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Journal of Ophthalmic Inflammation and Infection

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Open Access 01-12-2016 | Letter to the Editor

Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy

Authors: Savitha Madhusudhan, Pearse A. Keane, Alastair K. Denniston

Published in: Journal of Ophthalmic Inflammation and Infection | Issue 1/2016

Abstract

A challenge in the management of ‘white dot syndromes’ is the lack of sensitive objective measures of disease activity. Retinal thickness maps from spectral domain optical coherence tomography (SD-OCT) inform treatment decisions in other retinal conditions such as age-related macular degeneration and diabetic maculopathy. In this report, we demonstrate their value in providing quantitative monitoring of a patient with punctate inner choroidopathy (PIC). Retinal thickness maps referenced against a baseline scan reliably detected focal areas of increased macular volume in active PIC lesions during symptomatic episodes, highlighting these as ‘hot spots’ that could be quantified, providing an objective basis for treatment decisions.

Watzke RC, Packer AJ, Folk JC, Benson WE, Burgess D, Ober RR (1984) Punctate inner choroidopathy. Am J Ophthalmol 98(5):572–584CrossRefPubMed

Gerstenblith AT, Thorne JE, Sobrin L, Do DV, Shah SM, Foster CS, Jabs DA, Nguyen QD (2007) Punctate inner choroidopathy: a survey analysis of 77 persons. Ophthalmology 114(6):1201–1204CrossRefPubMed

Zhang X, Zuo C, Li M, Chen H, Huang S, Wen F (2013) Spectral-domain optical coherence tomographic findings at each stage of punctate inner choroidopathy. Ophthalmology 120(12):2678–2683CrossRefPubMed

Zarranz-Ventura J, Sim DA, Keane PA, Patel PJ, Westcott MC, Lee RW, Tufail A, Pavesio CE (2014) Characterization of punctate inner choroidopathy using enhanced depth imaging optical coherence tomography. Ophthalmology 121(9):1790–1797CrossRefPubMed

Li M, Zhang X, Wen F (2015) The fundus autofluorescence spectrum of punctate inner choroidopathy. J Ophthalmol 2015:202097CrossRefPubMedPubMedCentral

Pak JW, Narkar A, Gangaputra S, Klein R, Klein B, Meuer S, Huang Y, Danis RP (2013) Effect of optical coherence tomography scan decentration on macular center subfield thickness measurements. Invest Ophthalmol Vis Sci 54(7):4512–4518CrossRefPubMedPubMedCentral

Amer R, Lois N (2011) Punctate inner choroidopathy. Surv Ophthalmol 56(1):36–53CrossRefPubMed

Neri P, Manoni M, Fortuna C, Lettieri M, Mariotti C, Giovannini A (2010) Association of systemic steroids and mycophenolate mofetil as rescue therapy for uveitic choroidal neovascularization unresponsive to the traditional immunosuppressants: interventional case series. Int Ophthalmol 30(5):583–590CrossRefPubMed

Onal S, Tugal-Tutkun I, Neri P, P Herbort C (2014) Optical coherence tomography imaging in uveitis. Int Ophthalmol 34(2):401–435CrossRefPubMed

Title: Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy
Authors: Savitha Madhusudhan
Pearse A. Keane
Alastair K. Denniston
Publication date: 01-12-2016
Publisher: Springer Berlin Heidelberg
Published in: Journal of Ophthalmic Inflammation and Infection / Issue 1/2016
Electronic ISSN: 1869-5760
DOI: https://doi.org/10.1186/s12348-016-0073-4

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Adjunctive use of systematic retinal thickness map analysis to monitor disease activity in punctate inner choroidopathy

Abstract

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Abstract

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