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BMC Pediatrics
Published in: BMC Pediatrics 1/2021

Open Access 01-12-2021 | Adenovirus | Research

Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China

Authors: Yajie Zhang, Lin Qiao, Jinxiu Yao, Nan Yu, Xiaoping Mu, Shengqi Huang, Bo Hu, Weixuan Li, Feng Qiu, Fangyin Zeng, Cong Chen, Yuqiu Zhou, Bashan Zhang, Tian Cai, Weijia Wang, Xianjin Wu, Yiwen Zhou, Guochang Wang, Bo Situ, Shuling Lan, Na Li, Xiu Li, Zihua Li, Xin Li, Congrong Wang, Chao Yang, Pingfeng Feng, Hongxia Wang, Sijing Zhu, Yufeng Xiong, Min Luo, Wenjuan Shen, Xiumei Hu, Lei Zheng

Published in: BMC Pediatrics | Issue 1/2021

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Abstract

Background

Acute respiratory infections (ARI) cause considerable morbidity and mortality worldwide, especially in children. Unfortunately, there are limited multi-center data on common viral respiratory infections in south China.

Methods

A total of 4403 nasal swabs were collected from children in 10 cities in Guangdong, China in 2019. Seven respiratory viruses, influenza A virus (IFA), influenza B virus (IFB), respiratory syncytial virus (RSV), adenoviruses (ADV) and parainfluenza virus types 1–3 (PIV1, PIV2 and PIV3), were detected by direct immunofluorescence antibody assay. The personal information and clinical characteristics were recorded and analyzed.

Results

The results showed that at least one virus was detected in 1099 (24.96 %) samples. The detection rates of RSV, IFA, ADV, PIV3, PIV1 and PIV2 were 7.13 % (314/4403), 5.31 % (234/4403), 4.02 % (177/4403), 3.04 % (134/4403), 1.70 % (75/4403) and 1.16 % (51/4403), respectively. The detection rate of RSV was highest in 0–6-month-old children at 18.18 % (106/583), while the detection rate of IFA was highest in 12–18-year-old children at 20.48 % (17/83). The total detection rates in winter and spring were 35.67 % (219/614) and 34.56 % (403/1166), higher than those in summer, 17.41 % (284/1631), and autumn, 19.46 % (193/992).

Conclusions

RSV and IFA were the main respiratory viruses in children. With increasing age the detection rate of RSV decreased in children, but the trends for the detection rates of IFA and IFB were the opposite. This study provided the viral etiology and epidemiology of pediatric patients with ARI in Guangdong, China.
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Metadata
Title
Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China
Authors
Yajie Zhang
Lin Qiao
Jinxiu Yao
Nan Yu
Xiaoping Mu
Shengqi Huang
Bo Hu
Weixuan Li
Feng Qiu
Fangyin Zeng
Cong Chen
Yuqiu Zhou
Bashan Zhang
Tian Cai
Weijia Wang
Xianjin Wu
Yiwen Zhou
Guochang Wang
Bo Situ
Shuling Lan
Na Li
Xiu Li
Zihua Li
Xin Li
Congrong Wang
Chao Yang
Pingfeng Feng
Hongxia Wang
Sijing Zhu
Yufeng Xiong
Min Luo
Wenjuan Shen
Xiumei Hu
Lei Zheng
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-021-02759-0

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