:920–927PubMedCrossRef
33.
go back to reference Fan ST, Lo CM, Liu CL et al (2003) Safety and necessity of including the middle hepatic vein in the right lobe graft in adult to adult live donor liver transplantation. Ann Surg 238:137–148PubMedCrossRef Fan ST, Lo CM, Liu CL et al (2003) Safety and necessity of including the middle hepatic vein in the right lobe graft in adult to adult live donor liver transplantation. Ann Surg 238:137–148PubMedCrossRef
34.
go back to reference Yamamoto H, Maetani Y, Kiuchi T et al (2003) Background and clinical impact of tissue congestion in right-lobe living donor liver grafts: a magnetic resonance imaging study. Transplantation 76:164–169PubMedCrossRef Yamamoto H, Maetani Y, Kiuchi T et al (2003) Background and clinical impact of tissue congestion in right-lobe living donor liver grafts: a magnetic resonance imaging study. Transplantation 76:164–169PubMedCrossRef
35.
go back to reference Kim BS, Kim TK, Kim JS et al (2004) Hepatic venous congestion after living donor liver transplantation with right lobe graft: two-phase CT-findings. Radiology 232:173PubMedCrossRef Kim BS, Kim TK, Kim JS et al (2004) Hepatic venous congestion after living donor liver transplantation with right lobe graft: two-phase CT-findings. Radiology 232:173PubMedCrossRef
36.
go back to reference Kaneko T, Sugimoto H, Hirota M et al (2005) Intrahepatic venous anastomosis formation of the right liver in living donor liver transplantation: evaluations by Doppler ultrasonography and pulse-inversion ultrasonography with Levovist. Surgery 138:21–27PubMedCrossRef Kaneko T, Sugimoto H, Hirota M et al (2005) Intrahepatic venous anastomosis formation of the right liver in living donor liver transplantation: evaluations by Doppler ultrasonography and pulse-inversion ultrasonography with Levovist. Surgery 138:21–27PubMedCrossRef
37.
go back to reference Ito T, Kiuchi T, Yamamoto H et al (2004) Efficacy of anterior segment drainage reconstruction in right lobe liver grafts from living donors. Transplantation 77:865–868PubMedCrossRef Ito T, Kiuchi T, Yamamoto H et al (2004) Efficacy of anterior segment drainage reconstruction in right lobe liver grafts from living donors. Transplantation 77:865–868PubMedCrossRef
38.
go back to reference Akamatsu N, Sugawara Y, Kaneko J et al (2003) Effects of middle hepatic vein reconstruction on right liver graft regeneration. Transplantation 76:832–837PubMedCrossRef Akamatsu N, Sugawara Y, Kaneko J et al (2003) Effects of middle hepatic vein reconstruction on right liver graft regeneration. Transplantation 76:832–837PubMedCrossRef
39.
go back to reference Cattral MS, Molinari M, Vollmer CM Jr et al (2004) Living donor right hepatectomy with or without inclusion of middle hepatic vein: comparison of morbidity and outcome in 56 patients. Am J Transplant 4:751–757PubMedCrossRef Cattral MS, Molinari M, Vollmer CM Jr et al (2004) Living donor right hepatectomy with or without inclusion of middle hepatic vein: comparison of morbidity and outcome in 56 patients. Am J Transplant 4:751–757PubMedCrossRef
40.
go back to reference Scatton O, Belghiti J, Dondero F et al (2004) Harvesting the middle hepatic vein with a right hepatectomy does not increase the risk for the donor. Liver Transpl 10:71–76PubMedCrossRef Scatton O, Belghiti J, Dondero F et al (2004) Harvesting the middle hepatic vein with a right hepatectomy does not increase the risk for the donor. Liver Transpl 10:71–76PubMedCrossRef
41.
go back to reference Hata S, Sugawara Y, Kishi Y et al (2004) Volume regeneration after right liver donation. Liver Transpl 10:65–70PubMedCrossRef Hata S, Sugawara Y, Kishi Y et al (2004) Volume regeneration after right liver donation. Liver Transpl 10:65–70PubMedCrossRef
Metadata
Title
Adult living donor liver transplantation: living donation of the right liver lobe
Authors
J. Mittler
A. Pascher
S. Jonas
J. Pratschke
U. P. Neumann
J. M. Langrehr
P. Neuhaus
Publication date
01-11-2007
Publisher
Springer-Verlag
Published in
Langenbeck's Archives of Surgery / Issue 6/2007
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-007-0187-0

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