Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Current Urology Reports
Published in: Current Urology Reports 4/2024

06-02-2024

Adult Hypospadias Outcomes for the Pediatric Urologist

Authors: Tyler Gaines, Jay Simhan

Published in: Current Urology Reports | Issue 4/2024

Login to get access

Abstract

Purpose of Review

This review article will examine the current literature on hypospadias-related complications in adult patients.

Recent Findings

In this article, we will review the most recent studies evaluating hypospadias-related stricture disease, erectile function, fertility, and psychosexual outcomes in adult men with history of hypospadias repair in childhood.

Summary

Managing hypospadias-related complications in adult patients is challenging to reconstructive urologists due to the compounded complexity of innate tissue deficiency and history of prior surgical repairs. In this review, we explore overall functional outcomes of adults with history of hypospadias repair as well as repair strategies of hypospadias-related urethral stricture disease. We will review erectile function, fertility and psychosexual outcomes as well as potential complications, which often do not surface until late adolescence and adulthood. Although it is challenging to characterize and quantify hypospadias-related complications, further longitudinal study is needed to better care for this complex patient population.
Literature
1.
Mai CT, Isenburg J, Langlois PH, et al. Population-based birth defects data in the United States, 2008 to 2012: presentation of state-specific data and descriptive brief on variability of prevalence. Birth Defects Res A Clin Mol Teratol. 2015;103:972–93.CrossRefPubMedPubMedCentral
2.
Duckett JW. Hypospadias in Campbell's urology. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ, editors. Campbell's urology. 7th ed. WA Saunders Company; 1998. p. 2093.
3.
Khuri FJ, Hardy BE, Churchill BM. Urologic anomalies associated with hypospadias. Urol Clin N Am. 1981;8:565–71.CrossRef
4.
Kass E, Kogan SJ, Mainley C. Timing of the elective surgery on the genitalia of male children with particular reference to risks benefits, psychological effects of surgery and anaesthesia. Pediatrics. 1996;97:590–4.CrossRef
5.
6.
Pfistermuller KL, McArdle AJ, Cuckow PM. Meta-analysis of complication rates of the tubularized incised plate (TIP) repair. J Pediatr Urol. 2015;11:54.CrossRefPubMed
7.
Perlmutter AE, Morabito R, Tarry WF. Impact of patient age on distal hypospadias repair: a surgical perspective. Urology. 2006;68:648.CrossRefPubMed
8.
Snodgrass WT, Bush N, Cost N. Algorithm for comprehensive approach to hypospadias reoperation using 3 techniques. J Urol. 2009;182:2885–91.CrossRefPubMed
9.
Long CJ, Chu DI, Tenney RW, Morris AR, Weiss DA, Shukla AR, Srinivasan AK, Zderic SA, Kolon TF, Canning DA. Intermediate-term followup of proximal hypospadias repair reveals high complication rate. J Urol. 2017;197(3 Pt 2):852–8.CrossRefPubMed
10.
Stanasel I, Le HK, Bilgutay A, Roth DR, Gonzales ET Jr, Janzen N, Koh CJ, Gargollo P, Seth A. Complications following Staged Hypospadias Repair Using Transposed Preputial Skin Flaps. J Urol. 2015;194(2):512–6.CrossRefPubMedPubMedCentral
11.
12.
Spinoit A-F, Poelaert F, Groen L-A, Van Laecke E, Hoebeke P. Hypospadias repair at a tertiary care center: long-term followup is mandatory to determine the real complication rate. J Urol. 2013;189(6):2276–81.CrossRefPubMed
13.
Lumen N, Hoebeke P, Willemsen P, De Troyer B, Pieters R, Oosterlinck W. Etiology of urethral stricture disease in the 21st century. J Urol. 2009;182(3):983–7.CrossRefPubMed
14.
Palminteri E, Berdondini E, Verze P, et al. Contemporary urethral stricture characteristics in the developed world. Urology. 2013;81:191–6.CrossRefPubMed
15.
• Barbagli G, Perovic S, Djinovic R, Sansalone S, Lazzeri M. Retrospective descriptive analysis of 1,176 patients with failed hypospadias repair. J Urol. 2010;183(1):207–11. Retrospective chart analysis of adults with complications related to hypospadias repair.
16.
• Myers JB, McAninch JW, Erickson BA, Breyer BN. Treatment of adults with complications from previous hypospadias surgery. J Urol. 2012;188(2):459–63. Retrospective study evaluating surgical treatment outcomes of adults with history of hypospadias repair in childhood.
17.
Grosfeld J, O'Neill J, Coran A et al. Pediatric Surgery (Sixth Edition),Mosby,2006,Pages i-lxviii. ISBN 9780323028424.
18.
Kulkarni S, Barbagli G, Sansalone S, Lazzeri M. One-sided anterior urethroplasty: a new dorsal onlay graft technique. BJU Int. 2009;104(8):1150–5.CrossRefPubMed
19.
