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European Archives of Psychiatry and Clinical Neuroscience

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01-08-2021 | Addiction | Original Paper

Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study

Authors: Patrick Bach, Ulrich Frischknecht, Iris Reinhard, Nina Bekier, Traute Demirakca, Gabriele Ende, Sabine Vollstädt-Klein, Falk Kiefer, Derik Hermann

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 5/2021

Abstract

Opioid-dependent patients frequently show deficits in multiple cognitive domains that might impact on their everyday life performance and interfere with therapeutic efforts. To date, the neurobiological underpinnings of those deficits remain to be determined. We investigated working memory performance and gray matter volume (GMV) differences in 17 patients on opioid maintenance treatment (OMT) and 17 healthy individuals using magnetic resonance imaging and voxel-based morphometry. In addition, we explored associations between substance intake, gray matter volume, and working memory task performance. Patients on OMT committed more errors during the working memory task than healthy individuals and showed smaller insula and putamen GMV. The duration of heroin use prior to OMT was associated with working memory performance and insula GMV in patients. Neither the substitution agent (methadone and buprenorphine) nor concurrent abuse of illegal substances during the 3 months prior to the experiment was significantly associated with GMV. Results indicate that impaired working memory performance and structural deficits in the insula of opioid-dependent patients are related to the duration of heroin use. This suggests that early inclusion into OMT or abstinence-oriented therapies that shorten the period of heroin abuse may limit the impairments to GMV and cognitive performance of opioid-dependent individuals.

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Title: Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study
Authors: Patrick Bach
Ulrich Frischknecht
Iris Reinhard
Nina Bekier
Traute Demirakca
Gabriele Ende
Sabine Vollstädt-Klein
Falk Kiefer
Derik Hermann
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keywords: Addiction
Buprenorphine
Opioids
Opioids
Addiction
Methadone
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 5/2021
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-019-01052-7

Keynote webinar | Spotlight on medication adherence

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Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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