Hayes MC, Malone PS. The use of a dorsal buccal mucosal graft with urethral plate incision (Snodgrass) for hypospadias salvage. BJU Int. 1999;83(4):508–9.CrossRefPubMed
20.
Asopa HS, Garg M, Singhal GG, Singh L, Asopa J, Nischal A. Dorsal free graft urethroplasty for urethral stricture by ventral sagittal urethrotomy approach. Urology. 2001;58(5):657–9.CrossRefPubMed
21.
22.
Kozinn SI, Harty NJ, Zinman L, Buckley JC. Management of complex anterior urethral strictures with multistage buccal mucosa graft reconstruction. Urology. 2013;82(3):718–22.CrossRefPubMed
23.
24.
Andrich DE, Mundy AR. Climate – a potential cause of primary graft failure in buccal mucosal graft urethroplasty. J Urol. 2009;181(Suppl 4):15.CrossRef
25.
Joshi PM, Barbagli G, Batra V, et al. A novel composite two-stage urethroplasty for complex penile strictures: a multicenter experience. Indian J Urol. 2017;33(2):155–8.CrossRefPubMedPubMedCentral
26.
Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol. 2002;167(5):2066–9. PMID: 11956440.
27.
Castellan M, Gosalbez R, Devendra J, Bar-Yosef Y, Labbie A. Ventral corporal body grafting for correcting severe penile curvature associated with single or two-stage hypospadias repair.
28.
Barbagli G, De Angelis M, Romano G, Lazzeri M. Clinical outcome and quality of life assessment in patients treated with perineal urethrostomy for anterior urethral stricture disease. J Urol. 2009;182(2):548–57.CrossRefPubMed
29.
Elliott SP, Eisenberg ML, McAninch JW. First-stage urethroplasty: utility in the modern era. Urology. 2008;71:889–92.CrossRefPubMed
30.
Rynja SP, Wouters GA, Van Schaijk M, Kok ET, De Jong TP, De Kort LM. Long-term followup of hypospadias: functional and cosmetic results. J Urol. 2009;182(4):1736–43.CrossRefPubMed
31.
Vandendriessche S, Baeyens D, Van Hoecke E, Indekeu A, Hoebeke P. Body image and sexuality in adolescents after hypospadias surgery. J Pediatr Urol. 2010;6(1):54–9.CrossRefPubMed
32.
Chertin B, Natsheh A, Ben-Zion I, Prat D, Kocherov S, Farkas A, Shenfeld OZ. Objective and subjective sexual outcomes in adult patients after hypospadias repair performed in childhood. J Urol. 2013;190(4):1556–60.CrossRefPubMed
33.
• Husmann DA. Erectile dysfunction in patients undergoing multiple attempts at hypospadias repair: Etiologies and concerns. J Pediatr Urol. 2021;17(2):166.e1-166.e7. Retrospective study evaluating erectile dysfunction in men with history of ≥ three prior hypospadias repair attempts.
34.
Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, et al. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev. 2016;96(1):55–97.CrossRefPubMed
35.
36.
Asklund C, Jensen TK, Main KM, Sobotka T, Skakkebaek NE, Jørgensen N. Semen quality, reproductive hormones and fertility of men operated for hypospadias. Int J Androl. 2010;33(1):80–7.CrossRefPubMed
37.
38.
Olofsson K, Oldbring J, Becker M, Åberg M, Svensson H. Self-perception after hypospadias repair in young men’s perspective. Eur J Plast Surg. 2003;26:294–7.CrossRef
39.
Liu G, Yuan J, Feng J, Geng J, Zhang W, Zhou X, et al. Factors affecting the long-term results of hypospadias repairs. J Pediatr Surg. 2006;41:554–9.CrossRefPubMed
40.
• Skarin Nordenvall A, Chen Q, Norrby C, Lundholm C, Frisén L, Nordenström A, Almqvist C, Nordenskjöld A. Fertility in adult men born with hypospadias: a nationwide register-based cohort study on birthrates, the use of assisted reproductive technologies and infertility. Andrology. 2020;8(2):372–80. Population-based cohort study evaluating fertility and confounding familial factors in men born with hypospadias.
41.
Kanematsu A, Tanaka S, Hashimoto T, Nojima M, Yamamoto S. Analysis of the association between paternity and reoperation for urethral obstruction in adult hypospadias patients who underwent two-stage repair in childhood. BMC Urol. 2019;19(1):88.CrossRefPubMedPubMedCentral
42.
• Tack LJW, Springer A, Riedl S, Tonnhofer U, Weninger J, Hiess M, Van Hoecke E. Psychosexual outcome, sexual function, and long-term satisfaction of adolescent and young adult men after childhood hypospadias repair. J Sex Med. 2020;17(9):1665–1675. Cross-sectional assessment of psychosexual functioning in adolescent and young adult men after childhood hypospadias repair.
43.
Andersson M, Sjöström S, Wängqvist M, Örtqvist L, Nordenskjöld A, Holmdahl G. Psychosocial and sexual outcomes in adolescents following surgery for proximal hypospadias in childhood. J Urol. 2018;200(6):1362–70.CrossRefPubMed
44.
Metadata
Title
Adult Hypospadias Outcomes for the Pediatric Urologist
Authors
Tyler Gaines
Jay Simhan
Publication date
06-02-2024
Publisher
Springer US
Published in
Current Urology Reports / Issue 4/2024
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-024-01196-7